[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646360":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":19,"locations":24,"responsibleParty":85,"collaborators":87,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":10,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":10,"studyType":105,"phases":10,"briefSummary":106,"conditions":107,"keywords":113,"overallStatus":116,"whyStopped":10,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Peking University Cancer Hospital & Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Screening Group",null,"Adults aged 18 to 80 years who have already been scheduled for or referred to colonoscopy as part of routine clinical care, physical examination, or screening pathways at participating medical institutions in China will be enrolled. The study will not invite, organize, require, or otherwise arrange colonoscopy. Participation in the study will only involve informed consent, completion of a standardized questionnaire before colonoscopy, and collection of routine clinical colonoscopy and pathology data from medical records. No randomization or experimental intervention will be performed.",[13,16],{"name":14,"affiliation":5,"role":15},"Zhonghu He, PhD","PRINCIPAL_INVESTIGATOR",{"name":17,"affiliation":18,"role":15},"Haixing Wang, PhD","The First Affiliated Hospital of Xiamen University",[20],{"name":14,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","+86-010-88196762","Zhonghuhe@foxmail.com",[25,40,56,69],{"facility":5,"status":10,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Beijing","Beijing Municipality","100142","China","CN",{"type":32,"coordinates":33},"Point",[34,35],116.39723,39.9075,{"lat":35,"lon":34},[38,39],{"name":14,"role":21,"phone":22,"phoneExt":10,"email":23},{"name":14,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":41,"status":10,"city":42,"state":43,"zip":44,"country":29,"countryCode":30,"cosmosGeoPoint":45,"geoPoint":49,"contacts":50},"Fujian Provincial Hospital","Fuzhou","Fujian","350001",{"type":32,"coordinates":46},[47,48],119.30611,26.06139,{"lat":48,"lon":47},[51,55],{"name":52,"role":21,"phone":53,"phoneExt":10,"email":54},"Xiaoling Zheng, PhD","+86-0591-87557768","fjzhengxl@163.com",{"name":52,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":18,"status":10,"city":57,"state":43,"zip":58,"country":29,"countryCode":30,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Xiamen","361003",{"type":32,"coordinates":60},[61,62],118.08187,24.47979,{"lat":62,"lon":61},[65,68],{"name":17,"role":21,"phone":66,"phoneExt":10,"email":67},"+86-0592-2132222","wang.haixing.xmu@outlook.com",{"name":17,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":70,"status":10,"city":71,"state":72,"zip":73,"country":29,"countryCode":30,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"People's Hospital of Ningxia Hui Autonomous Region","Yinchuan","Ningxia","750001",{"type":32,"coordinates":75},[76,77],106.27306,38.46806,{"lat":77,"lon":76},[80,84],{"name":81,"role":21,"phone":82,"phoneExt":10,"email":83},"Shengjuan Hu, Master of Medicine","+86-0951-5920120","hsj.judy@163.com",{"name":81,"role":15,"phone":10,"phoneExt":10,"email":10},{"type":86,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[88,89,90],{"name":18,"class":6},{"name":41,"class":6},{"name":70,"class":6},"100646360","development-and-validation-of-a-colorectal-cancer-diagnostic-model-100646360",false,"NCT07692555","Development and Validation of a Colorectal Cancer Diagnostic Model","Development and Validation of a Colorectal Cancer Diagnostic Model: A Multicenter Study in China (CCDM-CN)","Inclusion Criteria:\n\n* Age between 18 and 80 years at the time of enrollment.\n* Already scheduled to undergo colonoscopy according to routine clinical care, physical examination, or screening pathways at a participating medical institution.\n* No prior history of colorectal cancer or advanced colorectal neoplasia.\n* No contraindications to colonoscopy (as determined by the treating physician).\n* Able to understand the study information and complete the colorectal cancer risk-factor questionnaire independently or with appropriate assistance.\n* Willing to provide informed consent for completion of the questionnaire and for collection of routine clinical colonoscopy, pathology, and related medical-record data.\n\nExclusion Criteria:\n\n* The baseline colorectal cancer risk-factor questionnaire is not completed, or considered invalid because of substantial missing or inconsistent information.\n* The scheduled index colonoscopy is cancelled, not performed, or not completed regardless of the underlying reason (e.g., inadequate bowel preparation).\n* Incomplete or unavailable colonoscopy or pathology data after the procedure.\n* Refusal or withdrawal of informed consent.",true,"ALL","18 Years","80 Years",{"count":103,"type":104},20000,"ESTIMATED","OBSERVATIONAL","This is a multicenter, observational study designed to develop and validate a diagnostic model for colorectal cancer and advanced colorectal neoplasia among adults undergoing routine-care colonoscopy in the Chinese population.\n\nThe study will enroll adults aged 18 to 80 years who have already been scheduled or planned to undergo colonoscopy according to routine clinical care, physical examination, or screening pathways at participating medical institutions. The study will not invite, organize, require, or otherwise arrange colonoscopy for any participant. Colonoscopy, bowel preparation, anesthesia assessment, biopsy, pathology examination, and subsequent clinical management will be performed solely according to the existing clinical pathway of each participating institution.\n\nAfter informed consent, participants will be invited to complete a standardized electronic questionnaire before their scheduled colonoscopy. The questionnaire will collect self-reported information on demographic characteristics, lifestyle factors, environmental exposures, personal medical history, family history of colorectal cancer, prior colonoscopy history, and gastrointestinal symptoms. The study team will also abstract colonoscopy and pathology results from medical records. No additional biological specimens will be collected for research purposes.\n\nThe primary clinical outcome is prevalent colorectal advanced neoplasia, defined as colorectal cancer, advanced colorectal adenoma, or advanced colorectal serrated lesion identified through colonoscopy and associated pathology. Statistical and machine-learning approaches will be used to develop and validate diagnostic models. Model performance will be evaluated by discrimination, calibration, and clinical net benefit in internal validation and multicenter external validation.",[108,109,110,111,112],"Colorectal Cancer","Advanced Neoplasia","Prediction Models","Risk Stratification","Precision Screening",[114,115,112,111],"Colorectal cancer","Colorectal Advanced Neoplasia","NOT_YET_RECRUITING","2026-07-21",{"date":119,"type":120},"2026-07-23","ACTUAL",{"date":122,"type":104},"2026-07-15",{"date":124,"type":104},"2029-07-01",{"name":5,"class":6},4]