[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656367":3},{"organization":4,"outcomesModule":7,"designInfo":37,"detailedDescription":45,"studyPopulation":42,"armGroups":46,"interventions":62,"overallOfficials":70,"centralContacts":75,"locations":82,"responsibleParty":99,"collaborators":103,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":42,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":115,"minAge":116,"maxAge":42,"enrollmentInfo":117,"targetDuration":42,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":42,"overallStatus":85,"whyStopped":42,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"Universidad Complutense de Madrid","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Reduction in probing depth on the distal surface of the mandibular second molar","Periodontal probing depth (in millimeters) measured on the distal surface of the lower second molar using a calibrated periodontal probe (CP12). The reduction in probing depth will be compared among the three groups (autologous tooth graft, bovine xenograft, and blood clot control) to evaluate periodontal healing following extraction of the lower third molars.","Baseline (preoperative), 3 months, and 6 months post-extraction",[14,18,21,25],{"measure":15,"description":16,"timeFrame":17},"Postoperative swelling","Facial swelling measured as the linear distance between anatomical landmarks (tragus-commissure, tragus-gonion, and gonion-commissure) using a suture thread and caliper.","Preoperative, 48 hours, and 7 days post-extraction",{"measure":19,"description":20,"timeFrame":17},"Postoperative trismus","Maximum interincisal mouth opening measured in millimeters using a caliper.",{"measure":22,"description":23,"timeFrame":24},"Wound healing quality","linical evaluation of the surgical site according to Blum's criteria (good, acceptable, poor), based on mucosal color, bleeding, wound margins, and closure.","48 hours, and 7 days post-extraction",{"measure":26,"description":27,"timeFrame":28},"Patient-reported quality of life","Assessed using the Postoperative Symptom Severity (PoSSe) scale, covering pain, function, daily activities, and social interaction after surgery.","7 days post-extraction",[30,34],{"measure":31,"description":32,"timeFrame":33},"Surgical time","Minutes and seconds recorded intraoperatively","Intraoperatively",{"measure":35,"description":36,"timeFrame":33},"Surgical difficulty","Classified according to the modified Parant scale: Types I-IV",{"allocation":38,"interventionModel":39,"interventionModelDescription":40,"primaryPurpose":41,"observationalModel":42,"timePerspective":42,"maskingInfo":43},"RANDOMIZED","CROSSOVER","Each participant will receive two different interventions on opposite sides of the mandible in a randomized split-mouth design, comparing autologous tooth graft, bovine xenograft, and natural healing (blood clot).","TREATMENT",null,{"masking":44,"maskingDescription":42,"whoMasked":42},"NONE","This study investigates the healing of periodontal defects on the distal surface of the second lower molars after the surgical extraction of impacted third molars. Specifically, it compares the effectiveness of autologous tooth graft particles (derived from the extracted third molar) with bovine xenograft particles, using blood clot healing as a control.\n\nLower third molars are the most frequently impacted teeth, and their extraction can sometimes lead to or worsen periodontal defects on the adjacent second molar. Previous studies have shown positive outcomes using various bone regeneration materials; however, autologous tooth grafts have recently emerged as a biocompatible, osteoconductive, and osteoinductive alternative with promising results. Despite this, there are no clinical studies directly comparing autologous tooth grafts and bovine xenografts in this context-justifying the present research.\n\nA prospective, randomized split-mouth clinical trial with three arms will be conducted at the Complutense University of Madrid. Each patient will undergo bilateral lower third molar extractions under three conditions:\n\nGroup A (Test 1): socket filled with autologous tooth graft,\n\nGroup B (Test 2): socket filled with bovine xenograft,\n\nGroup C (Control): socket left to heal naturally with a blood clot.\n\nThe main objective is to evaluate the reduction in probing depth on the distal surface of the second molar six months post-extraction.\n\nSecondary outcomes include postoperative pain, inflammation, trismus, complications, wound healing, and patient-reported outcomes (PoSSe questionnaire).\n\nApproximately 30 patients will be included, with triple randomization (side of first extraction, use of graft, and graft type). Clinical and radiographic evaluations will be performed preoperatively, and follow-ups will occur at 48 hours, one week, three months, and six months.