[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646478":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":32,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":32,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":32,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":46,"whyStopped":32,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,14,17,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Passive exposure in car, 3 cartridges","EXPERIMENTAL","A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin",[13],"Other: Nitrous Oxide 99 %",{"label":15,"type":10,"description":11,"interventionNames":16},"Passive exposure in car, 4 cartridges",[13],{"label":18,"type":10,"description":19,"interventionNames":20},"Whipped cream, 100 g","A person ingests 100 g of whipped cream with nitrous oxide as propellant",[13],{"label":22,"type":23,"description":24,"interventionNames":25},"Environmental exposure","ACTIVE_COMPARATOR","concentrations of nitrous oxide are measured after exposure through work as a midwife in a delivery room",[26],"Other: Nitrous Oxide + Oxygen Gas",[28,33],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Nitrous Oxide 99 %","Passive exposure to Nitrous Oxide",[9,15,18],null,{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Nitrous Oxide + Oxygen Gas","Midwifes are exposed through work in a delivery room",[22],[38],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"Charlotte U Andersen, Associate Professor","CONTACT","+4560128430","cua@biomed.au.dk",[44],{"facility":45,"status":46,"city":47,"state":32,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Department of Forensic Medicine","RECRUITING","Aarhus","8200","Denmark","DK",{"type":52,"coordinates":53},"Point",[54,55],10.21076,56.15674,{"lat":55,"lon":54},[58],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},{"type":60,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100646478","concentrations-of-nitrous-oxide-in-blood-exhaled-air-and-urine-after-various-types-of-exposure-100646478",false,"NCT07690358","Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.","Undersøgelse af Lattergaskoncentrationer i Blod, udåndingsluft og Urin Ved Forskellige Eksponeringer","For arm 1, 2, and 3:\n\nInclusion Criteria:\n\n* Age 18-65 years\n* Able to understand Danish\n* Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives)\n* Written informed consent\n\nExclusion Criteria:\n\n* Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol\n* A psychiatric disorder requiring medical treatment, including severe depression\n* A diagnosis of epilepsy\n* Symptoms of peripheral neuropathy\n* Significant cardiac or pulmonary disease\n* Previous allergic or adverse reaction to N₂O\n* Diving within the past 2 days\n* Inability to refrain from diving for 2 days after the study\n* Occupational exposure to N₂O\n* Use of N₂O within the past 3 months\n* Treatment with methotrexate, benzodiazepines, opioids, or other centrally depressant drugs\n* Recent intraocular gas injection\n* Known impaired liver or kidney function\n* Pregnant or breastfeeding women (fertile women, defined as amenorrhea for less than 12 months, must have a negative hCG pregnancy test prior to receiving the study intervention)",true,"ALL","18 Years","65 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide:\n\ninhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide is used as a propellant, and exposure through work as a midwife in a delivery room.\n\nThe concentrations in blood and exhaled air are measured for up to 1 hour after exposure, and in urine for up to 2 hours after exposure. The concentrations in blood and urine are measued with gas chromatography and mass spectrometry, while the concentration in exhaled air is measured by a sensor using an NDIR sensor (Olythe, France).",[80],"Intoxication by Drug",[82,83,84,85],"Nitrous oxide","Forensic chemistry","driving under the influence","laughing gas","2026-07-07",{"date":88,"type":89},"2026-07-08","ACTUAL",{"date":91,"type":89},"2026-06-01",{"date":93,"type":74},"2026-12-31",{"name":5,"class":6},1]