[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650078":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":22,"responsibleParty":103,"collaborators":10,"id":105,"slug":106,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":107,"sex":113,"minAge":114,"maxAge":10,"enrollmentInfo":115,"targetDuration":10,"studyType":118,"phases":10,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":25,"whyStopped":10,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Istituti Clinici Scientifici Maugeri SpA","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Heart failure with reduced ejection fraction (HFrEF) or mildly reduced ejection fraction (HFmrEF)",null,"Patients with HFrEF or EFmrEF will be assessed with 2D and 3D echocardiography to evaluate the agreement between 2D and 3D global longitudinal strain measurements",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Oronzo Catalano, MD","CONTACT","+39(0)382592608","oronzo.catalano@icsmaugeri.it",{"name":19,"role":15,"phone":20,"phoneExt":10,"email":21},"Miriam De Giorgi, DMS","+39(0)382592982","miriam.degiorgi@icsmaugeri.it",[23,45,60,74,89],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"ICS Maugeri - Istituto di Bari","RECRUITING","Bari","BA","70124","Italy","IT",{"type":32,"coordinates":33},"Point",[34,35],16.86982,41.12066,{"lat":35,"lon":34},[38,42],{"name":39,"role":15,"phone":40,"phoneExt":10,"email":41},"Caterina Rizzo, MD","+39(0)807814111","caterina.rizzo@icsmaugeri.it",{"name":43,"role":15,"phone":40,"phoneExt":10,"email":44},"Andrea Passantino, MD","andrea.passantino@icsmaugeri.it",{"facility":46,"status":25,"city":47,"state":48,"zip":49,"country":29,"countryCode":30,"cosmosGeoPoint":50,"geoPoint":54,"contacts":55},"ICS Maugeri - Istituto di Milano","Milan","MI","20138",{"type":32,"coordinates":51},[52,53],12.59836,42.78235,{"lat":53,"lon":52},[56],{"name":57,"role":15,"phone":58,"phoneExt":10,"email":59},"Edvige Palazzo Adriano, MD","+39(0)2507259","edvige.palazzoadriano@icsmaugeri.it",{"facility":61,"status":25,"city":62,"state":63,"zip":64,"country":29,"countryCode":30,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"ICS Maugeri - Istituto di Pavia","Pavia","PV","27100",{"type":32,"coordinates":66},[67,68],9.15917,45.19205,{"lat":68,"lon":67},[71,73],{"name":72,"role":15,"phone":20,"phoneExt":10,"email":17},"Oronzo Catalano, MD PI",{"name":19,"role":15,"phone":20,"phoneExt":10,"email":21},{"facility":75,"status":25,"city":76,"state":77,"zip":78,"country":29,"countryCode":30,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"ICS Maugeri Torino","Torino","TO","10124",{"type":32,"coordinates":80},[81,82],11.99138,44.88856,{"lat":82,"lon":81},[85],{"name":86,"role":15,"phone":87,"phoneExt":10,"email":88},"Franco Tarro Genta, MD","+39(0)118151611","franco.tarrogenta@icsmaugeri.it",{"facility":90,"status":25,"city":91,"state":10,"zip":92,"country":29,"countryCode":30,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"ICS Maugeri - Istituto di Veruno","Veruno","28013",{"type":32,"coordinates":94},[95,96],8.52863,45.68887,{"lat":96,"lon":95},[99],{"name":100,"role":15,"phone":101,"phoneExt":10,"email":102},"Fabiana Gambarin, MD","+39(0)322884711","fabiana.gambarin@icsmaugeri.it",{"type":104,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650078","comparison-of-three-dimensional-and-two-dimensional-left-ventricle-strain-with-speckle-tracking-echocardiography-in-heart-failure-with-reduced-and-mildly-reduced-ejection-fraction-100650078",false,"NCT07741305","Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction","Left Ventricular Myocardial Strain Assessed by Three-dimensional Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction. A Comparison With Two-dimensional Evaluation in a Prospective Study","3V2-STEM-HF","Inclusion Criteria:\n\n* Left ventricular ejection fraction (LVEF) ≤ 49%;\n* Echocardiographic image quality judged to be at least adequate according to a four-point visual image quality scale (good, adequate, poor, or inadequate)\n\nExclusion Criteria:\n\n* Inability to maintain the correct position for acquiring echocardiographic images;\n* Arrhythmias that make multi-beat acquisition impossible (if required), such as frequent extrasystoles (supraventricular or ventricular) and atrial fibrillation;\n* Failure to visualize more than 2 segments of the left ventricle (LV), or inability to assess more than 3 segments during 3D GLS analysis;\n* Failure to sign the informed consent form and inability of the participant to understand the objectives of the study","ALL","18 Years",{"count":116,"type":117},419,"ESTIMATED","OBSERVATIONAL","This study will compare two ultrasound techniques, 2D and 3D speckle-tracking echocardiography, for measuring how well the heart muscle contracts in patients with heart failure and reduced pumping function. While 2D global longitudinal strain (GLS) is widely used and has proven value in predicting outcomes, 3D GLS may provide a more complete assessment of heart function. Researchers will enroll 419 patients from seven cardiac rehabilitation hospitals in Italy and analyze heart ultrasound images using standardized equipment and software. The study will assess how closely 2D and 3D GLS measurements agree, identify factors that influence any differences, and determine whether 3D GLS better predicts the risk of death than 2D GLS.",[121],"Heart Failure",[123,124,125,126,127],"Myocardial strain","Speckle-Tracking Echocardiography","Heart failure with reduced ejection fraction (HFrEF)","Heart failure with mildly reduced ejection fraction (HFmrEF)","Three-Dimensional echocardiography","2026-08-18",{"date":130,"type":131},"2026-08-19","ACTUAL",{"date":133,"type":131},"2026-01-08",{"date":135,"type":117},"2027-12-31",{"name":5,"class":6},5]