[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625013":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":254,"collaborators":256,"id":260,"slug":261,"hasResults":262,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":23,"eligibilityCriteria":266,"healthyVolunteers":262,"sex":267,"minAge":26,"maxAge":268,"enrollmentInfo":269,"targetDuration":26,"studyType":272,"phases":273,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":288},{"fullName":5,"class":6},"NICHD Neonatal Research Network","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous Positive Airway Pressure","EXPERIMENTAL","CPAP will be provided via mask or binasal prongs to maintain a relatively uniform CPAP delivery system among infants in the treatment group. Bubble CPAP will be preferred over other modes of CPAP delivery whenever available.",[13],"Device: CPAP",{"label":15,"type":16,"description":17,"interventionNames":18},"Nasal Cannula","ACTIVE_COMPARATOR","HFNC at 4 L\u002Fmin will be used initially in the control group. Flow should be titrated down by 1 L\u002Fmin per day until ≤0.5 L\u002Fkg among infants in the nasal cannula group if not meeting pre-specified failure criteria to reduce the risk of inadvertent positive end-expiratory pressure (PEEP). Flow can also be increased (up to 6 L\u002Fmin maximum) if needed among infants on NC who meet the pre-specified failure criteria. Infants in the control group placed back on CPAP may use an interface at provider discretion.",[19],"Device: Nasal Cannula",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","CPAP","Prior to study entry, the CPAP interface (includes RAM cannula, Optiflow, large bore cannulas, mask, prongs) and mode (bubble, variable-flow, ventilator-derived) used is at the discretion of the provider and center. After study entry, CPAP will be provided via mask or binasal prongs to maintain a relatively uniform CPAP delivery system among infants in the treatment group. Bubble CPAP will be preferred over other modes of CPAP delivery whenever available.",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":28,"otherNames":26},[15],[30],{"name":31,"affiliation":32,"role":33},"Colm P. Travers, MD","University of Alabama at Birmingham","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":26,"email":38},"CONTACT","205-934-3100","cptravers@uabmc.edu",{"name":40,"role":36,"phone":41,"phoneExt":26,"email":42},"Abhik Das, PhD","301-230-4640","adas@rti.org",[44,61,75,88,102,116,130,144,158,172,186,199,213,227,240],{"facility":32,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-86.80249,33.52066,{"lat":55,"lon":54},[58,60],{"name":59,"role":36,"phone":26,"phoneExt":26,"email":26},"Waldemar A Carlo, MD",{"name":59,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":62,"status":45,"city":63,"state":64,"zip":65,"country":49,"countryCode":50,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Stanford University","Palo Alto","California","94304",{"type":52,"coordinates":67},[68,69],-122.14302,37.44188,{"lat":69,"lon":68},[72,74],{"name":73,"role":36,"phone":26,"phoneExt":26,"email":26},"Valerie Chock, MD",{"name":73,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":76,"status":45,"city":77,"state":64,"zip":78,"country":49,"countryCode":50,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Sharp Mary Birch Hospital for Women & Newborns","San Diego","92123",{"type":52,"coordinates":80},[81,82],-117.16472,32.71571,{"lat":82,"lon":81},[85,87],{"name":86,"role":36,"phone":26,"phoneExt":26,"email":26},"Anup Katheria, MD",{"name":86,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":89,"status":45,"city":90,"state":91,"zip":92,"country":49,"countryCode":50,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Emory University","Atlanta","Georgia","30303",{"type":52,"coordinates":94},[95,96],-84.38798,33.749,{"lat":96,"lon":95},[99,101],{"name":100,"role":36,"phone":26,"phoneExt":26,"email":26},"Ravi Patel, MD",{"name":100,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":103,"status":45,"city":104,"state":105,"zip":106,"country":49,"countryCode":50,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Northwestern Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"type":52,"coordinates":108},[109,110],-87.65005,41.85003,{"lat":110,"lon":109},[113,115],{"name":114,"role":36,"phone":26,"phoneExt":26,"email":26},"Aaron Hamvas, MD",{"name":114,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":117,"status":45,"city":118,"state":119,"zip":120,"country":49,"countryCode":50,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"University of Iowa","Iowa City","Iowa","52242",{"type":52,"coordinates":122},[123,124],-91.53017,41.66113,{"lat":124,"lon":123},[127,129],{"name":128,"role":36,"phone":26,"phoneExt":26,"email":26},"Tarah