[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651016":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":29,"collaborators":11,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":35,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":11,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":55,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":11},{"fullName":5,"class":6},"Spaulding Rehabilitation Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Creatine","EXPERIMENTAL",null,[13],"Dietary Supplement: Creatine monohydrate",{"label":15,"type":16,"description":11,"interventionNames":17},"Control","PLACEBO_COMPARATOR",[18],"Other: Microcrystalline Cellulose",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DIETARY_SUPPLEMENT","Creatine monohydrate","12 weeks of creating monohydrate supplementation at 5 gm, twice per day",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Microcrystalline Cellulose","Microcrystalline cellulose, which is an inert powder that is indistinguishable from creatine monohydrate in all sensory and procedural aspects, including appearance, taste, and solvability",[15],{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Jennifer C, Wu","Clinician Investigator","100651016","creatine-supplementation-in-pediatric-brain-injury-100651016",false,"NCT07756060","Creatine Supplementation in Pediatric Brain Injury","Creatine Supplementation in Pediatric Brain Injury: Brain Outcomes Optimization Through Supplementation Therapy","BOOST","Inclusion Criteria:\n\n* History of subacute moderate-to-severe brain injury resulting in a new functional impairment, as defined by: Glasgow Coma Scale score (GCS) \\\u003C 13 points\n* Subacute brain injury is defined to be \\\u003C 3 months since index injury\n\nExclusion Criteria:\n\n* Weight \\\u003C 25 kg\n* History pre-existing chronic kidney disease (CKD stage ≥ 2), prior kidney transplantation, previous dialysis dependence, or solitary kidney status\n* Premorbid (pre-brain injury) eGFR \\\u003C 60\n* Inability to obtain regular phlebotomy for any reason\n* Known inborn errors of mitochondrial function\n* Premorbid history of significant head trauma or brain injury requiring hospitalization\n* Pregnancy\n* Concurrent malignancy\n* Any other current, serious, chronic medical or psychiatric disease that in the PI's judgment may interfere with study participation or data integrity","ALL","8 Years","25 Years",{"count":45,"type":46},46,"ESTIMATED","INTERVENTIONAL",[49],"NA","A study examining the effects of creatine supplementation to improve recovery after brain injury in children and teenagers.",[52,53,54],"Brain Injury","Traumatic Brain Injury","Stroke",[56,57],"creatine","rehabilitation","NOT_YET_RECRUITING","2026-08-04",{"date":61,"type":62},"2026-08-10","ACTUAL",{"date":64,"type":46},"2026-10",{"date":66,"type":46},"2030-09",{"name":5,"class":6}]