[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486732":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":99,"collaborators":102,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":110,"sex":116,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":26,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Motivational Interview Intervention","EXPERIMENTAL","This arm involves three 45-minute sessions on motivational interviewing targeting sensitivity to social reward.",[13],"Behavioral: Motivational Interviewing",{"label":15,"type":16,"description":17,"interventionNames":18},"Active Control Intervention","ACTIVE_COMPARATOR","This arm involves three 45-minute sessions on didactic training on nutrition.",[19],"Behavioral: Nutrition Didactic Training",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Motivational Interviewing","Three motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Nutrition Didactic Training","The Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Junghee Lee, PhD","CONTACT","205-934-8205","jungheelee@uabmc.edu",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Andrew Meddaugh, BA","205-934-8203","ajmeddaugh@uabmc.edu",[42,69],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-86.80249,33.52066,{"lat":53,"lon":52},[56,57,58,60,63,65,67],{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":33,"role":59,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":61,"role":62,"phone":26,"phoneExt":26,"email":26},"Adrienne C Lahti, MD","SUB_INVESTIGATOR",{"name":64,"role":62,"phone":26,"phoneExt":26,"email":26},"Alison Thomas, PhD",{"name":66,"role":62,"phone":26,"phoneExt":26,"email":26},"Caitlin W Clevenger, PhD",{"name":68,"role":62,"phone":26,"phoneExt":26,"email":26},"Gerhard S Hellemann, PhD",{"facility":70,"status":43,"city":71,"state":72,"zip":73,"country":47,"countryCode":48,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"University of California Los Angeles","Los Angeles","California","90095",{"type":50,"coordinates":75},[76,77],-118.24368,34.05223,{"lat":77,"lon":76},[80,84,88,90,92,93,95,97],{"name":81,"role":34,"phone":82,"phoneExt":26,"email":83},"Rebecca Zornitsky, MS","424-225-1779","zornitsky@mednet.ucla.edu",{"name":85,"role":34,"phone":86,"phoneExt":26,"email":87},"Joseph Ventura, PhD","310-206-3142","jventura@mednet.ucla.edu",{"name":89,"role":59,"phone":26,"phoneExt":26,"email":26},"Keith H Nuechterlein, PhD",{"name":91,"role":59,"phone":26,"phoneExt":26,"email":26},"Michael F Green, PhD",{"name":85,"role":62,"phone":26,"phoneExt":26,"email":26},{"name":94,"role":62,"phone":26,"phoneExt":26,"email":26},"Kenneth Subotnik, PhD",{"name":96,"role":62,"phone":26,"phoneExt":26,"email":26},"Amy M Jimenez, PhD",{"name":98,"role":62,"phone":26,"phoneExt":26,"email":26},"Lena M Reddy, PhD",{"type":59,"investigatorFullName":100,"investigatorTitle":101,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Junghee Lee","Associate Professor",[103,105],{"name":104,"class":6},"University of California, Los Angeles",{"name":106,"class":107},"National Institute of Mental Health (NIMH)","NIH","100486732","determining-the-role-of-social-reward-learning-in-social-anhedonia-100486732",false,"NCT05617898","Determining the Role of Social Reward Learning in Social Anhedonia","Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach","SAMI","Inclusion Criteria:\n\n* Age 18-35 years\n* A first episode of a psychotic illness that began within the past three years\n* Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder\n* Taking 2nd generation antipsychotic medications\n* Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading\n* Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning\n* Sufficient fluency in English to comprehend testing procedures\n* Corrected vision of at least 20\u002F30\n\nExclusion Criteria:\n\n* No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)\n* No evidence of moderate or severe alcohol or substance use disorder in the past 3 months\n* No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury\n* For females: no current pregnancy\n* No sedatives or anxiolytics on the day of assessment\n* No medication change 3 weeks prior to enrollment","ALL","18 Years","35 Years",{"count":120,"type":121},152,"ESTIMATED","INTERVENTIONAL",[124],"NA","This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.",[127],"Psychosis",[129],"social anhedonia, social reward learning, fMRI, sensitivity to reward","2026-07-24",{"date":132,"type":133},"2026-07-27","ACTUAL",{"date":135,"type":133},"2023-06-14",{"date":137,"type":121},"2027-11",{"name":5,"class":6},2]