[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658776":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":31,"studyPopulation":32,"armGroups":27,"interventions":33,"overallOfficials":37,"centralContacts":42,"locations":27,"responsibleParty":51,"collaborators":27,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":27,"enrollmentInfo":63,"targetDuration":27,"studyType":66,"phases":27,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":81,"whyStopped":27,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":27},{"fullName":5,"class":6},"VASCage GmbH","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"Prevalence and characterization of cardiovascular comorbidities","Assessment of the prevalence, type, and distribution of cardiovascular comorbidities in patients with COPD and severe asthma based on clinical, laboratory, and imaging findings obtained during routine care.","Baseline and 24 months",[14,18,21,24],{"measure":15,"description":16,"timeFrame":17},"Exacerbation Frequency","Association between cardiovascular comorbidities and frequency of respiratory exacerbations.","24 months",{"measure":19,"description":20,"timeFrame":17},"Symptom Burden","Association between cardiovascular comorbidities and respiratory symptom burden as documented in routine clinical assessments.",{"measure":22,"description":23,"timeFrame":12},"Pulmonary Function","Association between cardiovascular comorbidities and pulmonary function parameters.",{"measure":25,"description":26,"timeFrame":17},"Treatment Modifications","Assessment of changes in therapeutic management associated with the identification and characterization of cardiovascular comorbidities.",null,{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":29,"timePerspective":30,"maskingInfo":27},"COHORT","PROSPECTIVE","Cardiovascular comorbidities are among the major determinants of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD) and severe asthma. Despite guideline recommendations, systematic assessment and management of cardiovascular disease in these patient populations remain heterogeneous in routine clinical practice.\n\nThe primary objective of the COINCIDE study is to characterize the prevalence and spectrum of cardiovascular comorbidities in adult patients with COPD or severe asthma treated at a tertiary pulmonary outpatient clinic. Furthermore, the study aims to evaluate the relationship between cardiovascular comorbidities and clinical outcomes, including exacerbation frequency, symptom burden, pulmonary function, and treatment strategies.\n\nThis is a single-center, prospective, longitudinal observational cohort study conducted at the Department of Pulmonology, Department of Internal Medicine II, Medical University of Innsbruck, Austria. Clinical, functional, laboratory, and imaging findings obtained during routine care will be collected in a structured manner and analyzed longitudinally.\n\nParticipants will undergo study assessments at baseline and after approximately 24 months. The study is planned to enroll up to 350 adult patients and will be conducted over five years.","The study population consists of adult patients (≥18 years) with a diagnosis of COPD GOLD Group B or E or severe asthma according to current GOLD and GINA recommendations. Participants are recruited from the specialized pulmonary outpatient clinic of the Department of Internal Medicine II, Medical University of Innsbruck, and receive routine clinical care. Patients are followed prospectively to assess cardiovascular comorbidities and their impact on clinical outcomes.",[34],{"type":6,"name":35,"description":36,"armGroupLabels":27,"otherNames":27},"Routine Clinical Care","Participants receive routine medical care according to local standards of care. No study-specific intervention, treatment allocation, or diagnostic procedure is performed.",[38],{"name":39,"affiliation":40,"role":41},"Thomas Sonnweber","Medical University Innsbruck","PRINCIPAL_INVESTIGATOR",[43,47],{"name":39,"role":44,"phone":45,"phoneExt":27,"email":46},"CONTACT","+43 512 504 82586","thomas.sonnweber@i-med.ac.at",{"name":48,"role":44,"phone":49,"phoneExt":27,"email":50},"Tina Pancheri","+43 51255443513","tina.pancheri@vascage.at",{"type":52,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100658776","coincide-cardineurovascular-disease-and-obstructive-airway-disease-100658776",false,"NCT07856667","COINCIDE: Cardineurovascular dIsease and Obstructive Airway Disease","Cardineurovascular Disease and Obstructive Airway Disease (COINCIDE): A Prospective Longitudinal Observational Cohort Study of Cardiovascular Comorbidities in Patients With COPD and Severe Asthma","COINCIDE","Inclusion Criteria:\n\n* Male or female participants aged 18 years or older.\n* Diagnosis of COPD GOLD Group B or E according to current GOLD recommendations, or severe asthma according to current GINA recommendations.\n* Receiving care at the specialized pulmonary outpatient clinic of the Department of Internal Medicine II, Medical University of Innsbruck.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Age below 18 years.\n* Inability or unwillingness to participate in study procedures.\n* Inability or unwillingness to provide written informed consent.\n* Planned transfer of care preventing longitudinal follow-up.\n* Pregnancy.","ALL","18 Years",{"count":64,"type":65},350,"ESTIMATED","OBSERVATIONAL","Patients with chronic obstructive pulmonary disease (COPD) and severe asthma frequently present with cardiovascular comorbidities that contribute substantially to morbidity and mortality. Early identification and appropriate management of cardiovascular disease are increasingly recognized as important components of comprehensive care for patients with obstructive airway diseases.\n\nThe COINCIDE study is a prospective longitudinal observational cohort study conducted at the Department of Pulmonology, Medical University of Innsbruck. The study aims to systematically document cardiovascular comorbidities in patients with COPD and severe asthma and to evaluate their association with disease progression, therapeutic management, exacerbation rates, symptom burden, and pulmonary function over time.\n\nClinical, functional, laboratory, and imaging data obtained as part of routine clinical care will be collected prospectively during two study visits separated by approximately 24 months. Up to 350 adult participants will be enrolled and followed over a period of five years.",[69,70,71],"Chronic Obstructive Pulmonary Disease (COPD)","Severe Asthma","Cardiovascular Diseases",[73,74,70,75,76,77,78,79,80],"COPD","Chronic Obstructive Pulmonary Disease","Cardiovascular Comorbidity","Cardiovascular Disease","Pulmonology","Cohort Study","Longitudinal Study","Real World Data","NOT_YET_RECRUITING","2026-10-05",{"date":84,"type":85},"2026-10-09","ACTUAL",{"date":87,"type":65},"2026-10-15",{"date":89,"type":65},"2031-06-15",{"name":5,"class":6}]