[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652357":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":25,"locations":31,"responsibleParty":43,"collaborators":48,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Istanbul University - Cerrahpasa","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"septic schoc cohort",null,"Consecutive adult patients (≥18 years) admitted to the intensive care unit and diagnosed with septic shock according to the Surviving Sepsis Campaign (SSC) 2026 guideline, who have pre-existing central venous and arterial catheters. Patients are prospectively followed while receiving standard care, with serial measurements at hours 0, 6, 12, and 24 (time zero = vasopressor initiation). At hour 6, patients are classified into perfusion phenotypes based on capillary refill time (CRT) and oxygen extraction ratio (O₂ER): concordant normal, discordant with high O₂ER, discordant with low O₂ER, and concordant abnormal. The primary group of interest is the combined discordant phenotype (normalized CRT with abnormal O₂ER).",[13,14],"Diagnostic Test: Capillary refill time (CRT)","Diagnostic Test: Oxygen extraction ratio (O₂ER) assessment",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Capillary refill time (CRT)","Non-invasive, standardized bedside measurement of capillary refill time on the right index finger.",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Oxygen extraction ratio (O₂ER) assessment","Oxygen extraction ratio calculated as (SaO₂ - ScvO₂)\u002FSaO₂ from routinely obtained arterial and central venous blood gases.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Tugba Yesilyurt Dogu, Intensive Medicine Care Fellow","CONTACT","+9005535150847","tugbaayesilyurt@gmail.com",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"countryCode":10,"cosmosGeoPoint":37,"geoPoint":42,"contacts":10},"Basaksehir Cam and Sakura City Hospital","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":38,"coordinates":39},"Point",[40,41],28.94966,41.01384,{"lat":41,"lon":40},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":47,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","tugba yesilyurt dogu","Intensive Care Medicine Fellow","Başakşehir Çam & Sakura City Hospital",[49],{"name":47,"class":50},"OTHER_GOV","100652357","discordance-between-capillary-refill-time-and-oxygen-extraction-ratio-in-septic-shock-100652357",false,"NCT07774962","Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock","Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock: A Prospective Observational Cohort Study Evaluating Its Prevalence and Prognostic Value","DISCO-SHOCK","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of septic shock according to the Surviving Sepsis Campaign (SSC) 2026 guideline\n* Presence of both a central venous catheter and an arterial line\n\nExclusion Criteria:\n\n* Active bleeding\n* Ongoing extracorporeal membrane oxygenation (ECMO)\n* Raynaud phenomenon or significant peripheral vascular disease that makes capillary refill time measurement unreliable (e.g., critical ischemia, amputation, digital ulcer\u002Fnecrosis, or inability to measure on the right index finger)\n* Death within the first 6 hours\n* Inability to obtain hour-6 CRT or blood gas (phenotyping not possible)","ALL","18 Years",{"count":62,"type":63},100,"ESTIMATED","OBSERVATIONAL","In septic shock, restoring large-vessel (macrocirculatory) perfusion-reflected by a normal capillary refill time (CRT)-does not always mean that oxygen use at the tissue level has recovered. This mismatch, sometimes called loss of hemodynamic coherence, may be detectable by comparing CRT with the oxygen extraction ratio (O₂ER), a marker of how much oxygen the tissues are extracting from the blood. Patients whose CRT has normalized but whose O₂ER remains abnormal-either too high (suggesting oxygen delivery that is insufficient for demand) or too low (suggesting microcirculatory shunting)-are considered to have a \"discordant\" perfusion phenotype.\n\nThis prospective, single-center, observational cohort study aims to determine how often this CRT-O₂ER discordance occurs at the 6th hour of resuscitation in adult patients with septic shock, and whether it is associated with 28-day mortality. Approximately 100 consecutive adult patients diagnosed with septic shock (with pre-existing central venous and arterial catheters) will be followed. Clinical and laboratory measurements-including CRT, O₂ER, lactate, mottling score, and organ dysfunction scores-will be recorded at hours 0, 6, 12, and 24, with the main phenotype grouping performed at hour 6. The study is purely observational: CRT is a painless, non-invasive bedside measurement, and O₂ER is calculated from blood gas samples already drawn as part of routine care, so no additional interventions or blood draws are performed for research purposes.",[67,68],"Septic Shock","Sepsis",[70,71,72,73,74,75,76,77],"Capillary Refill Time","Oxygen Extraction Ratio","Tissue Perfusion","ScvO2","Microcirculation","Hemodynamic Coherence","Lactate","Observational Cohort Study","2026-08-15",{"date":80,"type":81},"2026-08-19","ACTUAL",{"date":83,"type":63},"2026-08-17",{"date":85,"type":63},"2027-07-17",{"name":5,"class":6},1]