[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655099":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":11,"studyPopulation":11,"armGroups":30,"interventions":41,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":51,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":11,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":11,"overallStatus":74,"whyStopped":11,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":11},{"fullName":5,"class":6},"Sohag University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"the occurrence of PONV during the initial 24 hours",null,"24 hours",[14,16,18],{"measure":15,"description":11,"timeFrame":12},"total opioid consumption over 24 hour (expressed as morphine milligram equivalents.",{"measure":17,"description":11,"timeFrame":12},"pain intensity scores (numerical rating scale NRS 0-10)",{"measure":19,"description":11,"timeFrame":12},"recovery quality (QoR-15 score)",{"allocation":21,"interventionModel":22,"interventionModelDescription":11,"primaryPurpose":23,"observationalModel":11,"timePerspective":11,"maskingInfo":24},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":25,"maskingDescription":11,"whoMasked":26},"TRIPLE",[27,28,29],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR",[31,36],{"label":32,"type":33,"description":11,"interventionNames":34},"conventential opioid-based anaesthesia (OBA, n=60).","PLACEBO_COMPARATOR",[35],"Drug: conventential opioid-based anaesthesia (OBA,",{"label":37,"type":38,"description":11,"interventionNames":39},"opioid free anesthesia( OFA , n=60)","EXPERIMENTAL",[40],"Drug: Opioid Free Anaesthesia",[42,47],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":11},"DRUG","Opioid Free Anaesthesia","The OFA group protocol consists of a combination of intravenous lidocaine, ketamine, dexmedetomidine, and propofol TIVA.",[37],{"type":43,"name":48,"description":49,"armGroupLabels":50,"otherNames":11},"conventential opioid-based anaesthesia (OBA,","The OBA group protocol consists of balanced anaesthesia with fentanyl plus sevoflurane.",[32],{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Islam Mokhtar Ahmed","Assistant professor of Anesthesia and Intensive Care","100655099","comparison-between-opioid-free-anaesthesia-versus-opioid-based-anesthesia-in-reduction-postoperative-nausea-and-vomiting-ponvafter-thoracoscopic-lung-resection-100655099",false,"NCT07806162","Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.","Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection. A Prospective Randomised Controlled Trial)","Inclusion Criteria:-\n\n* Eligible participants were adults (18-80 years).\n* Prepared for elective thoracoscopic lobectomy or segmentectomy for lung cancer under general anaesthesia\n\nExclusion Criteria:\n\n* Contraindication to any study drug (e.g., heart block, severe liver disease, allergy).\n* Chronic opioid use (\\>30 MME\u002Fday for \\>3 months).\n* Patients with renal impairment (e GFR \\\u003C30 mL\u002Fmin).\n* Pregnancy.\n* Inability to comprehend pain scales.","ALL","18 Years","80 Years",{"count":66,"type":67},120,"ESTIMATED","INTERVENTIONAL",[70],"NA","The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.",[73],"PONV","NOT_YET_RECRUITING","2026-09-01",{"date":77,"type":78},"2026-09-08","ACTUAL",{"date":80,"type":67},"2026-09",{"date":82,"type":67},"2026-11",{"name":5,"class":6}]