[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651685":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":25,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":84,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Hospital de Clinicas de Porto Alegre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Paravertebral Block Group","EXPERIMENTAL","Participants randomized to the continuous thoracic paravertebral block (BPV) group. At the end of surgery and before chest tube placement, a paravertebral catheter is inserted under direct thoracoscopic vision (without ultrasound) using a Tuohy needle. A bolus of ropivacaine 0.375% (15 mL, fractionated) is administered, followed by continuous infusion of bupivacaine 0.125% at 0.10 mL\u002Fkg\u002Fh. The target level is T5-T7 (or T5-T9). The catheter remains in place for at least 48 hours postoperatively.",[13],"Procedure: Continuous Thoracic Paravertebral Block",{"label":15,"type":16,"description":17,"interventionNames":18},"Epidural Block Group","ACTIVE_COMPARATOR","Participants randomized to the continuous thoracic epidural block (BPD) group. At the beginning of surgery, an epidural catheter is inserted at the thoracic level using the loss-of-resistance technique. A bolus of ropivacaine 0.375% (15 mL, fractionated) is administered, followed by continuous infusion of bupivacaine 0.125% at 0.10 mL\u002Fkg\u002Fh. The target level is T5-T7 (or T5-T9). The catheter remains in place for at least 48 hours postoperatively.",[19],"Procedure: Continuous Thoracic Epidural Block",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Continuous Thoracic Paravertebral Block",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Continuous Thoracic Epidural Block",[15],[30],{"name":31,"affiliation":32,"role":33},"Cristiano F Andrade, MD, PhD","Federal University of Rio Grande do Sul","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+55513359-6246","cfandrade@hcpa.edu.br",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Andre P. Schmidt, MD, MSc, PhD","+5551996412212","apschmidt@hcpa.edu.br",[44],{"facility":45,"status":25,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Hospital de Clínicas de Porto Alegre (HCPA)","Porto Alegre","Rio Grande Do Sul (RS)","90410-000","Brazil","BR",{"type":52,"coordinates":53},"Point",[54,55],-51.23019,-30.03283,{"lat":55,"lon":54},[58],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},{"type":60,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100651685","comparison-of-paravertebral-versus-epidural-block-for-post-thoracotomy-pain-control-100651685",false,"NCT07763249","Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control","Comparison Between Paravertebral Block and Epidural Block for the Management of Postoperative Pain in Patients Undergoing Thoracotomy and One-Lung Ventilation: A Prospective Non-inferiority Study.","Inclusion Criteria:\n\n* Patients aged 18 years or older;\n* Elective thoracic surgeries requiring open thoracotomy;\n* American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n* Pregnancy or lactation;\n* Urgent or emergency surgeries;\n* Contraindications to epidural catheter insertion or neuraxial anesthesia;\n* Infection at the proposed block site;\n* Patient refusal to undergo the study blocks;\n* Video-assisted thoracic surgeries;\n* Anticipated need for invasive mechanical ventilation in the postoperative period;\n* Chronic opioid use (daily use for more than 3 months of ≥10 mg oral morphine equivalent);\n* Severe vertebral deformities or previous thoracic spine surgery that prevent safe performance of the blocks;\n* Known allergy to local anesthetics, opioids, or study medications;\n* Body mass index \\> 35 kg\u002Fm²;\n* Advanced liver or kidney failure (Child-Pugh C or estimated glomerular filtration rate \\\u003C 50 mL\u002Fmin\u002F1.73 m²);\n* Severe cognitive impairment that prevents understanding of instructions or pain assessment.","ALL","18 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"NA","This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients undergoing elective open thoracotomy with one-lung ventilation. The primary outcome is the mean pain intensity at rest assessed by the Numeric Verbal Scale (NVS 0-10) during the first 48 hours after surgery. A total of 80 participants will be randomized 1:1 at Hospital de Clínicas de Porto Alegre, Brazil. The study aims to determine whether BPV provides non-inferior analgesia compared to BPD, with a potential advantage of less hemodynamic interference and better postoperative mobilization.",[78],"Postoperative Pain",[78,80,81,82,83],"Thoracotomy","Acute Pain","Thoracic Surgery","Regional Anesthesia","NOT_YET_RECRUITING","2026-08-10",{"date":87,"type":88},"2026-08-13","ACTUAL",{"date":90,"type":72},"2026-09-01",{"date":92,"type":72},"2028-07-31",{"name":5,"class":6},1]