[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652188":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":23,"locations":28,"responsibleParty":62,"collaborators":65,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":10,"studyType":89,"phases":10,"briefSummary":90,"conditions":91,"keywords":10,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"London School of Hygiene and Tropical Medicine","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Project 1",null,"This prospective, community-based cohort will enrol approximately 3,000 participants from 15 villages across three districts of Odisha, India: Keonjhar, Boudh and Malkangiri, with five villages selected from each district. Participants aged 12 months to 69 years will be followed for four years, with study visits every six months before and after the monsoon season. At each visit, participants will undergo clinical assessment and finger-prick blood collection for malaria testing by rapid diagnostic test (RDT), microscopy and PCR. Samples will also be used for haemoglobin measurement and for the collection of plasma and erythrocytes for molecular and serological analyses, to monitor malaria epidemiology and transmission dynamics.",{"label":13,"type":10,"description":14,"interventionNames":10},"Project 2","This nested prospective sub-cohort will enroll approximately 1,000 participants selected from the parent cohort across six villages, with two villages selected from each district. Participants will be recruited from three villages, one per district, beginning at the 12-month visit of the parent study in Year 2, and from the remaining three villages, one per district, in Year 3.\n\nParticipants will undergo more frequent longitudinal sampling to characterise malaria transmission and infection dynamics using sero-epidemiology and circulating host- and parasite-derived biomarkers. Finger-prick blood samples will be collected for rapid diagnostic testing (RDT), microscopy, PCR-based detection of Plasmodium infection, and bead-based assays measuring anti-Plasmodium antibodies and other infection biomarkers.\n\nConcurrent entomological assessments conducted as part of the parent cohort will provide context on vector dynamics in relation to observed infection patterns and transmission.",[16,20],{"name":17,"affiliation":18,"role":19},"Samuel Wassmer, PhD","London School of Hygiene & Tropical Medicine, London","PRINCIPAL_INVESTIGATOR",{"name":21,"affiliation":22,"role":19},"Sanjib Mohanty, MBBS MD","Community Welfare Society Hospital, Odisha, India",[24],{"name":17,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+44 7930357115","sam.wassmer@lshtm.ac.uk",[29,51],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"ICMR-National Institute of Health Research","RECRUITING","Bhubaneswar","Odisha","751023","India","IN",{"type":38,"coordinates":39},"Point",[40,41],85.83385,20.27241,{"lat":41,"lon":40},[44,48,50],{"name":45,"role":25,"phone":46,"phoneExt":10,"email":47},"Madhusmita Bal, PhD","+916742301322","bal.madhusmita@icmr.gov.in",{"name":49,"role":19,"phone":10,"phoneExt":10,"email":10},"Sanghamitra Pati, MD MPH PhD",{"name":45,"role":19,"phone":10,"phoneExt":10,"email":10},{"facility":52,"status":31,"city":53,"state":33,"zip":54,"country":35,"countryCode":36,"cosmosGeoPoint":10,"geoPoint":10,"contacts":55},"Community Welfare Society Hospital (CWSH)","Raurkela","769042",[56,60,61],{"name":57,"role":25,"phone":58,"phoneExt":10,"email":59},"Praveen Kishore Sahu, PhD","+91 8895501174","drpraveenksahu@cwshospital.org",{"name":21,"role":19,"phone":10,"phoneExt":10,"email":10},{"name":57,"role":19,"phone":10,"phoneExt":10,"email":10},{"type":19,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Sam Wassmer","Professor of Malaria Pathogenesis",[66,69,72],{"name":67,"class":68},"National Institute of Allergy and Infectious Diseases (NIAID)","NIH",{"name":70,"class":71},"Community Welfare Society Hospital (CWSH), Rourkela, Odisha, India","UNKNOWN",{"name":73,"class":71},"ICMR-National Institute of Health Research, Bhubaneswar, Odisha, India","100652188","community-based-cohort-study-of-hidden-malaria-infections-diagnostic-gaps--mosquito-vector-dynamics-in-odisha-india-100652188",false,"NCT07770048","Community-Based Cohort Study of Hidden Malaria Infections, Diagnostic Gaps, & Mosquito Vector Dynamics in Odisha, India","The Center for the Study of Complex Malaria in India (CSCMi 3.0): Hidden Plasmodium Infections: Reservoirs, Impact, and Biomarker Discovery","CSCMi3","Inclusion Criteria:\n\n* Individuals 12 months to 69 years, all social classes, and all types of health status will be enrolled\n\nExclusion Criteria:\n\n* Individuals unable or unwilling to provide informed consent (or parental consent\u002Fassent for minors) Individuals unable to comply with study procedures or follow-up visits according to investigator judgement",true,"ALL","12 Months","69 Years",{"count":87,"type":88},3000,"ESTIMATED","OBSERVATIONAL","The goal of this prospective cohort study is to understand the factors responsible for the persistence of malaria transmission in some areas despite intensive control efforts. The study will measure the prevalence and incidence of asymptomatic and sub-patent Plasmodium infections and examine the factors that contribute to persistent transmission among residents of malaria-endemic areas of Odisha, India.\n\nThe main questions the study aims to answer are: Do asymptomatic and sub-patent Plasmodium infections contribute to persistent malaria transmission in endemic areas of Odisha? What is the frequency of false-negative results and incorrect species identification when microscopy and rapid diagnostic tests (RDTs) are compared with PCR? How is malaria epidemiology changing over time across areas with different transmission patterns, including shifts in Plasmodium species? What is the prevalence of asymptomatic gametocyte carriers, and how might they contribute to ongoing transmission? What are the characteristics and distribution of mosquito vectors in and around households, and how do they relate to transmission patterns? Can novel host- and parasite-derived biomarkers improve the detection of malaria infections, including asymptomatic cases?\n\nParticipants will provide blood samples for malaria testing by microscopy, RDT and PCR. A subset will provide additional samples for biomarker analysis as part of a nested sub-study. Participants will be followed over time to measure malaria infection prevalence, incidence and changes in transmission patterns. They will also take part in household-level assessments, including surveys and mosquito vector monitoring around their homes.",[92],"Malaria, Asymptomatic Parasitaemia","2026-08-10",{"date":95,"type":96},"2026-08-18","ACTUAL",{"date":98,"type":96},"2025-05-02",{"date":100,"type":88},"2029-05-31",{"name":5,"class":6},2]