[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611978":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":22,"studyPopulation":23,"armGroups":18,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":18,"responsibleParty":39,"collaborators":18,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":18,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":18,"studyType":56,"phases":18,"briefSummary":57,"conditions":58,"keywords":18,"overallStatus":61,"whyStopped":18,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":18},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"Frequency of CHDs among cholestatic infants","Assessment of prevalence of congenital heart diseases in infants below 2 years with cholestasis.","At initial clinical evaluation",[14],{"measure":15,"description":16,"timeFrame":17},"Types of CHDs identified in cholestatic infants","At baseline echocardiographic assessment","During hospital evaluation",null,{"allocation":18,"interventionModel":18,"interventionModelDescription":18,"primaryPurpose":18,"observationalModel":20,"timePerspective":21,"maskingInfo":18},"CASE_ONLY","CROSS_SECTIONAL","Congenital heart diseases (CHDs) are the most common structural malformations in childhood, affecting approximately 8-12 per 1,000 live births worldwide. Infants with systemic disorders such as neonatal and infantile cholestasis have a higher prevalence of CHDs due to overlapping prenatal insults, genetic syndromes, and metabolic disturbances. Cholestasis, defined as impaired bile flow with conjugated hyperbilirubinemia, may arise from biliary atresia, neonatal hepatitis, or metabolic and syndromic disorders such as Alagille syndrome. Several studies highlight a strong association between cholestasis and CHDs, and early recognition of this dual burden is essential to improve outcomes.","Infants with various causes of cholestatic disorders evaluated for congenital heart diseases and developmental outcomes.",[25],{"name":26,"affiliation":27,"role":28},"Dalia Mahran Mohammed, Prof.","Professor of Family Medicine","STUDY_CHAIR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"‪Shimaa Ahmed‬","CONTACT","01120432073","shimaa01120432073@gmail.com",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Dalia Mahran","01007120821","daliaym2001@yahoo.com",{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Shimaa Ahmed Mahros","Resident, Family Medicine Department","100611978","congenital-heart-diseases-and-developmental-assessment-in-cholestatic-infants-under-two-years-100611978",false,"NCT07247604","Congenital Heart Diseases and Developmental Assessment in Cholestatic Infants Under Two Years","Pattern of Congenital Heart Diseases and Developmental Evaluation in Children Below Two Years With Cholestasis at Assiut University Children's Hospital","Inclusion Criteria:\n\n* Children below 2 years presenting with cholestasis\n\nExclusion Criteria:\n\n* Prematurely born infants.","ALL","1 Month","2 Years",{"count":54,"type":55},106,"ESTIMATED","OBSERVATIONAL","Congenital heart diseases (CHDs) are common in infants with cholestasis due to shared prenatal and metabolic factors. This study aims to determine the frequency and types of CHDs and to assess physical and mental development in children below two years with cholestasis at Assiut University Children's Hospital.",[59,60],"Cholestasis","Congenital Heart Disease","NOT_YET_RECRUITING","2025-11-22",{"date":64,"type":65},"2025-11-25","ACTUAL",{"date":67,"type":55},"2025-12-11",{"date":69,"type":55},"2026-12-20",{"name":5,"class":6}]