\n\nThe null hypothesis (H₀) states that there will be no periodontal differences between the two graft materials, while the alternative hypothesis (H₁) proposes superior periodontal outcomes with the autologous tooth graft compared to the bovine xenograft.",[47,53,58],{"label":48,"type":49,"description":50,"interventionNames":51},"Autologous Tooth Graft (Test 1)","EXPERIMENTAL","After surgical extraction of the impacted lower third molar, the socket will be filled with autologous tooth graft particles obtained from the extracted tooth using the Smart Dentin Grinder®. The graft particles (300-1200 µm) will be decontaminated, rinsed, and placed on the distal surface of the second molar. The graft will be covered with a resorbable hemostatic sponge (Roeko Gelatamp®) before suturing.",[52],"Biological: Autologous Tooth Graft",{"label":54,"type":55,"description":56,"interventionNames":57},"Bovine Xenograft (Test 2)","ACTIVE_COMPARATOR","After extraction of the impacted lower third molar, the socket will be filled with particulate bovine xenograft (InterOss®) hydrated in sterile saline. The material will be placed on the distal surface of the second molar and covered with a resorbable hemostatic sponge before suturing.",[52],{"label":59,"type":60,"description":61,"interventionNames":42},"Blood Clot (Control)","NO_INTERVENTION","Following extraction of the impacted lower third molar, the socket will be left to heal naturally through blood clot formation, without placement of any graft material or hemostatic sponge. Standard wound closure and postoperative care will be provided.",[63],{"type":64,"name":65,"description":66,"armGroupLabels":67,"otherNames":68},"BIOLOGICAL","Autologous Tooth Graft","Autologous tooth graft particles are prepared from the extracted third molar using the Smart Dentin Grinder®. The tooth is cleaned, dried, and ground to particles of 300-1200 µm, decontaminated with 0.5 M sodium hydroxide and 20% ethanol, rinsed with sterile saline, and placed on the distal surface of the second molar. The graft is covered with a resorbable hemostatic sponge (Roeko Gelatamp®) prior to wound closure.",[48,54],[69],"Smart Dentin Grinder®",[71],{"name":72,"affiliation":73,"role":74},"José María Martínez-González, MD,DMD,PhD,MDV","Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid","STUDY_DIRECTOR",[76],{"name":77,"role":78,"phone":79,"phoneExt":80,"email":81},"Miguel Ruiz Rincón, DDS","CONTACT","680276072","+34","migrui02@ucm.es",[83],{"facility":84,"status":85,"city":86,"state":86,"zip":87,"country":88,"countryCode":89,"cosmosGeoPoint":90,"geoPoint":95,"contacts":96},"Postgrado de especialización en cirugía bucal e implantología, Facultad de Odontología, Universidad Complutense de Madrid","RECRUITING","Madrid","28040","Spain","ES",{"type":91,"coordinates":92},"Point",[93,94],-3.70256,40.4165,{"lat":94,"lon":93},[97],{"name":77,"role":78,"phone":98,"phoneExt":80,"email":81},"680 27 60 72",{"type":100,"investigatorFullName":101,"investigatorTitle":102,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Miguel Ruiz Rincón","Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain.",[104],{"name":105,"class":106},"Bioner","UNKNOWN","100656367","comparison-of-autologous-tooth-and-bovine-xenograft-in-periodontal-healing-after-mandibular-third-molar-extraction-100656367",false,"NCT07824518","Comparison of Autologous Tooth and Bovine Xenograft in Periodontal Healing After Mandibular Third Molar Extraction","Evaluation of Changes in Probing Depth Following Surgical Extraction of Mandibular Third Molars Using Particulated Autologous Tooth vs. Particulated Bovine Xenograft vs. Blood Clot: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults (≥18 years old) of any sex, able to understand and follow study instructions.\n* Patients requiring bilateral surgical extraction of impacted lower third molars in horizontal or mesioangular position.\n* Presence of both lower second molars.\n* Classified as ASA I or ASA II (according to the American Society of Anesthesiologists).\n* Willingness to participate voluntarily and sign informed consent.\n\nExclusion Criteria:\n\n* Age under 18 years.\n* ASA physical status III, IV, V, or VI.\n* Pregnant or breastfeeding women.\n* Immunosuppressed patients.\n* Current treatment with NSAIDs, anticoagulants, or acetylsalicylic acid.\n* Previous or current treatment with bisphosphonates.\n* Presence of oral dysplasia or precancerous lesions.",true,"ALL","18 Years",{"count":118,"type":119},30,"ESTIMATED","INTERVENTIONAL",[122],"NA","This study investigates the healing of periodontal defects on the distal surface of the second lower molars after the surgical extraction of impacted third molars. Specifically, it compares the effectiveness of autologous tooth graft particles (derived from the extracted third molar) with bovine xenograft particles, using blood clot healing as a control.",[125,126],"Periodontal Defects After Third Molar Extraction","Periodontal Disease","2026-09-28",{"date":129,"type":130},"2026-10-01","ACTUAL",{"date":132,"type":130},"2025-09-01",{"date":134,"type":119},"2026-09-30",{"name":5,"class":6},1]