[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579489":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":86,"collaborators":25,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":91,"sex":96,"minAge":97,"maxAge":25,"enrollmentInfo":98,"targetDuration":25,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"Amsterdam UMC, location VUmc","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention - 5-second ventilation pause","EXPERIMENTAL","Patients in this group will have ventilation pauses lasting 5 seconds in between cardiac compressions given by mechanical CPR",[13],"Other: 5-second ventilation pause duration during mechanical CPR",{"label":15,"type":16,"description":17,"interventionNames":18},"Control - 3-second ventilation pauses","ACTIVE_COMPARATOR","Patients in this group will have ventilation pauses lasting the standard 3 seconds in between cardiac compressions given by mechanical CPR",[19],"Other: 3-second ventilation pause duration during mechanical CPR",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"5-second ventilation pause duration during mechanical CPR","The intervention is a 5-second lasting ventilation pause during mechanical CPR",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"3-second ventilation pause duration during mechanical CPR","The intervention is a 3-second lasting ventilation pause during mechanical CPR",[15],[31],{"name":32,"affiliation":33,"role":34},"Patrick Schober, MD, PhD","Amsterdam UMC","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Lotte C Doeleman, MD","CONTACT","+31205665969","l.c.doeleman@amsterdamumc.nl",{"name":42,"role":38,"phone":39,"phoneExt":25,"email":43},"Hans L van Schuppen, PhD","j.l.vanschuppen@amsterdamumc.nl",[45,68],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Ambulance Amsterdam","RECRUITING","Amsterdam","North Holland","1075LB","Netherlands","NL",{"type":54,"coordinates":55},"Point",[56,57],4.88969,52.37403,{"lat":57,"lon":56},[60,64,67],{"name":61,"role":38,"phone":62,"phoneExt":25,"email":63},"Durk S Linzel, MD","+31686897621","dlinzel@ambulanceamsterdam.nl",{"name":65,"role":38,"phone":25,"phoneExt":25,"email":66},"Ed Bleijenberg","ebleijenberg@ambulanceamsterdam.nl",{"name":61,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":69,"status":47,"city":70,"state":49,"zip":71,"country":51,"countryCode":52,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Regionale Ambulance Voorziening Kennemerland - Ambulancezorg GGD Kennemerland","Haarlem","2015CK",{"type":54,"coordinates":73},[74,75],4.63683,52.38084,{"lat":75,"lon":74},[78,82,85],{"name":79,"role":38,"phone":80,"phoneExt":25,"email":81},"Monique Theunissen","+31624920614","m.theunissen@wittekruis.nl",{"name":83,"role":38,"phone":25,"phoneExt":25,"email":84},"Anja Radstok","a.radstok@wittekruis.nl",{"name":79,"role":34,"phone":25,"phoneExt":25,"email":25},{"type":34,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Prof. Dr. Patrick Schober","Principal Investigator: Professor Emergency Medicine in Anesthesiology Dr. Patrick Schober, MD, PhD.","100579489","does-increasing-the-compression-pause-from-3-to-5-seconds-in-mechanical-compression-devices-increase-ventilation-success-rate-and-return-of-spontaneous-circulation-100579489",false,"NCT06824961","Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?","LUCASVP","Inclusion Criteria:\n\n* Adults (≥16 years of age)\n* OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel\n* LUCAS® 3.1 has been used during the resuscitation attempt\n\nExclusion Criteria:\n\n* Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses\n* Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®","ALL","16 Years",{"count":99,"type":100},692,"ESTIMATED","INTERVENTIONAL",[103],"NA","To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest compression pause after 30 compressions to facilitate caregivers in providing two ventilations. With this standard setting, research has shown that in less than half of ventilation pauses during CPR, those two ventilations are given. Increasing the ventilation pause duration to 5 seconds instead of 3 seconds is also an option following current guideline recommendations, and aligns with measured ventilation pause duration in manual CPR. Increasing pause duration to 5 seconds could result in an increased ventilation success rate. This multicenter randomized controlled trial will randomize LUCAS® mechanical compression devices to a standard setting of 3- or 5-second compression pauses. The main outcome will be the percentage of ventilation pauses in which two ventilations are successfully given. Secondary outcomes include the restoration of spontaneous circulation (ROSC), and the difference in (neurologically intact) survival. No study has been performed to evaluate this effect yet.",[106],"Cardiac Arrest (CA)",[108,109,110,111,112,113,114,115,116,117,118,119],"Advanced life support","Basic life support","Cardiac arrest","Cardiopulmonary resuscitation","CPR","ALS","BLS","Out-of-hospital cardiac arrest","OHCA","Mechanical chest compression devices","Mechanical CPR","Ventilation","2026-08-19",{"date":122,"type":123},"2026-08-21","ACTUAL",{"date":125,"type":123},"2026-01-15",{"date":127,"type":100},"2027-07",{"name":5,"class":6},2]