[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650610":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":35,"centralContacts":44,"locations":50,"responsibleParty":73,"collaborators":35,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":35,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":35,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":52,"whyStopped":35,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Udayana University","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Dry Needling Group","EXPERIMENTAL","Participants receive dry needling treatment targeting active myofascial trigger points in the upper trapezius muscle according to the study protocol.",[13],"Device: Dry Needle",{"label":15,"type":10,"description":16,"interventionNames":17},"Low-Level Laser Microcurrent Electrical Stimulation (LL MCES)","Participants receive LL MCES therapy applied to the upper trapezius trigger point region according to the study protocol.",[18],"Device: Low-Level Laser Microcurrent Electrical Stimulation",{"label":20,"type":10,"description":21,"interventionNames":22},"Combined Dry Needling + LL MCES","Participants receive both dry needling and LL MCES during the same treatment session according to the study protocol.",[13,18],{"label":24,"type":25,"description":26,"interventionNames":27},"Sham Dry Needling","SHAM_COMPARATOR","Participants receive a sham dry needling procedure designed to mimic the treatment experience without therapeutic needle penetration of the trigger point.",[28],"Device: Sham Dry Needle",[30,36,40],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DEVICE","Dry Needle","Dry needling is performed using a sterile disposable filiform needle inserted into identified active trigger points of the upper trapezius muscle. The needle is manipulated to elicit a local twitch response when possible, and the procedure is conducted by a trained physician following a standardized treatment protocol.",[20,9],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"Low-Level Laser Microcurrent Electrical Stimulation","Low-Level Laser Microcurrent Electrical Stimulation (LL MCES) LL MCES is delivered using a therapeutic device that combines low-level laser irradiation and microcurrent electrical stimulation. Treatment parameters, application sites, and duration are standardized across participants.",[20,15],{"type":31,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"Sham Dry Needle","A validated sham needling technique is used in which the procedure simulates dry needling while avoiding therapeutic penetration of the myofascial trigger point. The duration and treatment setting are matched to the active dry needling intervention.",[24],[45],{"name":46,"role":47,"phone":48,"phoneExt":35,"email":49},"I Putu Eka Widyadharma, MD, PhD","CONTACT","+62 812-3787-2840","eka.widyadharma@unud.ac.id",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":35,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Denpasar","Bali","Indonesia","ID",{"type":58,"coordinates":59},"Point",[60,61],115.21667,-8.65,{"lat":61,"lon":60},[64,66,68,71],{"name":65,"role":47,"phone":48,"phoneExt":35,"email":49},"I Putu Eka Widyadharma",{"name":46,"role":67,"phone":35,"phoneExt":35,"email":35},"PRINCIPAL_INVESTIGATOR",{"name":69,"role":70,"phone":35,"phoneExt":35,"email":35},"Vincent Wijaya, MD","SUB_INVESTIGATOR",{"name":72,"role":70,"phone":35,"phoneExt":35,"email":35},"Ida Ayu Sri Wijayanti, MD, PhD",{"type":67,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"I Putu Eka Widyadharma, MD, MSc, PhD","Head of Neurology Study Program, Principal Investigator, Associate Professor","100650610","dry-needling-and-low-level-laser-microcurrent-electrical-stimulation-for-myofascial-pain-syndrome-100650610",false,"NCT07750392","Dry Needling and Low-Level Laser Microcurrent Electrical Stimulation for Myofascial Pain Syndrome","The Role of Dry Needling Therapy and Low-Level Laser Microcurrent Electrical Stimulation on Serum Levels of Tumor Necrosis Factor-alpha (TNF-α) and Malondialdehyde (MDA) in Myofascial Pain Syndrome","Inclusion Criteria:\n\n* Participants must meet all of the following criteria:\n\nAdults aged 20 to 45 years. Clinical diagnosis of acute upper trapezius myofascial pain syndrome (MPS) with symptom duration of less than 1 month.\n\nPresence of at least one active myofascial trigger point in the upper trapezius muscle confirmed by physical examination according to accepted diagnostic criteria (palpable taut band, hypersensitive trigger point, reproduction of the patient's typical pain, and\u002For local twitch response).\n\nModerate or greater neck pain (Numerical Pain Rating Scale \\[NPRS\\] ≥4). Willing and able to provide written informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Participants meeting any of the following criteria will be excluded:\n\nPrevious dry needling or LL MCES treatment for the current episode of myofascial pain.\n\nChronic myofascial pain syndrome (symptom duration ≥1 month). Current use of systemic corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other medications that may significantly influence inflammatory biomarkers within the washout period specified in the protocol.\n\nPrevious surgery, fracture, or significant trauma involving the neck or shoulder region.\n\nCervical radiculopathy, cervical myelopathy, fibromyalgia, inflammatory arthritis, or other neurological or musculoskeletal disorders that could explain the symptoms.\n\nLocal skin infection, open wound, or other contraindications to dry needling or LL MCES.\n\nBleeding disorders, anticoagulant therapy, or other contraindications to needling.\n\nPregnancy or breastfeeding. Active malignancy, autoimmune disease, uncontrolled diabetes mellitus, acute infection, or other systemic inflammatory conditions.\n\nHistory of severe psychiatric illness or inability to complete study assessments.\n\nParticipation in another interventional clinical trial within the previous 30 days.","ALL","20 Years","45 Years",{"count":87,"type":88},80,"ESTIMATED","INTERVENTIONAL",[91],"NA","This study aims to evaluate the effectiveness of dry needling and Low-Level Laser Microcurrent Electrical Stimulation (LL MCES) in patients with acute upper trapezius myofascial pain syndrome (MPS) by assessing both biological and clinical outcomes. Specifically, it investigates whether these interventions reduce serum levels of the inflammatory biomarker tumor necrosis factor-alpha (TNF-α) and the oxidative stress biomarker malondialdehyde (MDA), while also improving pain intensity and neck-related disability. The study seeks to address the current knowledge gap regarding the relationship between changes in inflammatory and oxidative stress biomarkers and clinical improvement following these non-pharmacological treatments. The primary research question is: Do dry needling and LL MCES reduce serum TNF-α and MDA levels and improve clinical outcomes in patients with acute upper trapezius myofascial pain syndrome?\n\nParticipants will:\n\nBe randomly assigned to receive dry needling, LL MCES, combined dry needling and LL MCES, or sham dry needling.\n\nReceive treatment according to the assigned intervention protocol. Undergo blood sampling before and after the intervention to measure serum TNF-α and MDA levels.\n\nComplete assessments of pain intensity using the Numerical Pain Rating Scale (NPRS) and neck-related disability using the Neck Disability Index (NDI) before and after treatment.\n\nAttend scheduled follow-up visits for clinical evaluation and outcome assessment.",[94],"Myofacial Pain Syndrome",[96,97,98,99,100],"myofascial","dry needling","laser","tnf-alpha","Malondialdehyde","2026-08-05",{"date":103,"type":104},"2026-08-10","ACTUAL",{"date":106,"type":104},"2026-07-30",{"date":108,"type":88},"2027-02-28",{"name":5,"class":6},1]