[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100390472":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":41,"locations":51,"responsibleParty":71,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":27,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":54,"whyStopped":27,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Russian Society of Colorectal Surgeons","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"D2 lymph node dissection","ACTIVE_COMPARATOR","For tumours in splenic flexure and proximal and mid part of descending colon lymph nodes 232 and 231 will be removed.\n\nFor tumours in distal part of descending colon and proximal sigmoid lymph nodes 231, 232 and partially 241, 242 (considering variation of the feeding artery) will be removed.\n\nFor tumours in the mid part of sigmoid colon lymph nodes 241, 242 will be removed.\n\nFor tumours in the rectosigmoid junction 251, 252 groups of the lymph node will be removed.",[13,14,15],"Procedure: Left colon resection","Procedure: Sigmoid colon resection","Procedure: Distal sigmoid colon resection or anterior resection",{"label":17,"type":18,"description":19,"interventionNames":20},"D3 lymph node dissection","EXPERIMENTAL","For tumours in splenic flexure and proximal and mid part of descending colon lymph nodes 232, 231 and 253 will be removed.\n\nFor tumours in distal part of descending colon and proximal sigmoid lymph nodes 231, 232 and 253 and partially 241, 242 (considering variation of the feeding artery) will be removed.\n\nFor tumours in the mid part of sigmoid colon lymph nodes 241, 242 and 253 will be removed.\n\nFor tumours in the rectosigmoid junction 251, 252 and 253 groups of the lymph node will be removed.",[13,14,15],[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Left colon resection","This procedure is performed for tumours in splenic flexure and proximal and descending colon.\n\nLeft colic artery is divided at its origin. Sigmoid arteries and superior rectal arteries are preserved. Inferior mesenteric vein is divided at the lower border of the pancreas. The colon is divided about 10 cm proximal and distal to the tumour. Mesocolic fascia is preserved and the length of the \"vessel trunk\" of the mesocolon corresponds to the level of lymph node dissection. After removal of the resected colonic segment a handsewn or stapler end-to-end or side-to-side colonic anastomosis is performed.",[9,17],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Sigmoid colon resection","This procedure is performed for tumours in sigmoid colon. Corresponding sigmoid arteries are divided at their origin. Left colic artery and superior rectal artery are preserved. Inferior mesenteric vein is divide close to the left colic artery. Proximal and distal margin compose 10 cm from the tumour. Mesocolic fascia is preserved and the length of the \"vessel trunk\" of the mesocolon corresponds to the level of lymph nodes dissection. After removal of the resected colonic segment a handsewn end-to-end or side-to-side or stapler colonic anastomosis is performed.",[9,17],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Distal sigmoid colon resection or anterior resection","This procedure is performed for tumours in distal sigmoid colon or rectosigmoid junction. Superior rectal artery is divided below the origin of left colic artery. Left colic artery is preserved. Inferior mesenteric vein is divide close to the left colic artery. The colon is divided about 10 cm proximal and 5 cm distal to the tumour. Mesocolic fascia is preserved and the length of the \"vessel trunk\" of the mesocolon corresponds to the level of lymph node dissection. After removal of the resected colonic segment handsewn or stapler colo-rectal anastomosis is performed.",[9,17],[37],{"name":38,"affiliation":39,"role":40},"Peter Tsarkov, Ph.D","I.M. Sechenov First Moscow State Medical University","STUDY_DIRECTOR",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":27,"email":46},"Vladimir Balaban, Ph.D","CONTACT","+79889478358","balaban@kkmx.ru",{"name":48,"role":44,"phone":49,"phoneExt":27,"email":50},"Inna Tulina, Ph.D","+79264086672","tulina@kkmx.ru",[52],{"facility":53,"status":54,"city":55,"state":27,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Clinic of coloproctology and minimally invasive surgery","RECRUITING","Moscow","119435","Russia","RU",{"type":60,"coordinates":61},"Point",[62,63],37.61781,55.75204,{"lat":63,"lon":62},[66,67,68],{"name":43,"role":44,"phone":45,"phoneExt":27,"email":46},{"name":48,"role":44,"phone":49,"phoneExt":27,"email":50},{"name":69,"role":70,"phone":27,"phoneExt":27,"email":27},"Mihail Mutyk","SUB_INVESTIGATOR",{"type":72,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[74,75],{"name":39,"class":6},{"name":76,"class":6},"G.V. Bondar Republican Cancer Center","100390472","d2-vs-d3-lymph-node-dissection-for-left-colon-cancer-100390472",false,"NCT04364373","D2 vs D3 Lymph Node Dissection for Left Colon Cancer","D2 vs D3 Lymph Node Dissection for Left Colon Cancer: Multicenter Randomize Control Trial (DILEMMA)","DILEMMA","Inclusion Criteria:\n\n1. Agreement of the patient to participate in trial\n2. Colon cancer (only adenocarcinoma )\n3. The tumor located between the splenic flexure and rectosigmoid junction\n4. cT3-Т4а,b\n5. cN0-2\n6. cM0\n7. Tolerance of chemotherapy\n8. ASA 1-3\n\nExclusion Criteria:\n\n1. сТis - Т2, сТ4b (tail of the pancreas, stomach, small bowel, ureter, urinary bladder)\n2. Preoperative complications of the tumor (perforation and full bowel 3. obstruction)\n3. Previous radiotherapy or chemotherapy\n4. Synchronous or metachronous tumors\n5. Women during Pregnancy or breast feeding period","ALL","18 Years","75 Years",{"count":89,"type":90},1381,"ESTIMATED","INTERVENTIONAL",[93],"NA","The efficiency of the D3 lymph node dissection is still controversial for left colon cancer patients. This study will try find difference in 5-year overall survival between D2 and D3 lymph node dissection. Investigation of the functional and short-term outcomes will clarify safety of the D3 lymph node dissection.",[96],"Colon Cancer",[98,99,100,101,102,103],"D2","D3","lymph node dissection","complete mesocolic excision","left colon cancer","CME","2026-08-14",{"date":106,"type":107},"2026-08-17","ACTUAL",{"date":109,"type":107},"2020-03-31",{"date":111,"type":90},"2033-12-31",{"name":5,"class":6},1]