[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653786":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":13,"overallOfficials":13,"centralContacts":13,"locations":23,"responsibleParty":42,"collaborators":44,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":13,"studyType":64,"phases":13,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":79,"whyStopped":13,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"King's College London","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Neuronal Autoantibodies","Differences in the prevalence, subtype, and functional characteristics of neuronal autoantibodies in serum and cerebrospinal fluid between participants with neuropsychiatric symptoms (NPS) and matched control participants.","From enrolment through to 1 year of follow-up.",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Participants with neuropsychiatric symptoms aged 16-100 will be recruited through participating clinical services, while control participants may be recruited through clinical services, research databases, social media, local research networks, and advertisements at collaborating universities and NHS sites.",[19,21],{"label":20,"type":13,"description":13,"interventionNames":13},"Participants with neuropsychiatric symptoms",{"label":22,"type":13,"description":13,"interventionNames":13},"Control Participants",[24,36],{"facility":25,"status":13,"city":26,"state":13,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":13},"South London and Maudsley NHS Foundation Trust","London","SE5 8AB","United Kingdom","UK",{"type":31,"coordinates":32},"Point",[33,34],-0.12574,51.50853,{"lat":34,"lon":33},{"facility":37,"status":13,"city":26,"state":13,"zip":38,"country":28,"countryCode":29,"cosmosGeoPoint":39,"geoPoint":41,"contacts":13},"King's College Hospital","SE5 9RS",{"type":31,"coordinates":40},[33,34],{"lat":34,"lon":33},{"type":43,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR",[45,46,48],{"name":25,"class":6},{"name":47,"class":6},"Francis Crick Institute",{"name":49,"class":6},"King's College Hospital NHS Trust","100653786","dissecting-immunological-and-autoimmune-mechanisms-of-neuropsychiatric-diseases-100653786",false,"NCT07791212","Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases","DIAMOND","INCLUSION CRITERIA\n\nParticipants with Neuropsychiatric symptoms\n\n* Age 16-100.\n* Current or previous neuropsychiatric symptoms within the last year.\n* Suspicion of immunological contribution to the aetiology of their neuropsychiatric symptoms.\n\nControl Participants\n\n* Age 16-100.\n* No current or previous self-report of neuropsychiatric symptoms within the last year.\n\nOptional Lumbar Puncture only:\n\n\\- Documented full blood count within the last 3 months with no clinically significant abnormalities.\n\nEXCLUSION CRITERIA\n\nAll Participants:\n\n* Unacceptable risk of harm to participant or study staff due to risk of behavioural disturbance.\n* Inability to have blood tests.\n\nOptional Lumbar Puncture only:\n\n* Significant lower spinal deformity (such as spina bifida), injury, or disease (such as stenosis) or previous lower spinal surgery.\n* Antiplatelet or anticoagulant therapy within the 14 days prior to Lumbar Puncture procedure.\n* Known or suspected clotting disorder.\n* Clinically significant abnormality in full blood count.\n* Known or suspected raised intracranial pressure, assessed by study clinician.\n* Known or suspected allergy to local anaesthetic agent or an ingredient of the anaesthetic solution.\n* History of chronic or recurrent headaches, in the opinion of the investigator.",true,"ALL","16 Years","100 Years",{"count":62,"type":63},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational cohort study is to investigate the role of immune system in neuropsychiatric symptoms (NPS) and to identify immunological biomarkers that may improve the diagnosis, prognosis, and future treatment of immune-related neuropsychiatric disorders in individuals aged 16-100 years with suspected immune-mediated neuropsychiatric symptoms and matched control participants without neuropsychiatric symptoms.\n\nThe main questions it aims to answer are what immunological mechanisms are associated with neuropsychiatric symptoms across a range of neurological, psychiatric, autoimmune, infectious, and inflammatory conditions. Also, if immunological biomarkers can be identified that may support the diagnosis, prognosis, and future treatment of neuropsychiatric disorders in which the immune system may play a role.\n\nParticipants will provide a blood sample for immunological analysis and may optionally provide a cerebrospinal fluid (CSF) sample if a suitable previously collected sample is not available. Researchers may also analyse existing clinical and biological samples where available. Participants will provide demographic and clinical information, allow access to relevant medical record data, and may optionally provide additional blood samples, up to four times within one year, for further biomarker and immunological analyses.",[67],"Neuropsychiatric Symptom",[67,69,70,71,72,73,74,75,76,77,78],"Neuroimmunology","Inflammation","Autoantibody","Autoimmune Encephalitis","Psychosis","LGI1","NMDAR","Catatonia","Lupus","Antipsychotic","NOT_YET_RECRUITING","2026-08-24",{"date":82,"type":83},"2026-08-27","ACTUAL",{"date":85,"type":63},"2026-10-01",{"date":87,"type":63},"2036-10-01",{"name":5,"class":6},2]