[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652468":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":39,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Universitair Ziekenhuis Brussel","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Antibiotic treatment",null,[12],"Diagnostic Test: Crystalluria examination",[14],{"type":15,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"DIAGNOSTIC_TEST","Crystalluria examination",[9],[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Els Van de Perre, MD","CONTACT","0032 2 477 60 55","els.vandeperre@uzbrussel.be",[25],{"facility":5,"status":26,"city":27,"state":10,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"RECRUITING","Brussels","1090","Belgium","BE",{"type":32,"coordinates":33},"Point",[34,35],4.34878,50.85045,{"lat":35,"lon":34},[38],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100652468","drug-induced-crystalluria-in-sulfamethoxazole-high-dose-ciprofloxacin-and-high-dose-amoxicillin-100652468",false,"NCT07772752","Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin","Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin Treatment: a Prospective Study","CRYSTALLINE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Able to give informed consent without the intervention of a legal representative\n* Treatment with\n* sulfamethoxazole\u002Ftrimethoprim, with minimum dose of\n* ≥ 800\u002F160 mg q12h oral administration (PO) or intravenous administration (IV) for eGFR ≥ 30 ml\u002Fmin\n* ≥ 400\u002F80 mg q12h OR or IV for eGFR \\\u003C 30 ml\u002Fmin OR\n* high dose ciprofloxacin, defined as\n* ≥ 750 mg q12h PO or ≥ 400 mg q8h IV for eGFR ≥ 60 ml\u002Fmin\n* ≥ 750 mg q24h PO or ≥ 400 mg q12h IV for eGFR 15-59 m\u002Fmin\n* ≥ 750 mg q24h PO OR ≥ 400 mg q24h IV for eGFR \\\u003C 15 ml\u002Fmin\n\nOR\n\n* high dose amoxicillin, defined as\n* ≥ 2g q6h IV for eGFR ≥ 30 ml\u002Fmin\n* ≥ 2g q8h IV for eGFR 15-29 ml\u002Fmin\n* ≥ 2g q12h IV for eGFR \\\u003C 15 ml\u002Fmin\n* Treatment for min 24 hours and sufficiently long to perform one crystalluria investigation as defined in the protocol\n* Baseline renal function up to 72 hours prior to the start of antibiotic treatment available (evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group).\n\nExclusion Criteria:\n\n* Unable to give informed consent without the intervention of a legal representative\n* No baseline renal function up to 72 hours prior to the start of antibiotic treatment available, evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group.\n* Treatment duration \\\u003C 24 hours or insufficiently long to perform one crystalluria inves-tigation as defined in the protocol\n* Patients treated with hemodialysis or peritoneal dialysis, anuric patients before start of antibiotic treatment\n* Patients with urinary diversions","ALL","18 Years",{"count":52,"type":53},290,"ESTIMATED","INTERVENTIONAL",[56],"NA","This study examines in hospitalized patients, treated with sulfamethoxazole, high dose ciprofloxacin or high dose iv amoxicillin, the incidence of drug-induced urinary crystal formation and its association with acute kidney injury development.",[59,60,61],"Drug-induced Crystalline Nephropathy","Drug-induced Crystalluria","Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin",[63,64,65,66,67,68],"crystalluria","drug-induced acute kidney injury","drug-induced crystalline nephropathy","amoxicillin","sulfamethoxazole","ciprofloxacin","2026-08-13",{"date":71,"type":72},"2026-08-19","ACTUAL",{"date":74,"type":72},"2025-12-08",{"date":76,"type":53},"2026-12-31",{"name":5,"class":6},1]