[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649495":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":44,"collaborators":26,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":26,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":72,"whyStopped":26,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":26},{"fullName":5,"class":6},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SPSIP Block","EXPERIMENTAL","Participants will receive an ultrasound-guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB) using 30 mL of 0.25% bupivacaine before induction of general anesthesia. General anesthesia and postoperative analgesic management will be standardized for all participants.",[13],"Procedure: Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB)",{"label":15,"type":16,"description":17,"interventionNames":18},"SAP Block","ACTIVE_COMPARATOR","Participants will receive an ultrasound-guided Serratus Anterior Plane Block (SAPB) using 30 mL of 0.25% bupivacaine before induction of general anesthesia. General anesthesia and postoperative analgesic management will be standardized for all participants.",[19],"Procedure: Ultrasound-Guided Serratus Anterior Plane Block (SAPB)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB)","An ultrasound-guided serratus posterior superior intercostal plane block will be performed before induction of general anesthesia using 30 mL of 0.25% bupivacaine injected into the fascial plane between the serratus posterior superior muscle and the intercostal muscles.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Ultrasound-Guided Serratus Anterior Plane Block (SAPB)","Ultrasound-guided injection of 30 mL of 0.25% bupivacaine into the serratus anterior plane before induction of general anesthesia.",[15],[32],{"name":33,"affiliation":34,"role":35},"Dilek M Yamac","Sultan Abdülhamid Han education and research hospital","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Dilek M Yamac, MD","CONTACT","+905054959792","ddilekmetin@hotmail.com",{"name":33,"role":39,"phone":43,"phoneExt":26,"email":41},"05054959792",{"type":45,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100649495","comparison-of-postoperative-analgesic-efficacy-of-two-different-blocks-in-modified-radical-mastectomy-surgery-100649495",false,"NCT07737132","Comparison of Postoperative Analgesic Efficacy of Two Different Blocks in Modified Radical Mastectomy Surgery","Comparison of Postoperative Analgesic Efficacy of Superior Posterior Serratus Intercostal Plane Block (SPSIP) and Anterior Serratus Plane Block in Modified Radical Mastectomy Surgery","mastectomy","Inclusion Criteria:\n\n* Female patients aged 18 to 65 years.\n* Scheduled for elective modified radical mastectomy under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Body mass index (BMI) \\\u003C35 kg\u002Fm².\n* Normal coagulation profile (including INR and platelet count).\n* Normal liver and renal function tests.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics.\n* Coagulation disorders or bleeding diathesis.\n* Infection or inflammation at the planned block site.\n* ASA physical status IV or higher.\n* Chronic opioid use or chronic pain requiring long-term analgesic therapy.\n* Advanced hepatic or renal insufficiency.\n* Severe pulmonary disease.\n* Opioid use within 24 hours before surgery.\n* Cognitive impairment or inability to complete postoperative assessments.\n* Revision breast surgery.\n* Refusal to participate in the study.","FEMALE","18 Years","65 Years",{"count":58,"type":59},70,"ESTIMATED","INTERVENTIONAL",[62],"NA","Postoperative pain following modified radical mastectomy remains a significant clinical challenge and may delay recovery, impair patient comfort, and increase opioid consumption. Ultrasound-guided fascial plane blocks have become an important component of multimodal analgesia for breast surgery. The serratus anterior plane block (SAPB) is an established regional anesthesia technique that provides effective postoperative analgesia. The serratus posterior superior intercostal plane block (SPSIPB) is a recently described interfascial block with promising analgesic effects, but evidence comparing its efficacy with SAPB in breast surgery remains limited.\n\nThis prospective, randomized, double-blind, single-center clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided SPSIPB and SAPB in patients undergoing modified radical mastectomy under general anesthesia. Seventy female patients aged 18-65 years with American Society of Anesthesiologists (ASA) physical status I-III will be randomly assigned to receive either SPSIPB or SAPB before surgery. The primary outcome is postoperative pain intensity assessed using the Visual Analog Scale (VAS). Secondary outcomes include intraoperative remifentanil consumption, cumulative tramadol consumption during the first 24 postoperative hours, postoperative nausea and vomiting (PONV), quality of recovery assessed with the QoR-40 questionnaire, rescue analgesic requirements, and block-related complications. The findings of this study are expected to provide evidence regarding the comparative effectiveness and safety of these two interfascial plane blocks for postoperative analgesia in breast cancer surgery.",[65,66],"Breast Cancer","Postoperative Pain",[68,66,69,70,71],"Modified Radical Mastectomy","Ultrasound-Guided Nerve Block","Serratus Anterior Plane Block","Serratus Posterior Superior Intercostal Plane Block","NOT_YET_RECRUITING","2026-07-27",{"date":75,"type":76},"2026-07-30","ACTUAL",{"date":78,"type":59},"2026-08-01",{"date":80,"type":59},"2027-03-01",{"name":5,"class":6}]