[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649225":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":49,"collaborators":11,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":11,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":84,"overallStatus":36,"whyStopped":11,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Loughborough University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Creatine","EXPERIMENTAL",null,[13],"Dietary Supplement: Creatine Monohydrate",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo control","PLACEBO_COMPARATOR",[18],"Dietary Supplement: Placebo control",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DIETARY_SUPPLEMENT","Creatine Monohydrate","Creatine monohydrate for 8 weeks (\\~6 g\u002Fday)",[9],{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":11},"Maltodextrin for 8 weeks (\\~10 g\u002Fday)",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Dr Tom Clifford","CONTACT","+44 (0) 1509228181","t.clifford@lboro.ac.uk",[35],{"facility":5,"status":36,"city":37,"state":11,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Loughborough","LE11 3TU","United Kingdom","UK",{"type":42,"coordinates":43},"Point",[44,45],-1.2,52.76667,{"lat":45,"lon":44},[48],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Tom Clifford","Reader in Exercise and Health Nutrition","100649225","dietary-supplements-and-middle-aged-women-creatine-100649225",false,"NCT07729930","Dietary Supplements and Middle Aged Women (Creatine)","The Effects of Dietary Supplements on Health and Wellbeing in Middle Aged Women","Inclusion Criteria:\n\n* Female\n* Aged 35-65 years old\n* Healthy, free from known disease\n* Non-smoker\n* BMI 18-30 kg\u002Fm2\n* Classified as recreationally active (meet the WHO guidelines for physical activity: complete at least 150-300 minutes of moderate intensity activity or 75-150 minutes of vigorous intensity activity a week, plus muscle strengthening activities 2 or more days a week) OR sedentary (do not meet the minimum activity guidelines but do occasional and\u002For incidental physical activity, e.g., walking to work, household activities).\n\nExclusion Criteria:\n\n* Currently have a musculoskeletal injury or diagnosed condition (CVD, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder)\n* Regularly taking prescription medication initiated in the last 3 months or unstable\n* Have initiated hormone replacement therapy within the last 3 months or unstable\n* Have an allergy to ingredients in the supplements or standardised breakfast\n* Pregnant or breastfeeding, or any other contradictions to consuming the study supplements\n* Lost more than 10% of body mass in the past 6 months or plan on trying to lose body mass during trial period\n* Currently consuming the supplements being investigated and unwilling to stop\n* Any known cognitive or visual impairments limiting ability to perform cognitive tests\n* Unwilling to maintain current diet and physical activity levels and report any change in health status",true,"FEMALE","35 Years","65 Years",{"count":65,"type":66},38,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study will examine the effects of combining different types of dietary supplements on various aspects of health and wellbeing in middle aged women. The main outcomes of the trial will be aspects of health and wellbeing that middle aged women report as increasingly problematic, such as joint pain, fatigue, sleep, and changes in body composition, strength, and inflammation. Participants will consume the supplement(s) or placebo for 8 weeks, and outcome measures will be assessed before and after supplementation.",[72,73,74,75,76,77,78,79,80,81,82,83],"Cognition","Muscle Strength","Fatigue Symptom","Blood Pressure and Augmentation Index","Body Composition Changes","Sleep","Gastrointestinal Comfort","Quality of Life","Joint Pain","Inflammation Biomarkers","Bone Metabolism Biomarkers","Menopause Symptoms",[9,85,86,87],"Middle aged women","Cognitive function","Dietary supplements","2026-07-21",{"date":90,"type":91},"2026-07-28","ACTUAL",{"date":93,"type":91},"2026-05-01",{"date":95,"type":66},"2028-11-01",{"name":5,"class":6},1]