[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652988":3},{"organization":4,"outcomesModule":7,"designInfo":40,"detailedDescription":49,"studyPopulation":39,"armGroups":50,"interventions":61,"overallOfficials":69,"centralContacts":73,"locations":78,"responsibleParty":94,"collaborators":39,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":99,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":39,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":81,"whyStopped":39,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Cairo University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":39},[9],{"measure":10,"description":11,"timeFrame":12},"Total fentanyl consumption.","Total fentanyl consumption in the first 24 hours (μg-microgram) postoperative.","24 hours.",[14,18,22,26,29,32,35],{"measure":15,"description":16,"timeFrame":17},"Time to first rescue analgesia.","Time elapsed from the end of surgery until the patient requires the first dose of rescue analgesia.","24 hours postoperatively.",{"measure":19,"description":20,"timeFrame":21},"Postoperative Pain scores.","pain assessment using Visual Analog Scale (VAS) score: pain level scored from 0 (no pain) to 10 (worst imaginable pain).","At Post Anesthesia Care Unit (PACU) and 2,4,6,12,18,24 hours Postoperatively.",{"measure":23,"description":24,"timeFrame":25},"Hemodynamic Parameter Heart rate","Heart rate","At PACU and 1,2,4,6,12,24 hours postoperatively.",{"measure":27,"description":28,"timeFrame":25},"Hemodynamic Parameter","mean arterial blood pressure",{"measure":30,"description":31,"timeFrame":25},"Hemodynamic Parameter oxygen saturation","oxygen saturation",{"measure":33,"description":34,"timeFrame":17},"Patient Satisfaction.","Degree of patients' satisfaction.",{"measure":36,"description":37,"timeFrame":38},"Incidence of postoperative complications.","Incidence of complications as hypotension, bradycardia, respiratory depression, pneumothorax and urine retention.","within 24 hours postoperatively.",null,{"allocation":41,"interventionModel":42,"interventionModelDescription":39,"primaryPurpose":43,"observationalModel":39,"timePerspective":39,"maskingInfo":44},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":45,"maskingDescription":39,"whoMasked":46},"DOUBLE",[47,48],"PARTICIPANT","OUTCOMES_ASSESSOR","This randomized controlled trial aims to compare the analgesic efficacy of ultrasound-guided transversus abdominis plane (TAP) block versus erector spinae plane block (ESPB) in adult patients undergoing laparoscopic renal surgeries. Forty adults (18-60 years, ASA I-II) will be randomly assigned to receive either TAP or ESPB after induction of general anesthesia.\n\nPreoperative assessment will include medical and surgical history, clinical examination, and routine laboratory investigations.\n\nIntraoperative management will follow standard monitoring with general anesthesia, and the block will be performed under ultrasound guidance using 0.25% bupivacaine, bilaterally. TAP block will be performed at the anterolateral abdominal wall, while ESPB will be performed at the T8-T9 level in lateral decubitus position. The anesthesiologist performing the block will not participate in postoperative data collection, and outcome assessors will be blinded.\n\nPostoperative pain management includes IV paracetamol every 8 hours and rescue fentanyl boluses (25 μg IV) if VAS ≥4, with a maximum total dose of 0.2-0.4 mg in 24 hours. Pain will be measured using the Visual Analogue Scale (VAS) at PACU, 2, 4, 6, 12, 18, and 24 hours. Secondary outcomes include time to first analgesic request, hemodynamic parameters, patient satisfaction, and incidence of adverse events such as PONV, hypotension, bradycardia, urinary retention, LAST, pneumothorax, or failed block.\n\nPrimary outcome: total fentanyl consumption in the first 24 hours postoperatively.