[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650334":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":71,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":25,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Chulalongkorn University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sleeve gastrectomy with duodenojejunal bypass","EXPERIMENTAL","Sleeve gastrectomy with duodenojejunal bypass is a surgical technique in which the greater curvature of the stomach is resected and separated from the lesser curvature and antrum, reducing the gastric volume to approximately 80-150 mL (about 20% of the original capacity) using a 32-36 Fr bougie. Subsequently, the biliopancreatic limb is created by transecting the small intestine approximately 50-100 cm distal to the duodenojejunal (DJ) junction. A Roux (alimentary) limb measuring 150-200 cm in length is then constructed, followed by the creation of a duodenojejunostomy.",[13],"Procedure: Sleeve gastrectomy with duodenojejunal bypass",{"label":15,"type":16,"description":17,"interventionNames":18},"Roux-en-Y gastric bypass","ACTIVE_COMPARATOR","Roux-en-Y gastric bypass is a surgical technique in which the stomach is reduced to a small pouch with a volume of approximately 15-50 mL. The jejunum is then transected 40-50 cm distal to the duodenojejunal (DJ) junction and anastomosed to the gastric pouch to create the Roux (alimentary) limb, which is typically 75-150 cm in length. Finally, a jejunojejunostomy is performed to reconnect the small intestine.",[19],"Procedure: Roux-en-Y gastric bypass",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Novel bariatric procedure",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Standard bariatric procedure",[15],[30],{"name":31,"affiliation":32,"role":33},"Patchaya Boonchaya-anant, M.D.","King Chulalongkorn Memorial Hospital","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Primploy Greeviroj, M.D., M.Sc.","CONTACT","+66917142555","primploy.gre@chulahospital.org",[41],{"facility":32,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Pathum Wan","Bangkok","10330","Thailand","TH",{"type":49,"coordinates":50},"Point",[51,52],100.52329,13.73698,{"lat":52,"lon":51},[55,57,60,61,63,65,67,69],{"name":36,"role":37,"phone":56,"phoneExt":25,"email":39},"66917142555",{"name":31,"role":37,"phone":58,"phoneExt":25,"email":59},"66814416460","Patchaya.B@chula.ac.th",{"name":31,"role":33,"phone":25,"phoneExt":25,"email":25},{"name":36,"role":62,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":64,"role":62,"phone":25,"phoneExt":25,"email":25},"Natnicha Houngngam, M.Sc.",{"name":66,"role":62,"phone":25,"phoneExt":25,"email":25},"Pattharasai Kachornvitaya, M.D.",{"name":68,"role":62,"phone":25,"phoneExt":25,"email":25},"Suthep Udomsawaengsup, M.D.",{"name":70,"role":62,"phone":25,"phoneExt":25,"email":25},"Prangareeya Santisitthanon, B.Sc.",{"type":72,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[74],{"name":75,"class":76},"Ratchadapiseksompotch Research Fund","UNKNOWN","100650334","comparison-of-hormonal-response-to-a-mixed-meal-tolerance-test-after-laparoscopic-roux-en-y-gastric-bypass-versus-laparoscopic-sleeve-gastrectomy-with-duodenojejunal-bypass-in-patients-with-super-morbid-obesity-100650334",false,"NCT07747779","Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity","Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity: A Prospective Single-Center Non-Inferiority Randomized Clinical Trial","CU BYPASS-DJB","Inclusion Criteria:\n\n* Patients with an indication for bariatric surgery\n* BMI 50-60 kg\u002Fm2\n* Patients who are motivated to lose weight but have not achieved successful weight reduction despite optimal medical therapy and exercise under physician supervision\n\nExclusion Criteria:\n\n* Patients with diabetes mellitus\n* Patients with severe comorbid conditions that contraindicate surgery, such as advanced heart disease or chronic kidney failure\n* Patients with a history of previous bariatric surgery\n* Patients with gastroesophageal reflux disease refractory to medical therapy, large hiatal hernia, or endoscopic findings of reflux esophagitis grade C or D, or Barrett esophagus\n* Patients with psychiatric disorders that impair eating behavior control\n* Patients with a history of pancreatitis, pancreatic disease, or inflammatory bowel disease\n* Patients who have used steroids or GLP-1 receptor agonists within the past 2 months","ALL","18 Years","60 Years",{"count":89,"type":90},32,"ESTIMATED","INTERVENTIONAL",[93],"NA","Obesity is a major global health problem. Bariatric surgery is the most effective treatment, leading to substantial weight loss and improvement in obesity-related comorbidities. The most commonly performed procedures are Laparoscopic Roux-en-Y gastric bypass (LRYGB) and Laparoscopic sleeve gastrectomy (LSG). LRYGB is typically selected for patients with a BMI exceeding 50 kg\u002Fm2. Recently, LSG with duodenojejunal bypass (LSG-DJB) has been introduced. To date, no randomized controlled trial has compared LRYGB and LSG-DJB in patients with super morbid obesity, particularly regarding postoperative hormonal responses. This study aims to address this gap. If LSG-DJB results in a lower incidence of post-bariatric hypoglycemia than LRYGB, it would support its clinical benefit. Evaluation of GLP-1, GIP, glucagon, and insulin responses will clarify mechanisms underlying weight loss and postprandial glycemic changes.",[96,97,98],"Bariatric Surgery","Hormonal Response","Post Bariatric Hypoglycemia",[96,97,100],"Post bariatric hypoglycemia","2026-08-04",{"date":103,"type":104},"2026-08-06","ACTUAL",{"date":106,"type":104},"2024-08-08",{"date":108,"type":90},"2027-07-31",{"name":5,"class":6},1]