[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602621":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":28,"studyPopulation":29,"armGroups":30,"interventions":24,"overallOfficials":36,"centralContacts":41,"locations":51,"responsibleParty":72,"collaborators":24,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":24,"studyType":87,"phases":24,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":54,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":24},[9],{"measure":10,"description":11,"timeFrame":12},"Nature and severity of sensory and neuropsychological disturbances","Specify the nature and severity of sensory and neuropsychological disturbances (cognitive, executive, emotional, behavioral and neuropsychiatric) according to the patient's genotype.","12 Months",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"Correlations between sensory and neuropsychological measures","Analyze the correlations between sensory (retinal\u002Fvisual) and neuropsychological measures, in order to determine if retinal defects represent a signature of neuropsychological impairment severity.","24 Months",{"measure":19,"description":20,"timeFrame":17},"Correlation between neuropsychological and functional imaging parameters","Analyze correlation between neuropsychological and functional imaging parameters.",{"measure":22,"description":23,"timeFrame":17},"Correlation between sensory and functional imaging parameters","Analyze correlation between sensory and functional imaging parameters.",null,{"allocation":24,"interventionModel":24,"interventionModelDescription":24,"primaryPurpose":24,"observationalModel":26,"timePerspective":27,"maskingInfo":24},"COHORT","PROSPECTIVE","We propose a unique longitudinal study in which DMD children aged 5-12 years old will first be engaged in a deep evaluation of a range of cognitive, behavioral, physiological and neural functions (identification of biomarkers based on ERG) and an eligible subgroup of patients will then enter a second study phase (last 2 years) aimed at developing targeted cognitive remediation strategies:\n\n1. Deep evaluation with research of correlation between DMD patients' genotype and neurological\u002Fneuropsychological phenotype: - the nature and severity of the cognitive\u002Fexecutive\u002Fbehavioral deficits, - the retinal\u002Fvisual alterations, - functional brain imaging.\n2. Targeted cognitive remediation strategies in the same patients, to alleviate the identified neuropsychological and behavioral disturbances. We will place a particular focus on the socio-cognitive and executive weaknesse.","DMD diagnosis confirmed by a genetic analysis",[31,33],{"label":32,"type":24,"description":29,"interventionNames":24},"Group 1: PHASE 1",{"label":34,"type":24,"description":35,"interventionNames":24},"Group 2: PHASE 2","DMD diagnosis confirmed whose neuropsychological data are eligible for remediation",[37],{"name":38,"affiliation":39,"role":40},"Isabelle DESGUERRE, MD, PhD","Hôpital Universitaire Necker - Enfants Malades","PRINCIPAL_INVESTIGATOR",[42,47],{"name":38,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","01 44 49 48 56","+33","isabelle.desguerre@aphp.fr",{"name":48,"role":43,"phone":49,"phoneExt":45,"email":50},"Aminata TRAORE, Project manager","01 42 19 27 34","aminata.traore6@aphp.fr",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Hôpital Necker Enfants Malades","RECRUITING","Paris","Île-de-France Region","75015","France","FR",{"type":61,"coordinates":62},"Point",[63,64],2.3488,48.85341,{"lat":64,"lon":63},[67,68,71],{"name":38,"role":43,"phone":44,"phoneExt":45,"email":46},{"name":69,"role":43,"phone":49,"phoneExt":45,"email":70},"Aminata TRAORE, Project advisor","Aminata.traore6@aphp.fr",{"name":38,"role":40,"phone":24,"phoneExt":24,"email":24},{"type":73,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100602621","decoding-central-defects-in-dystrophinopathies-from-diagnostic-to-remediation-100602621",false,"NCT07125898","Decoding Central Defects in Dystrophinopathies From Diagnostic to Remediation","DECODYS","Inclusion Criteria:\n\n* French citizenship, affiliated to the French Social Security,\n* 5 to 12 years old,\n* DMD diagnosis confirmed by a genetic analysis predicting breaking in the reading frame of the DMD gene with knowledge of the limits of the mutation,\n* Follow-up in a French referral or a skills center belonging to Filnemus.\n\nExclusion Criteria:\n\n* Severe intellectual deficiency with IQ \\\u003C 55, and IQ \\\u003C 70 for the deep neurocognitive evaluation (executive and socio-cognitive evaluation),\n* Cataract except if operated (pseudophakic),\n* High intraocular pressure,\n* Cardiac dysfunction with left ventricular ejection fraction \\\u003C 35%,\n* Respiratory dysfunction with force vital capacity \\\u003C 70%,\n* Difficulties in fine motor skills with D3 MFM scale \\\u003C 75%\n* Treatment with methylphenidate: In case of hyperactive patients, the treatment will be transitorily interrupted the week before testing.","ALL","5 Years","12 Years",{"count":85,"type":86},110,"ESTIMATED","OBSERVATIONAL","The study aims to identify a genotype\u002Fphenotype correlation by analyzing more finely the neurodevelopmental disorders in DMD patients.",[90],"Dystrophinopathies",[92,93,94],"Cognitive deficits","Autism-spectrum disorders","Attention deficit hyperactivity Disorder","2026-09-17",{"date":97,"type":98},"2026-09-22","ACTUAL",{"date":100,"type":98},"2026-09-16",{"date":102,"type":86},"2031-03",{"name":5,"class":6},1]