[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650153":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":49,"collaborators":52,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":11,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":81,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Psychosocial intervention group","EXPERIMENTAL",null,[13],"Behavioral: Psychosocial intervention group",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":11},"BEHAVIORAL","Over 16 weeks, participants and their parent\u002Flegal guardian(s)\u002Fcaregiver(s) will attend weekly hour long family-based psychosocial intervention to work on their top 2 modifiable SSD-risk factors targeted by the risk reduction therapy (RRT)",[9],[20],{"name":21,"affiliation":5,"role":22},"Yizhou Ma, PhD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":11,"email":27},"CONTACT","713-486-2700","Yizhou.Ma@uth.tmc.edu",{"name":29,"role":25,"phone":30,"phoneExt":11,"email":31},"L. Elliot Hong, MD","713-486-2500","L.Elliot.Hong@uth.tmc.edu",[33],{"facility":34,"status":11,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"The University of Texas Health Science Center at Houston","Houston","Texas","77030","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-95.36327,29.76328,{"lat":44,"lon":43},[47,48],{"name":21,"role":25,"phone":26,"phoneExt":11,"email":27},{"name":29,"role":25,"phone":30,"phoneExt":11,"email":31},{"type":22,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Yizhou Ma","Instructor",[53],{"name":54,"class":55},"National Institutes of Health (NIH)","NIH","100650153","developing-biomarker-supported-schizophrenia-spectrum-disorder-ssd-prevention-100650153",false,"NCT07743645","Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention","Developing Biomarker-Supported SSD Prevention","Inclusion Criteria:\n\n* Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and\u002For parent\u002Flegal guardian report and confirmed by a structured interview\n* screening positive for two or more risk factors targeted by the intervention\n* Participants and parent(s)\u002Flegal guardian(s) agree to participate\n* psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.\n\nExclusion Criteria:\n\n* Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview\n* Current or past antipsychotic medication use to specifically treat a psychotic disorder\n* major medical and neurological conditions\n* moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;\n* current drug or alcohol use that impacts functioning and study engagement;\n* Not able to give assent, permission, or consent.\n* Not able to undergo MRI.",true,"ALL","9 Years","19 Years",{"count":68,"type":69},100,"ESTIMATED","INTERVENTIONAL",[72],"NA","The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns",[75,76,77],"Prevention","Risk Factors for Mental Illness","Family History of Schizophrenia Spectrum Disorder",[79,75,80],"Risk Reduction Therapy (RRT)","family history of schizophrenia spectrum disorder","NOT_YET_RECRUITING","2026-07-30",{"date":84,"type":85},"2026-08-04","ACTUAL",{"date":87,"type":69},"2026-10-01",{"date":89,"type":69},"2031-04-01",{"name":5,"class":6},1]