[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659483":3},{"organization":4,"outcomesModule":7,"designInfo":75,"detailedDescription":74,"studyPopulation":78,"armGroups":79,"interventions":74,"overallOfficials":89,"centralContacts":74,"locations":93,"responsibleParty":110,"collaborators":74,"id":113,"slug":114,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":115,"sex":121,"minAge":122,"maxAge":74,"enrollmentInfo":123,"targetDuration":126,"studyType":127,"phases":74,"briefSummary":128,"conditions":129,"keywords":132,"overallStatus":135,"whyStopped":74,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":74},[9],{"measure":10,"description":11,"timeFrame":12},"Partial pressure of oxygen (PaO₂) during one-lung ventilation","PaO₂ in mmHg obtained from arterial blood gas analysis of a radial artery sample, measured at 30 minutes after the initiation of one-lung ventilation, with FiO₂ recorded simultaneously","30-minutes after initiation of one-lung ventilation",[14,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,70],{"measure":15,"description":16,"timeFrame":17},"PaO₂\u002FFiO₂ ratio","Ratio of the partial pressure of arterial oxygen to the inspired oxygen fraction, calculated from arterial blood gas analysis.","0 and 30 minutes after initiation of one-lung ventilation, and immediately before resumption of two-lung ventilation, up to 240 minutes",{"measure":19,"description":20,"timeFrame":17},"Partial pressure of arterial carbon dioxide (PaCO₂)","PaCO₂ in mmHg obtained from arterial blood gas analysis.",{"measure":22,"description":23,"timeFrame":17},"Dynamic Compliance","Dynamic compliance obtained from ventilator readings",{"measure":25,"description":26,"timeFrame":17},"Pleteau Pressure","Pleteau pressure obtained from ventilator readings",{"measure":28,"description":29,"timeFrame":17},"Driving Pressure","Driving pressure obtained form ventilator settings",{"measure":31,"description":32,"timeFrame":17},"Mechanical Power","Mechanical power (J\u002Fmin) obtained and calculated form ventilator settings",{"measure":34,"description":35,"timeFrame":17},"Peak Inspiratory Pressure","Peak inspiratory pressure obtained form ventilator settings",{"measure":37,"description":38,"timeFrame":17},"Mean Airway Pressure","Mean airway pressure obtained and calculated form ventilator readings",{"measure":40,"description":41,"timeFrame":17},"Systolic Arterial Pressure","Systolic arterial pressure (mmHg) measured by invasive arterial monitoring",{"measure":43,"description":44,"timeFrame":17},"Diastolic Arterial Pressure","Diastolic arterial pressure (mmHg) measured by invasive arterial monitoring",{"measure":46,"description":47,"timeFrame":17},"Heart Rate","Heart rate (beats per minute) measured by continuous electrocardiographic monitoring",{"measure":49,"description":50,"timeFrame":17},"Mean Arterial Pressure","Mean arterial pressure (mmHg) measured by invasive arterial monitoring",{"measure":52,"description":53,"timeFrame":17},"Peripheral Oxygen Saturation","Peripheral oxygen saturation (SpO₂, %), measured by pulse oximetry",{"measure":55,"description":56,"timeFrame":17},"pH","pH obtained by arterial blood gas analysis",{"measure":58,"description":59,"timeFrame":17},"End-tidal CO₂","End-tidal CO₂ (mmHg), measured by capnography",{"measure":61,"description":62,"timeFrame":17},"Tidal Volume","Tidal volume (mL), obtained from ventilator readings",{"measure":64,"description":65,"timeFrame":17},"PEEP","PEEP (cmH₂O), obtained from ventilator readings",{"measure":67,"description":68,"timeFrame":69},"Postoperative pulmonary complications","Composite incidence of respiratory infection, respiratory failure, bronchospasm, atelectasis, pleural effusion, pneumothorax and aspiration pneumonia, assessed during the postoperative hospital stay.","From end of surgery through postoperative day 7 or hospital discharge, whichever occurs first",{"measure":71,"description":72,"timeFrame":73},"Lenght of stay and readmission","Duration of intensive care stay, ward stay, total hospital stay and hospital readmission after discharge.","From date of surgery to date of hospital discharge, up to 30 days",null,{"allocation":74,"interventionModel":74,"interventionModelDescription":74,"primaryPurpose":74,"observationalModel":76,"timePerspective":77,"maskingInfo":74},"COHORT","PROSPECTIVE","Patients aged 18 years and older, ASA physical status I-III, scheduled for elective lung resection by video-assisted thoracoscopic surgery (VATS) with planned one-lung ventilation under total intravenous anesthesia at a single tertiary center. Patients