[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658622":3},{"organization":4,"outcomesModule":7,"designInfo":37,"detailedDescription":43,"studyPopulation":36,"armGroups":44,"interventions":56,"overallOfficials":36,"centralContacts":64,"locations":70,"responsibleParty":86,"collaborators":36,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":36,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":36,"enrollmentInfo":99,"targetDuration":36,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":36,"overallStatus":73,"whyStopped":36,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"National Cancer Institute, Egypt","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":36},[9],{"measure":10,"description":11,"timeFrame":12},"Degree of pain","Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents \"no pain\" while 10 represents \"the worst pain imaginable\").","6 months after procedure",[14,17,20,23,26,29,33],{"measure":15,"description":16,"timeFrame":12},"Knee Injury and Osteoarthritis Outcome Score","Knee Injury and Osteoarthritis Outcome Score (KOOS) will measure\n\n* Pain\n* Symptoms\n* Activities of daily living\n* Sports\u002Frecreation\n* Quality of life",{"measure":18,"description":19,"timeFrame":12},"Western Ontario and McMaster Universities Osteoarthritis Index","Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index is a widely used, self-administered questionnaire that evaluates pain, stiffness, and physical function in patients with knee and hip osteoarthritis.",{"measure":21,"description":22,"timeFrame":12},"Oxford Knee Score","The Oxford Knee Score is a 12-item patient-reported questionnaire used to assess pain and physical function in the knee.\n\nScore Interpretation 0 to 19 (Severe): May indicate severe knee problems or advanced arthritis; surgical intervention like a knee replacement may be considered.\n\n20 to 29 (Moderate to Severe): Reflects considerable pain and functional limitations.\n\n30 to 39 (Mild to Moderate): Suggests mild-to-moderate joint issues with some activity limitations.\n\n40 to 48 (Satisfactory): Indicates normal or satisfactory joint function with minimal knee problems.",{"measure":24,"description":25,"timeFrame":12},"Patient Global Impression of Change (PGIC)","The traditional Patient Global Impression of Change (PGIC) uses a 7-point scale where patients select the statement that best describes their current state compared to how they felt before treatment:\n\n1. Very much improved (or Much better)\n2. Much improved\n3. Minimally improved\n4. No change (or The same)\n5. Minimally worse\n6. Much worse\n7. Very much worse (or Very much worse)",{"measure":27,"description":28,"timeFrame":12},"Measurement of quality of life","Quality of life will be assessed using EuroQol 5-Dimension 5-Level (EQ-5D-5L).",{"measure":30,"description":31,"timeFrame":32},"Total analgesic consumption","Total analgesic consumption will be recorded.","24 hours after procedure",{"measure":34,"description":35,"timeFrame":32},"Incidence of complication","Incidence of complication will be recorded.",null,{"allocation":38,"interventionModel":39,"interventionModelDescription":36,"primaryPurpose":40,"observationalModel":36,"timePerspective":36,"maskingInfo":41},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":42,"maskingDescription":36,"whoMasked":36},"NONE","Knee osteoarthritis (KOA) is a major cause of chronic pain and disability worldwide. Pain in knee osteoarthritis is multifactorial and does not always correlate with the degree of radiographic degeneration. In addition to structural joint changes, pain results from synovial inflammation, subchondral bone remodeling, periosteal irritation, ligamentous stress, and sensitization of peripheral and central nociceptive pathways.\n\nAmong the available interventional approaches, radiofrequency ablation (RFA) and cryoneurolysis have gained increasing attention because they interrupt pain transmission without affecting joint stability. Radiofrequency ablation (RFA) and cryoneurolysis are two emerging techniques that modulate pain transmission pathways. Bipolar radiofrequency ablation uses thermal energy delivered between two closely positioned electrodes to create a larger and more continuous lesion than conventional monopolar RFA.",[45,51],{"label":46,"type":47,"description":48,"interventionNames":49},"Cryoneurolysis group","EXPERIMENTAL","Patients will undergo ultrasound-guided cryoneurolysis",[50],"Procedure: Ultrasound-guided cryoneurolysis",{"label":52,"type":47,"description":53,"interventionNames":54},"Radiofrequency ablation group","Patients will undergo bipolar radiofrequency ablation",[55],"Procedure: Bipolar radiofrequency ablation",[57,61],{"type":58,"name":59,"description":48,"armGroupLabels":60,"otherNames":36},"PROCEDURE","Ultrasound-guided cryoneurolysis",[46],{"type":58,"name":62,"description":53,"armGroupLabels":63,"otherNames":36},"Bipolar radiofrequency ablation",[52],[65],{"name":66,"role":67,"phone":68,"phoneExt":36,"email":69},"Ahmed S Abdelgalil, MD","CONTACT","00201098426689","ahmed.salah@nci.cu.edu.eg",[71],{"facility":72,"status":73,"city":74,"state":36,"zip":75,"country":76,"countryCode":77,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"Cairo University","RECRUITING","Cairo","12613","Egypt","EG",{"type":79,"coordinates":80},"Point",[81,82],31.24967,30.06263,{"lat":82,"lon":81},[85],{"name":66,"role":67,"phone":68,"phoneExt":36,"email":69},{"type":87,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Ahmed Salah Ahmed Abd Elgalil","Associate Professor of Anaesthesia and Pain Medicine National Cancer, Cairo University.","100658622","cryoneurolysis-versus-bipolar-radiofrequency-ablation-of-genicular-nerves-for-pain-relief-in-symptomatic-knee-osteoarthritis-100658622",false,"NCT07855367","Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis","Ultrasound-Guided Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 40 years\n* Symptomatic knee osteoarthritis (OA) in bladder cancer patient \\[based on American College of Radiology (ACR) criteria\\]\n* Radiological OA (Kellgren-Lawrence grade III-IV)\n* Chronic knee pain ≥ 3-6 months\n* Numerical Rating Scale (NRS) ≥ 5 despite conservative treatment\n* Positive diagnostic genicular nerve block (\\>50% pain relief).\n\nExclusion Criteria:\n\n* Prior genicular nerve ablation\n* Coagulopathy\n* Local infection\n* Severe deformity\n* Neuropathic pain syndromes\n* Uncontrolled comorbidities","ALL","40 Years",{"count":100,"type":101},30,"ESTIMATED","INTERVENTIONAL",[104],"NA","This study aims to compare the reduction in knee pain between ultrasound-guided cryoneurolysis and bipolar radiofrequency ablation (RFA), as measured by the Numerical Rating Scale (NRS) at predefined follow-up intervals.",[107,108,109,110,111,112],"Cryoneurolysis","Bipolar Radiofrequency Ablation","Genicular Nerves","Pain Relief","Symptomatic","Knee Osteoarthritis","2026-09-28",{"date":115,"type":116},"2026-10-02","ACTUAL",{"date":118,"type":116},"2026-09-15",{"date":120,"type":101},"2027-03-15",{"name":5,"class":6},1]