[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657811":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":42,"studyPopulation":43,"armGroups":44,"interventions":38,"overallOfficials":51,"centralContacts":56,"locations":38,"responsibleParty":62,"collaborators":38,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":38,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":38,"studyType":80,"phases":38,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":90,"whyStopped":38,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":38},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":38},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Prevalence of Demodex infestation","Proportion of participants with Demodex mites detected by standardized skin surface biopsy.","Baseline",{"measure":14,"description":15,"timeFrame":12},"Mean Demodex density","Mean number of Demodex mites per cm² of skin surface.",{"measure":17,"description":18,"timeFrame":12},"Mean in vitro survival time of Demodex mites","Mean survival time in minutes of live Demodex mites exposed to the medicinal herbal extracts.",[20,23,26,29,32,35],{"measure":21,"description":22,"timeFrame":12},"Distribution of Demodex species","Frequency and percentage of Demodex folliculorum and Demodex brevis among positive cases identified by PCR.",{"measure":24,"description":25,"timeFrame":12},"Mean mite density according to acne severity","Mean Demodex density (mites\u002Fcm²) in mild, moderate, and severe acne groups according to the Global Acne Grading System.",{"measure":27,"description":28,"timeFrame":12},"Mean survival time at 5% herbal extract concentration","Mean survival time in minutes of Demodex mites exposed to 5% concentration of the herbal extract",{"measure":30,"description":31,"timeFrame":12},"Mean survival time at 10% herbal extract concentration","Mean survival time in minutes of Demodex mites exposed to 10% concentration of the herbal extract.",{"measure":33,"description":34,"timeFrame":12},"Mean survival time at 25% herbal extract concentration","Mean survival time in minutes of Demodex mites exposed to 25% concentration of the herbal extract.",{"measure":36,"description":37,"timeFrame":12},"Mean survival time at 50% herbal extract concentration","Mean survival time in minutes of Demodex mites exposed to 50% concentration of the herbal extract",null,{"allocation":38,"interventionModel":38,"interventionModelDescription":38,"primaryPurpose":38,"observationalModel":40,"timePerspective":41,"maskingInfo":38},"CASE_CONTROL","CROSS_SECTIONAL","Demodex mites may contribute to treatment-resistant acne. This observational study will include patients with clinically diagnosed acne and age- and sex-matched healthy controls.\n\nSkin samples will be collected using standardized skin surface biopsy. Mite density will be calculated microscopically, species will be identified by PCR, and live mites will be exposed to different concentrations of medicinal herbal extracts to determine survival time.","Adult patients with clinically diagnosed acne vulgaris attending the dermatology outpatient clinic at Assiut University Hospital, and age- and sex-matched healthy controls.",[45,48],{"label":46,"type":38,"description":47,"interventionNames":38},"Patients with Acne","Patients with clinically diagnosed acne of any severity (mild, moderate, or severe) who will undergo standardized skin surface biopsy for Demodex detection and density calculation.",{"label":49,"type":38,"description":50,"interventionNames":38},"Healthy Controls","Age- and sex-matched healthy individuals without dermatosis.",[52],{"name":53,"affiliation":54,"role":55},"Magda M Atiaa, prof","Medical parasitology Department, Assiut University Hospitals","STUDY_CHAIR",[57],{"name":58,"role":59,"phone":60,"phoneExt":38,"email":61},"Marina G shawqy, Resident","CONTACT","+20 12 76121351","Marina.gamil@aun.edu.eg",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"PRINCIPAL_INVESTIGATOR","Marina Gamil Shawqi","Resident Physician, Department of medical Parasitology","100657811","demodex-mites-in-acne-patients-and-herbal-extract-susceptibility-100657811",false,"NCT07845149","Demodex Mites in Acne Patients and Herbal Extract Susceptibility","Detection and Molecular Identification of Demodex Species in Acne Patients and Its In Vitro Susceptibility to Some Medicinal Herbal Extracts","Inclusion Criteria:\n\n* \\- Age 18 to 45 years\n* Clinically diagnosed acne vulgaris of any severity (cases)\n* Age- and sex-matched healthy individuals without dermatosis or pruritus (controls)\n* Written informed consent\n\nExclusion Criteria:\n\n* \\- Use of topical anti-acne or acaricidal treatments within the last 4 weeks\n* Use of systemic antibiotics or systemic retinoids within the last 3 months",true,"ALL","18 Years","45 Years",{"count":78,"type":79},80,"ESTIMATED","OBSERVATIONAL","This case-control study aims to detect the presence and density of Demodex mites in patients with acne, identify the species using molecular methods, and evaluate the in vitro survival time of live mites exposed to medicinal herbal extracts.",[83,84],"Acne","Demodex Infestation",[83,86,87,88,89],"Assiut","In vitro susceptibility","Demodex","Herbal extracts","NOT_YET_RECRUITING","2026-09-22",{"date":93,"type":94},"2026-09-28","ACTUAL",{"date":96,"type":79},"2026-09-26",{"date":98,"type":79},"2028-02-10",{"name":5,"class":6}]