[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649852":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":37,"centralContacts":41,"locations":47,"responsibleParty":69,"collaborators":73,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":28,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":49,"whyStopped":28,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Shirley Ryan AbilityLab","OTHER",[8,13,18],{"label":9,"type":6,"description":10,"interventionNames":11},"Sham + AIH 15 + AIH 23","In this group, participants will undergo Sham AIH intervention first, with room oxygen, the following visit they will undergo 15, 60 second bouts of lowered oxygen, following that they will undergo 23, 60 second bouts of lowered oxygen",[12],"Other: Sham AIH",{"label":14,"type":6,"description":15,"interventionNames":16},"AIH 15 + Sham + AIH 23","In this group, participants will undergo15, 60 second bouts of lowered oxygen intervention first, the following visit they will undergo sham training with room air, following that they will undergo 23, 60 second bouts of lowered oxygen",[17],"Other: Acute Intermittent Hypoxia (AIH) 15",{"label":19,"type":6,"description":20,"interventionNames":21},"AIH 23 + AIH 15 + Sham","In this group, participants will undergo 23, 60 second bouts of lowered oxygen intervention first, the following visit they will undergo 15, 60 second bouts of lowered oxygen, following that sham training with room air, following that they will undergo",[22],"Other: Acute Intermittent Hypoxia (AIH) 23",[24,29,33],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Sham AIH","In this intervention, participants will wear a fitted mask, and will be given 15 bouts of room air through the same delivery system as the AIH interventions",[9],null,{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Acute Intermittent Hypoxia (AIH) 15","In this intervention, participants will wear a fitted mask, and will be given 15, 60 second bouts of lowered oxygen (9% O2, akin to being on a tall mountain). Following the 60 seconds of hypoxia, participants will be given 60 seconds of room air",[14],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Acute Intermittent Hypoxia (AIH) 23","In this intervention, participants will wear a fitted mask, and will be given 23, 60 second bouts of lowered oxygen (9% O2, akin to being on a tall mountain). Following the 60 seconds of hypoxia, participants will be given 60 seconds of room air",[19],[38],{"name":39,"affiliation":5,"role":40},"Milap Sandhu, PT, PhD","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":28,"email":46},"Milap Sandhu, PhD, PT","CONTACT","312-238-6529","msandhu@sralab.org",[48],{"facility":5,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Chicago","Illinois","60611","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-87.65005,41.85003,{"lat":59,"lon":58},[62,64,68],{"name":39,"role":44,"phone":63,"phoneExt":28,"email":46},"312-238-6493",{"name":65,"role":44,"phone":66,"phoneExt":28,"email":67},"Alexander Barry, MS","312-238-1435","abarry@sralab.org",{"name":39,"role":40,"phone":28,"phoneExt":28,"email":28},{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"SPONSOR_INVESTIGATOR","Milap Sandhu","Principal Investigator",[74],{"name":5,"class":6},"100649852","dose-optimization-study-of-acute-intermittent-hypoxia-in-spinal-cord-injury-100649852",false,"NCT07739992","Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury","Dose-Optimization Study of Acute Intermittent Hypoxia (DOSA-SCI): Effects on Lower-Limb Motor Function and Physiological Responsiveness in Individuals With Incomplete Spinal Cord Injury","DOSA-SCI","Inclusion Criteria:\n\n* Chronic Spinal Cord Injury (\\>6 months)\n* Motor incomplete SCI classified as AIS C or D\n* Volitional ankle plantarflexion strength in at least one leg\n\nExclusion Criteria:\n\n* Uncontrolled hypertension (outside 140\u002F90 and 90\u002F60)\n* Concurrent medical illness\n* Traumatic brain injury\n* Cardiovascular complications\n* Pulmonary complications\n* Metabolic dysfunction\n* Continued use of anti-spasticity medications\n* Previously diagnosed obstructive sleep apnea","ALL","18 Years","75 Years",{"count":87,"type":88},40,"ESTIMATED","INTERVENTIONAL",[91],"NA","This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.",[94],"Spinal Cord Injuries (SCI)",[96,97,98],"spinal cord injury","incomplete","Acute Intermittent Hypoxia","2026-07-28",{"date":101,"type":102},"2026-07-31","ACTUAL",{"date":104,"type":102},"2026-07-27",{"date":106,"type":88},"2028-07",{"name":71,"class":6},1]