[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645453":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":31,"responsibleParty":48,"collaborators":50,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":67,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Mỹ Đức Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"No Result (WGA Failure) NiPGT -A",null,"Embryos classified as having no NiPGT-A result due to unsuccessful whole genome amplification (WGA) of cell-free DNA obtained from the spent culture medium. These embryos are selected for transfer based solely on morphological assessment. Clinical outcomes after single frozen embryo transfer will be evaluated in this group.",{"label":13,"type":10,"description":14,"interventionNames":10},"Euploid NiPGT-A","Embryos classified as euploid based on NiPGT-A analysis of cell-free DNA obtained from the spent culture medium. Embryo selection for transfer is based only on morphological criteria according to routine clinical practice, and NiPGT-A results are blinded during treatment. Clinical outcomes will be compared with other NiPGT-A result groups.",{"label":16,"type":10,"description":17,"interventionNames":10},"Mosaic NiPGT-A","Embryos classified as mosaic according to NiPGT-A analysis of cell-free DNA from the spent culture medium. As in other groups, embryo transfer decisions are based solely on morphological evaluation, and NiPGT-A results are not used for clinical decision-making during the study.",{"label":19,"type":10,"description":20,"interventionNames":10},"Aneuploid NiPGT-A","Embryos classified as aneuploid according to NiPGT-A analysis of cell-free DNA obtained from the spent culture medium. Embryos included in this cohort are transferred based on morphological assessment without knowledge of NiPGT-A results. Clinical outcomes will be analyzed and compared with other groups.",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"HA TT NGUYEN, MSc","CONTACT","+84933091130","thaiha.nt@myduchospital.vn",{"name":28,"role":24,"phone":29,"phoneExt":10,"email":30},"TAM TM LUU, MSc","+84 357 426 024","tam.ltm@myduchospital.vn",[32],{"facility":33,"status":10,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"My Duc Hospital","Ho Chi Minh City","70000","Vietnam","VN",{"type":39,"coordinates":40},"Point",[41,42],106.62965,10.82302,{"lat":42,"lon":41},[45],{"name":46,"role":24,"phone":47,"phoneExt":10,"email":26},"Ha TT Nguyen, MSc","0933091130",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[51],{"name":52,"class":53},"My Duc Phu Nhuan Hospital HCMC, Vietnam","UNKNOWN","100645453","correlation-of-clinical-outcomes-after-transfer-of-good-quality-morphology-embryos-in-patients-with-a-favorable-prognosis-and-non-invasive-preimplantation-genetic-testing-for-aneuploidy-nipgt-a-results-100645453",false,"NCT07700602","Correlation Of Clinical Outcomes After Transfer Of Good-Quality Morphology Embryos In Patients With A Favorable Prognosis And Non-Invasive Preimplantation Genetic Testing For Aneuploidy (NiPGT-A) Results","Inclusion Criteria:\n\n* Women undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI).\n* Age younger than 35 years at the time of oocyte retrieval.\n* Good ovarian response, defined as having at least four good-quality embryos (Grade 1 or Grade 2) on Day 3 or later.\n* Undergoing the first or second IVF cycle.\n* Normal semen parameters of the male partner.\n* Willing to undergo non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) using spent embryo culture media.\n* Agree to vitrification of a single morphologically best-quality blastocyst and to undergo frozen single embryo transfer.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Presence of untreated uterine abnormalities, including uterine malformations or significant intrauterine pathology.\n* History of uterine surgery.\n* History of ovarian surgery.\n* Known metabolic disorders.\n* Use of donor oocytes.\n* In vitro maturation (IVM) cycles.\n* Participation in another clinical study during the study period.\n* Patients who do not undergo frozen single embryo transfer.",true,"FEMALE","18 Years","34 Years",{"count":65,"type":66},200,"ESTIMATED","24 Months","OBSERVATIONAL","Non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) is an emerging approach that analyzes embryonic cell-free DNA (cfDNA) released into the spent culture medium (SCM) to assess chromosomal status without performing trophectoderm biopsy. This technique has the potential to reduce procedural invasiveness and eliminate biopsy-related risks while providing additional information for embryo selection in assisted reproductive technology (ART). However, the clinical value of NiPGT-A remains uncertain because available evidence is limited and largely derived from observational studies, with few studies reporting live birth outcomes.\n\nThis prospective observational study aims to evaluate the correlation between NiPGT-A results and clinical outcomes after single blastocyst transfer in patients with a favorable prognosis undergoing IVF\u002FICSI treatment. In this study, embryos with good morphological quality will undergo non-invasive sampling of spent culture medium for cfDNA analysis. NiPGT-A results will be categorized into four groups: no result, euploid, mosaic, and aneuploid. The study will compare pregnancy and birth outcomes across these groups to determine the clinical utility of NiPGT-A in embryo selection strategies.",[71,72,73],"Infertility (IVF Patients)","Clinical Pregnancy After Single Embryo Transfer","Embryo Diagnosis and Selection",[75],"NiPGT, IVF, morphology, embryo selection","NOT_YET_RECRUITING","2026-07-13",{"date":79,"type":80},"2026-07-14","ACTUAL",{"date":82,"type":66},"2026-08-01",{"date":84,"type":66},"2029-12-31",{"name":5,"class":6},1]