[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659656":3},{"organization":4,"outcomesModule":7,"designInfo":46,"detailedDescription":45,"studyPopulation":49,"armGroups":50,"interventions":45,"overallOfficials":45,"centralContacts":57,"locations":63,"responsibleParty":80,"collaborators":45,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":86,"sex":92,"minAge":93,"maxAge":45,"enrollmentInfo":94,"targetDuration":45,"studyType":97,"phases":45,"briefSummary":98,"conditions":99,"keywords":104,"overallStatus":66,"whyStopped":45,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":45},[9],{"measure":10,"description":11,"timeFrame":12},"Any postoperative delirium within the first 3 days after surgery","The proportion of patients with at least one positive CAM-score on postoperative day 1-3 (yes\u002Fno).","Postoperative day 1-3",[14,18,21,25,28,31,35,39,42],{"measure":15,"description":16,"timeFrame":17},"Any postoperative delirium within the first 7 days after surgery","The proportion of patients with at least one positive CAM-score on postoperative day 1-7 (yes\u002Fno).","Postoperative day 1-7",{"measure":19,"description":20,"timeFrame":17},"Maximum severity of postoperative delirium","Maximum severity of postoperative delirium based on CAM score (mild, moderate, severe)",{"measure":22,"description":23,"timeFrame":24},"Postoperative pain in the PACU","NRS (0-10) at rest and during mobilisation in the PACU","PACU stay",{"measure":26,"description":27,"timeFrame":24},"Postoperative opioid use in the PACU","Cumulative opioid consumption during the PACU stay (oral morphine milligram equivalents)",{"measure":29,"description":30,"timeFrame":17},"Need for antipsychotic medication","Any new use of haloperidol, olanzapine, risperidone, quetiapine or similar medication (yes\u002Fno)",{"measure":32,"description":33,"timeFrame":34},"Intraoperative treatment with moderate-dose vasopressors","Intraoperative dose of norepinephrine \\> 0,1ug\u002Fkg\u002Fmin (yes\u002Fno)","Intraoperative period",{"measure":36,"description":37,"timeFrame":38},"Perioperative treatment of bradycardia","Perioperative treatment of bradycardia with atropin (yes\u002Fno)","Intraoperative period and PACU stay",{"measure":40,"description":41,"timeFrame":24},"Postoperative vasopressor treatment","Any vasopressor use in the PACU (yes\u002Fno)",{"measure":43,"description":44,"timeFrame":24},"Length of stay in the PACU","Length of stay in the PACU (min)",null,{"allocation":45,"interventionModel":45,"interventionModelDescription":45,"primaryPurpose":45,"observationalModel":47,"timePerspective":48,"maskingInfo":45},"CASE_CONTROL","PROSPECTIVE","Study participants will be selected from patients undergoing surgery for hip fracture at the Department of Orthopedics, Aarhus University Hospital, Denmark. The study population will include patients aged 65 years or older undergoing operative treatment in either general or spinal anesthesia. Patients will be identified consecutively during the predefined pre-implementation and post-implementation study periods. In the post-implementation period, eligible patients will receive perioperative dexmedetomidine prophylaxis unless contraindications or other clinical reasons for omission are present. Patients with severe liver failure, acute neurological conditions, or second- or third-degree atrioventricular block without a pacemaker will not receive dexmedetomidine",[51,54],{"label":52,"type":45,"description":53,"interventionNames":45},"Pre-implementation","Patients undergoing hip fracture surgery before implementation of intraoperative dexmedetomidine prophylaxis.",{"label":55,"type":45,"description":56,"interventionNames":45},"Post-implementation \u002F Dexmedetomidine prophylaxis","Patients undergoing hip fracture surgery after implementation of intraoperative dexmedetomidine prophylaxis. Dexmedetomidine prophylaxis is initiated after induction of general anesthesia or after spinal anesthesia has been established. Patients receive dexmedetomidine bolus 0.5 µg\u002Fkg ideal body weight followed by infusion 0.5 µg\u002Fkg\u002Fhour. The infusion is discontinued at the end of surgery.",[58],{"name":59,"role":60,"phone":61,"phoneExt":45,"email":62},"Peter G. Uhrbrand, MD, PhD","CONTACT","+4530615082","petuhr@rm.dk",[64],{"facility":65,"status":66,"city":67,"state":45,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":77},"Department of Anesthesiology, Aarhus University Hospital","RECRUITING","Aarhus","8200","Denmark","DK",{"type":72,"coordinates":73},"Point",[74,75],10.21076,56.15674,{"lat":75,"lon":74},[78],{"name":59,"role":60,"phone":79,"phoneExt":45,"email":62},"004530615082",{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"SPONSOR_INVESTIGATOR","Peter Gaarsdal Uhrbrand","Principal and sponsor-investigator, MD, PhD","100659656","dexmedetomidine-for-prevention-of-delirium-after-hip-fracture-surgery-100659656",false,"NCT07867899","Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery","Intraoperative Dexmedetomidine for Prevention of Postoperative Delirium in Patients Undergoing Hip Fracture Surgery: a Pre-post Study","DEXLIR","Inclusion Criteria:\n\n* Patients at least 65 years of age undergoing surgery for hip fracture in general or spinal anesthesia\n* Treated during the defined pre- or post-implementation period\n\nExclusion Criteria:\n\n* Known hypersensitivity to dexmedetomidine\n* Second- or third-degree AV block without pacemaker\n* Acute cerebral conditions with potentially impaired cerebral autoregulation\n* Acute or chronic liver failure","ALL","65 Years",{"count":95,"type":96},242,"ESTIMATED","OBSERVATIONAL","Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications. Patients with hip fracture are often elderly, acutely admitted, in pain, and have multiple comorbidities, all of which increase the risk of delirium.\n\nThis study evaluates whether implementation of intraoperative dexmedetomidine prophylaxis reduces postoperative delirium in patients undergoing hip fracture surgery. The study will compare patients treated before and after implementation of dexmedetomidine prophylaxis.",[100,101,102,103],"Delirium - Postoperative","Delirium Prevention","Dexmedetomidine","Dexmedetomidine Infusion",[105,106,107,102,108,109,110],"Hip fracture","Surgery","Postoperative","Delirium prevention","Pre-post intervention","Geriatric anesthesia","2026-10-05",{"date":113,"type":114},"2026-10-09","ACTUAL",{"date":116,"type":114},"2026-10-01",{"date":118,"type":96},"2027-04-14",{"name":82,"class":6},1]