[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649378":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":29,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":10,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":51,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"Hospital H+ Queretaro","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inhaled Sedation Cohort",null,"This cohort includes adult critically ill patients admitted to the intensive care unit at Hospital H+ Querétaro who required invasive mechanical ventilation for at least 24 hours and received inhaled sedation as their primary sedation strategy during ICU stay. In the study protocol, inhaled sedation is defined as the use of isoflurane administered through an anesthetic-conserving device. Patients in this cohort will be identified retrospectively through electronic medical record review and will be evaluated for total cost of care, duration of mechanical ventilation, ICU length of stay, adverse events, and relevant clinical covariates including age, sex, SOFA score, APACHE II score, and comorbidities. Patients with extracorporeal membrane oxygenation, severe traumatic brain injury, transfer to another unit, or less than 24 hours of mechanical ventilation will be excluded.",[13],"Drug: Isoflurane",{"label":15,"type":10,"description":16,"interventionNames":17},"Intravenous Propofol Cohort","This cohort includes adult critically ill patients admitted to the intensive care unit at Hospital H+ Querétaro who required invasive mechanical ventilation for at least 24 hours and received continuous intravenous propofol as their primary sedation strategy during ICU stay. These patients will also be identified retrospectively through review of electronic medical records and will serve as the comparison group for the cost-effectiveness analysis. Outcomes assessed in this cohort will include total cost of care, duration of mechanical ventilation, ICU length of stay, adverse events, and indirect costs, as well as baseline and clinical covariates such as age, sex, SOFA score, APACHE II score, and comorbidities. The same exclusion criteria will be applied to maintain comparability between cohorts.",[18],"Drug: Propofol (Astra-Zeneca)",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DRUG","Isoflurane","Isoflurane administered as inhaled sedation through an anesthetic-conserving device in mechanically ventilated critically ill adult patients in the intensive care unit.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Propofol (Astra-Zeneca)","Propofol administered as continuous intravenous sedation in mechanically ventilated critically ill adult patients in the intensive care unit.",[15],{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jose J Zaragoza, MD MSc","Principal Investigator","100649378","cost-effectiveness-of-inhaled-sedation-versus-intravenous-propofol-in-mechanically-ventilated-critically-ill-adults-100649378",false,"NCT07734350","Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults","Cost-effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Patients: a Retrospective ICU Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Admission to the intensive care unit at Hospital H+ Querétaro\n* Invasive mechanical ventilation for at least 24 hours\n* Receipt of inhaled sedation or continuous intravenous propofol sedation during ICU stay\n\nExclusion Criteria:\n\n* Extracorporeal membrane oxygenation\n* Severe traumatic brain injury\n* Transfer to another hospital unit\n* Less than 24 hours of mechanical ventilation","ALL","18 Years",{"count":43,"type":44},400,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit. The main questions it aims to answer are:\n\n* Does inhaled sedation reduce the total cost of care compared with intravenous propofol?\n* Does inhaled sedation reduce the duration of mechanical ventilation and ICU length of stay?\n* Are adverse events different between patients receiving inhaled sedation and those receiving intravenous propofol?\n\nResearchers will compare patients who received inhaled sedation with patients who received intravenous propofol to see if inhaled sedation improves clinical outcomes and reduces overall costs.\n\nParticipants will:\n\n* Be identified through review of electronic medical records\n* Be included if they are adults who received mechanical ventilation and were sedated with inhaled sedation or intravenous propofol\n* Contribute data on total costs of care, duration of mechanical ventilation, ICU length of stay, and adverse event",[48,49,50],"Critical Illness","Mechanical Ventilation","Respiratory Insufficiency",[52,53,54,55,56,57,58,59],"Inhaled sedation","Propofol","Mechanical ventilation","Critical illness","Intensive care unit","Cost-effectiveness","Critical care sedation","Adult ICU patients","NOT_YET_RECRUITING","2026-07-27",{"date":63,"type":64},"2026-07-29","ACTUAL",{"date":63,"type":44},{"date":67,"type":44},"2026-10-31",{"name":5,"class":6}]