are assigned to one of three groups according to the ventilation mode selected by the attending anesthesiologist (FCV, VCV, or PCV); no randomization is performed.",[80,83,86],{"label":81,"type":74,"description":82,"interventionNames":74},"Flow-Controlled Ventilation","Patients ventilated with flow-controlled ventilation during one-lung ventilation, as selected by the attending anaesthesiologist",{"label":84,"type":74,"description":85,"interventionNames":74},"Volume-Controlled Ventilation","Patients ventilated with volume-controlled ventilation during one-lung ventilation, as selected by the attending anaesthesiologist",{"label":87,"type":74,"description":88,"interventionNames":74},"Pressure-Controlled Ventilation","Patients ventilated with pressure-controlled ventilation during one-lung ventilation, as selected by the attending anaesthesiologist",[90],{"name":91,"affiliation":5,"role":92},"Yenal ZORLU","PRINCIPAL_INVESTIGATOR",[94],{"facility":95,"status":74,"city":96,"state":74,"zip":97,"country":98,"countryCode":74,"cosmosGeoPoint":99,"geoPoint":104,"contacts":105},"Ankara Ataturk Sanatoryum Education and Research Hospital","Ankara","06290","Turkey (Türkiye)",{"type":100,"coordinates":101},"Point",[102,103],32.85427,39.91987,{"lat":103,"lon":102},[106],{"name":91,"role":107,"phone":108,"phoneExt":74,"email":109},"CONTACT","+90-506-809-14-71","yenalzorlu@icloud.com",{"type":92,"investigatorFullName":111,"investigatorTitle":112,"investigatorAffiliation":5,"oldNameTitle":74,"oldOrganization":74},"Yenal Zorlu","Resident Physician in Anesthesiology","100659483","comparison-of-different-ventilation-modes-in-video-assisted-thoracoscopic-lung-resection-100659483",false,"NCT07866170","Comparison of Different Ventilation Modes in Video-Assisted Thoracoscopic Lung Resection","Comparison of Flow-Controlled, Volume-Controlled, and Pressure-Controlled Ventilation During One-Lung Ventilation in Video-Assisted Thoracoscopic Lung Resection: A Prospective Observational Study","OLV-VENT","Inclusion Criteria:\n\n* -Age 18 years and older\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Scheduled for elective lung resection by video-assisted thoracoscopic surgery (VATS)\n* Planned one-lung ventilation\n* GOLD 2026 group 1 or group 2\n* Planned total intravenous anesthesia (TIVA)\n* Willing to participate and provides written informed consent\n\nExclusion Criteria:\n\n* ASA physical status IV or older\n* Emergency surgery\n* Previous neoadjuvant chemotheraphy or radiotherapy\n* GOLD 2026 group 3 or group 4\n* Pneumothorax, pleural effusion or interstitial lung disease\n* One-lung ventilation cannot be clinically maintained\n* Planned thoracotomy\n* Incomplete data\n* Refusal to participate","ALL","18 Years",{"count":124,"type":125},120,"ESTIMATED","1 Year","OBSERVATIONAL","One-lung ventilation (OLV) is required for video-assisted thoracoscopic surgery (VATS) lung resection, but it exposes the dependent lung to atelectasis, high driving pressures, and oxidative stress, and is associated with postoperative pulmonary complications. Volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) are the conventional modes used during OLV. Flow-controlled ventilation (FCV) is a newer mode that delivers a constant gas flow during both inspiration and expiration through a narrow-bore endotracheal tube, and has been proposed to improve gas distribution and reduce mechanical stress on the lung.\n\nThis prospective observational study evaluates oxygenation and respiratory mechanics in adult patients undergoing elective VATS lung resection under OLV. The ventilation mode used for each patient is determined by the attending anaesthesiologist as part of routine clinical care, independently of the study; investigators do not participate in any aspect of patient management and collect data through observation only. Patients are grouped according to the mode used in clinical practice (FCV, VCV, or PCV).\n\nThe primary outcome is arterial oxygenation (PaO₂) at 30 minutes of OLV. Secondary outcomes include dynamic lung compliance, driving pressure, mechanical power, and haemodynamic parameters recorded at predefined intervals. A total of 120 patients (ASA I-III, GOLD stage 1-2) are planned for enrolment.",[130,131],"One-lung Ventilation (OLV)","Video-assisted Thoracis Surgery (VATS)",[84,133,81,28,134,31],"Pressure-Controled Ventilation","Postoperative Complications","NOT_YET_RECRUITING","2026-10-07",{"date":138,"type":139},"2026-10-08","ACTUAL",{"date":141,"type":125},"2026-10-12",{"date":143,"type":125},"2027-09-03",{"name":5,"class":6},1]