[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654943":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":16,"studyPopulation":22,"armGroups":23,"interventions":16,"overallOfficials":16,"centralContacts":16,"locations":16,"responsibleParty":30,"collaborators":16,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":16,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":16,"enrollmentInfo":43,"targetDuration":16,"studyType":46,"phases":16,"briefSummary":47,"conditions":48,"keywords":16,"overallStatus":50,"whyStopped":16,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":16},{"fullName":5,"class":6},"Sohag University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":16},[9],{"measure":10,"description":11,"timeFrame":12},"occurrence of delirium during the ICU admission","main end point: occurrence of delirium during the ICU admission , defined as at least one positive CAM-ICU assessment.","Within 12 hours of intubation",[14,18],{"measure":15,"description":16,"timeFrame":17},"Number of Ventilator-free days (VFDs)",null,"6 months",{"measure":19,"description":16,"timeFrame":17},"duration of ICU stay (LOS)",{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":6,"timePerspective":21,"maskingInfo":16},"RETROSPECTIVE","this retrospective observational trial was conducted in a 40-bed intensive care unit at sohag university hospital between January 2024, to ,march 2026. The Institutional Review Board granted approval for the trial protocol and informed consent was waived",[24,27],{"label":25,"type":16,"description":26,"interventionNames":16},"EGDS Group: Patients managed per the institutional EGDS protocol initiated within 12 hours of intuba","· EGDS Group: Patients managed per the institutional EGDS protocol initiated within 12 hours of intubation. The protocol mandated: a) Primary sedative: Dexmedetomidine infusion (loading dose optional, maintenance 0.2-1.5 µg\u002Fkg\u002Fhr). b) Goal: Target Richmond Agitation-Sedation Scale (RASS) score of 0 to -2. c) Adjunct Analgesia: Scheduled acetaminophen and opioid infusion (e.g., fentanyl) for pain control (CPOT target \\\u003C3). d) Protocol Deviations: Propofol was allowed as a rescue for refractory agitation (RASS \\>+2) after optimizing analgesia",{"label":28,"type":16,"description":29,"interventionNames":16},"Conventional Sedation Group: Patients managed at the discretion of the treating intensivist without","Conventional Sedation Group: Patients managed at the discretion of the treating intensivist without a mandated protocol. This typically involved continuous infusions of propofol and\u002For midazolam, with or without dexmedetomidine, with variable RASS targets",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"PRINCIPAL_INVESTIGATOR","Islam Mokhtar Ahmed","Assistant professor of Anesthesia and Intensive Care","100654943","dexmedetomidine-for-sedation-in-patients-requiring-mechanical-ventilation-is-associated-with-a-lower-incidence-of-delirium-100654943",false,"NCT07806188","Dexmedetomidine for Sedation in Patients Requiring Mechanical Ventilation is Associated With a Lower Incidence of Delirium","Dexmedetomidine for Sedation in Patients Requiring Mechanical Ventilation is Associated With a Lower Incidence of Delirium : A Retrospective Study","Inclusion Criteria:\n\n* Consecutive adult patients aged 18 years or older who required invasive mechanical ventilation for more than 24 hours.\n\nExclusion Criteria:\n\n* Neurological primary admission such as stroke or traumatic brain injury.\n* Active seizures or alcohol withdrawal at admission.\n* Prior dementia or severe cognitive impairment.\n* Mechanical ventilation \\\u003C24 hours.\n* Death within 48 hours of admission.\n* Missing essential sedation or delirium data.","ALL","18 Years",{"count":44,"type":45},412,"ESTIMATED","OBSERVATIONAL","This retrospective cohort study will include 412 adults mechanically ventilated \\>24 hours in intensive care unit in sohag university hospital between 2024 and 2026). Participants will be assigned to either, EGDS group ( equal to 208 ) or conventional sedation group (equal to 204 ). The main endpoint will be measured is the incidence of delirium in ICU , measured by the Confusion Assessment Method for the ICU (CAM-ICU). Secondary endpoints will be the number of the days free from ventilation at 28 days (VFDs), ICU length of stay (LOS) in the ICU, and the death during hospitalization.",[49],"Mechanical Ventilation","NOT_YET_RECRUITING","2026-09-01",{"date":53,"type":54},"2026-09-08","ACTUAL",{"date":56,"type":45},"2026-08-20",{"date":58,"type":45},"2027-01-20",{"name":5,"class":6}]