[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650047":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":51,"locations":57,"responsibleParty":75,"collaborators":33,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":33,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":33,"enrollmentInfo":88,"targetDuration":33,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":60,"whyStopped":33,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Final International University","OTHER",[8,16,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Postoperative Treatment (Control)","ACTIVE_COMPARATOR","Participants receive standard postoperative treatment following impacted mandibular third molar surgery, including amoxicillin\u002Fclavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash. No platelet-rich fibrin (PRF) or corticosteroid is administered.",[13,14,15],"Drug: Amoxicillin\u002FClavulanic Acid","Drug: Paracetamol","Drug: Chlorhexidine",{"label":17,"type":18,"description":19,"interventionNames":20},"Platelet-Rich Fibrin (PRF)","EXPERIMENTAL","Participants receive platelet-rich fibrin (PRF) placed into the extraction socket in addition to standard postoperative treatment consisting of amoxicillin\u002Fclavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash following impacted mandibular third molar surgery.",[21,13,14,15],"Biological: Platelet-rich fibrin (PRF)",{"label":23,"type":18,"description":24,"interventionNames":25},"Platelet-Rich Fibrin Plus Corticosteroid","Participants receive platelet-rich fibrin (PRF) placement into the extraction socket followed by intramuscular corticosteroid administration, in addition to standard postoperative treatment consisting of amoxicillin\u002Fclavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash following impacted mandibular third molar surgery.",[21,26,13,14,15],"Drug: Dexamethasone",[28,34,39,43,47],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"BIOLOGICAL","Platelet-rich fibrin (PRF)","Autologous platelet-rich fibrin (PRF) prepared from the participant's venous blood by centrifugation at 3000 rpm for 10 minutes, and then placed into the extraction socket immediately after impacted mandibular third molar surgery.",[17,23],null,{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":33},"DRUG","Dexamethasone","Dexamethasone (8 mg\u002F2 mL) administered as a single intramuscular injection immediately after impacted mandibular third molar surgery in addition to platelet-rich fibrin (PRF), according to the study protocol.",[23],{"type":35,"name":40,"description":41,"armGroupLabels":42,"otherNames":33},"Amoxicillin\u002FClavulanic Acid","Amoxicillin\u002Fclavulanic acid administered postoperatively according to the study protocol.",[17,23,9],{"type":35,"name":44,"description":45,"armGroupLabels":46,"otherNames":33},"Paracetamol","Paracetamol 500 mg tablets administered postoperatively for pain control according to the study protocol.",[17,23,9],{"type":35,"name":48,"description":49,"armGroupLabels":50,"otherNames":33},"Chlorhexidine","Chlorhexidine mouthwash administered postoperatively according to the study protocol.",[17,23,9],[52],{"name":53,"role":54,"phone":55,"phoneExt":33,"email":56},"Meliz Kneebone, DDS","CONTACT","+905338425731","meliz-95@hotmail.com",[58],{"facility":59,"status":60,"city":61,"state":33,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Final International University Faculty of Dentistry","RECRUITING","Nicosia","2323","Cyprus","CY",{"type":66,"coordinates":67},"Point",[68,69],33.35397,35.17284,{"lat":69,"lon":68},[72,73],{"name":53,"role":54,"phone":55,"phoneExt":33,"email":56},{"name":53,"role":74,"phone":33,"phoneExt":33,"email":33},"PRINCIPAL_INVESTIGATOR",{"type":74,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Meliz Kneebone","Doctoral Researcher in Oral Surgery","100650047","comparison-of-prf-and-corticosteroids-in-impacted-third-molar-surgery-100650047",false,"NCT07742826","Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery","Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients with good general health\n* Patients with complete clinical and radiographic examination (panoramic radiograph\u002FCBCT if applicable)\n* Patients willing and able to attend all postoperative follow-up visits\n\nExclusion Criteria:\n\n* Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency).\n* Pregnant or breastfeeding women.\n* Patients with acute infection, abscess, or pericoronitis at the surgical site.\n* Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications.\n* Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates.\n* Patients with bleeding disorders.\n* Patients with previous radiotherapy to the head and neck region.\n* Patients unable or unwilling to comply with the study protocol or attend follow-up visits.",true,"ALL","18 Years",{"count":89,"type":90},60,"ESTIMATED","INTERVENTIONAL",[93],"NA","This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.",[96,97,98],"Impacted Mandibular Third Molar Extraction","Impacted Lower Third Molar","Impacted Wisdom Tooth",[100,101,102,103,104,105,106,107,108],"Third Molar Surgery","Impacted Third Molar","Platelet-Rich Fibrin","Corticosteroids","Postoperative Pain","Facial Swelling","Trismus","Oral Surgery","Postoperative Complications","2026-07-29",{"date":111,"type":112},"2026-08-03","ACTUAL",{"date":114,"type":112},"2024-09-03",{"date":116,"type":90},"2026-08",{"name":5,"class":6},1]