Colaizy, MD",{"name":128,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":131,"status":45,"city":132,"state":133,"zip":134,"country":49,"countryCode":50,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"University of Mississippi Medical Center - Children's of Mississippi","Jackson","Mississippi","39216",{"type":52,"coordinates":136},[137,138],-90.18481,32.29876,{"lat":138,"lon":137},[141,143],{"name":142,"role":36,"phone":26,"phoneExt":26,"email":26},"Abhay Bhatt, MD",{"name":142,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":145,"status":45,"city":146,"state":147,"zip":148,"country":49,"countryCode":50,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"University of New Mexico","Albuquerque","New 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Center","Cincinnati","Ohio","45267",{"type":52,"coordinates":178},[179,180],-84.51439,39.12711,{"lat":180,"lon":179},[183,185],{"name":184,"role":36,"phone":26,"phoneExt":26,"email":26},"Stephanie Merhar, MD MS",{"name":184,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":187,"status":45,"city":188,"state":175,"zip":189,"country":49,"countryCode":50,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"Case Western Reserve University, Rainbow Babies and Children's Hospital","Cleveland","44106",{"type":52,"coordinates":191},[192,193],-81.69541,41.4995,{"lat":193,"lon":192},[196,198],{"name":197,"role":36,"phone":26,"phoneExt":26,"email":26},"Anna M Hibbs, MD",{"name":197,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":200,"status":45,"city":201,"state":202,"zip":203,"country":49,"countryCode":50,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":52,"coordinates":205},[206,207],-75.16362,39.95238,{"lat":207,"lon":206},[210,212],{"name":211,"role":36,"phone":26,"phoneExt":26,"email":26},"Sara DeMauro, MD",{"name":211,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":214,"status":45,"city":215,"state":216,"zip":217,"country":49,"countryCode":50,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"University of Texas Southwestern Medical Center at Dallas","Dallas","Texas","75235",{"type":52,"coordinates":219},[220,221],-96.80667,32.78306,{"lat":221,"lon":220},[224,226],{"name":225,"role":36,"phone":26,"phoneExt":26,"email":26},"Myra Wyckoff, MD",{"name":225,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":228,"status":45,"city":229,"state":216,"zip":230,"country":49,"countryCode":50,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"University of Texas Health Science Center at Houston","Houston","77030",{"type":52,"coordinates":232},[233,234],-95.36327,29.76328,{"lat":234,"lon":233},[237,239],{"name":238,"role":36,"phone":26,"phoneExt":26,"email":26},"Matthew Rysavy, MD",{"name":238,"role":33,"phone":26,"phoneExt":26,"email":26},{"facility":241,"status":45,"city":242,"state":243,"zip":244,"country":49,"countryCode":50,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"University of Utah","Salt Lake City","Utah","84108",{"type":52,"coordinates":246},[247,248],-111.89105,40.76078,{"lat":248,"lon":247},[251,253],{"name":252,"role":36,"phone":26,"phoneExt":26,"email":26},"Robin Ohls, MD",{"name":252,"role":33,"phone":26,"phoneExt":26,"email":26},{"type":255,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[257],{"name":258,"class":259},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100625013","continued-pressure-for-alveolar-protection-cpap-trial-100625013",false,"NCT07417111","Continued Pressure for Alveolar Protection (CPAP Trial)","Continued Pressure for Alveolar Protection: A Randomized Controlled Trial (CPAP Trial)","Inclusion Criteria:\n\n* Gestational age \\\u003C29 weeks at birth\n* PMA \\\u003C32 weeks at study entry\n* On treatment with CPAP without a rate in FiO2 \\\u003C0.25 and PEEP of 4-5 cmH2O\n* Meet stability criteria:\n* If previously intubated must be extubated ≥ 72 hours\n* \\\u003C3 self-resolving apneas (≤ 20 s) and\u002For bradycardia (\\\u003C100 bpm) in any hour over previous 6 hours\n* No episodes of apnea or bradycardia requiring intervention (oxygen\u002Fstimulation\u002Fbag and mask) for 24 hours\n* Parents\u002Flegal guardians consent for enrollment\n\nExclusion Criteria:\n\n* Major malformation\n* Neuromuscular condition that affects respiration\n* Terminal illness\n* Decision to withhold or limit support\n* Too sick to participate in opinion of Attending physician\n* Clinical shock, sepsis\n* Planned surgery during study period","ALL","31 Weeks",{"count":270,"type":271},860,"ESTIMATED","INTERVENTIONAL",[274],"NA","The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.",[277],"Bronchopulmonary Dysplasia (BPD)",[9,23],"2026-07-13",{"date":281,"type":282},"2026-07-14","ACTUAL",{"date":284,"type":271},"2026-11-05",{"date":286,"type":271},"2029-01-30",{"name":5,"class":6},15]