[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616779":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":31,"collaborators":26,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":43,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":26,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":26},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Creatine group","EXPERIMENTAL","Patients in the creatine group will be instructed to take approximately 20g of creatine monohydrate daily for one week, followed by a maintenance phase of approximately 5g per day",[13],"Dietary Supplement: Creatine monohydrate",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo group","PLACEBO_COMPARATOR","Placebo group patients will be instructed to take a placebo following the same regimen as the creatine group.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Creatine monohydrate","Participants will receive creatine supplementation before surgery",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Participants in the placebo group will receive an identical placebo before surgery",[15],{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Susana Vacas, MD, PhD","Associate Professor","100616779","creatine-and-perioperative-brain-health-100616779",false,"NCT07310043","Creatine and Perioperative Brain Health","Creatine Intervention in Older Adults to Improve Perioperative Brain Health: a Randomized Controlled Trial (CREATE Trial)","CREATE","Inclusion Criteria:\n\n* Patients scheduled for elective surgery under general anesthesia\n\nExclusion Criteria:\n\n* History of creatine deficiency disorders\n* Renal or neurodegenerative disorders\n* History of stroke or significant head trauma, presence of intracranial mass lesions\n* Inability to give informed consent",true,"ALL","60 Years","85 Years",{"count":48,"type":49},120,"ESTIMATED","INTERVENTIONAL",[52],"NA","The overall goal of this study is to evaluate the feasibility of perioperative oral creatine supplementation and to explore its effects on cognitive function and physiological responses to surgery in older adults. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can alter thinking, memory, and attention patterns in some patients, we will assess whether creatine affects these changes in older adults undergoing surgery.",[55,56],"Neurocognitive Disorders","Postoperative Delirium",[58,59,60],"Perioperative Brain Health","Creatine","Perioperative Neurocognitive Disorders","NOT_YET_RECRUITING","2026-08-06",{"date":64,"type":65},"2026-08-10","ACTUAL",{"date":67,"type":49},"2026-09-01",{"date":69,"type":49},"2028-08-30",{"name":5,"class":6}]