\n\nSecondary outcomes: time to first rescue analgesia, VAS scores, hemodynamic stability, patient satisfaction, and complications. The study will be conducted at Cairo University Hospitals after ethical committee approval, with all patients providing written informed consent. Data will be analyzed using SPSS v26, with parametric and non-parametric tests, repeated-measures ANOVA for VAS over time, Kaplan-Meier analysis for time to rescue analgesia, and chi-square or Fisher's exact test for categorical outcomes.",[51,57],{"label":52,"type":53,"description":54,"interventionNames":55},"TAP Block group","EXPERIMENTAL","TAP block will be done under ultrasound-guidance with linear multi-frequency 6-13 MHz transducer probe and 21 G (0.514mm) needle inserted in-plane from medial to lateral, advanced through the fascial layers until the tip reaches the fascial plane between the internal oblique and the transversus abdominis muscle. After negative aspiration, 20 ml of 0.25% bupivacaine will be injected. Correct spread will be confirmed by separation of the fascial plane under ultrasound guidance. TAP block will be applied bilaterally.",[56],"Procedure: TAP Block",{"label":58,"type":53,"description":59,"interventionNames":60},"ESP Block group","a high-frequency linear ultrasound probe will be placed in a longitudinal parasagittal orientation over the transverse process at the T8-T9 level. A 21G needle will be advanced in-plane to reach the fascial plane deep to the erector spinae muscle and superficial to the transverse process. After negative aspiration, 20 ml of 0.25% bupivacaine (Sunnypivacaine®, Sunny pharmaceuticals, Egypt) will be injected incrementally to ensure correct spread of local anesthetic in the ESP plane.",[56],[62],{"type":63,"name":64,"description":65,"armGroupLabels":66,"otherNames":67},"PROCEDURE","TAP Block","a bilateral ultrasound guided TAP block performed by injecting 20 ml of 0.25% bupivacaine into the TAP space after negative aspiration.\n\na bilateral ultrasound guided ESP block performed by injecting 20 ml of 0.25% bupivacaine into the ESP space after negative aspiration.",[58,52],[68],"ESP Block",[70],{"name":71,"affiliation":5,"role":72},"Hala ElSabbagh, M.D.","PRINCIPAL_INVESTIGATOR",[74],{"name":71,"role":75,"phone":76,"phoneExt":39,"email":77},"CONTACT","01005207896","halaelsabbagh@gmail.com",[79],{"facility":80,"status":81,"city":82,"state":39,"zip":83,"country":84,"countryCode":85,"cosmosGeoPoint":86,"geoPoint":91,"contacts":92},"Kasr Al-Ainy hospital","RECRUITING","Cairo","11562","Egypt","EG",{"type":87,"coordinates":88},"Point",[89,90],31.24967,30.06263,{"lat":90,"lon":89},[93],{"name":71,"role":75,"phone":76,"phoneExt":39,"email":77},{"type":72,"investigatorFullName":95,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"Hala El Sabbagh,MD","lecturer of Anesthesiology","100652988","comparison-of-transversus-abdominis-plane-and-erector-spinae-plane-blocks-for-pain-control-after-renal-laparoscopy-100652988",false,"NCT07781930","Comparison of Transversus Abdominis Plane and Erector Spinae Plane Blocks for Pain Control After Renal Laparoscopy","Comparison of Ultrasound-guided Transversus Abdominis Plane Block (TAP) and Erector Spinae Plane Block (ESPB) for Postoperative Analgesia in Adult Laparoscopic Renal Surgeries: A Randomized Controlled Trial.","TAP-ESPB","Inclusion criteria:\n\n* Age from 18 to 40 years old.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I, II.\n* Scheduled for laparoscopic renal surgeries under general anesthesia\n\nExclusion criteria:\n\n* Parent's refusal.\n* Coagulation disorders.\n* History of allergy to local anesthetics.\n* Infection or redness at the injection site.\n* History of renal and\u002For hepatic insufficiency.\n* Preexisting cardiac dysfunction.","ALL","18 Years","40 Years",{"count":109,"type":110},60,"ESTIMATED","INTERVENTIONAL",[113],"NA","The goal of this study is to compare the analgesic efficacy of ultrasound-guided transversus abdominis plane (TAP) block versus erector spinae plane block (ESPB) in adult patients undergoing laparoscopic renal surgeries. Forty adults (18-60 years, ASA I-II) will be randomly assigned to receive either TAP or ESPB after induction of general anesthesia. Postoperative pain will be assessed using the Visual Analogue Scale (VAS) and total fentanyl consumption over 24 hours. Secondary outcomes include time to first analgesic request, hemodynamic parameters, patient satisfaction, and incidence of complications. The study will be conducted at Cairo University Hospitals following ethical approval, with all patients providing written informed consent.",[116],"Postoperative Pain, Acute",[64,68],"2026-08-21",{"date":120,"type":121},"2026-08-24","ACTUAL",{"date":123,"type":121},"2026-01-05",{"date":125,"type":110},"2026-08",{"name":5,"class":6},1]