[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659219":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":48,"studyPopulation":38,"armGroups":49,"interventions":62,"overallOfficials":76,"centralContacts":84,"locations":90,"responsibleParty":117,"collaborators":120,"id":122,"slug":123,"hasResults":124,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":124,"sex":130,"minAge":131,"maxAge":132,"enrollmentInfo":133,"targetDuration":38,"studyType":136,"phases":137,"briefSummary":139,"conditions":140,"keywords":149,"overallStatus":93,"whyStopped":38,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":167},{"fullName":5,"class":6},"Al-Azhar University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":38},[9],{"measure":10,"description":11,"timeFrame":12},"Oocytes Maturation","Percentage of retrieved oocytes that are at the metaphase II (MII) stage.","From oocyte retrieval until completion of oocyte assessment, approximately 0-2 hours after retrieval.",[14,18,22,26,30,34],{"measure":15,"description":16,"timeFrame":17},"Number of MII oocytes","Number of metaphase II oocytes retrieved","At oocyte retrieval (Day 0), approximately 0-2 hours after oocyte pick up.",{"measure":19,"description":20,"timeFrame":21},"Number of oocytes retrieved","Total number of oocytes retrieved during oocyte retrieval.","Day of oocyte retrieval (Day 0) after oocyte retrieval.",{"measure":23,"description":24,"timeFrame":25},"Fertilization rate","Percentage of normally fertilized mature oocytes (2PN)","Approximately 16-18 hours after insemination\u002FICSI",{"measure":27,"description":28,"timeFrame":29},"Embryo utilization rate","Percentage of normally fertilized oocytes resulting in embryos suitable for transfer or cryopreservation","Day 3-5 after oocyte retrieval",{"measure":31,"description":32,"timeFrame":33},"Clinical pregnancy rate","Percentage of embryo transfer cycles resulting in an intrauterine gestational sac with fetal cardiac activity","Approximately 5-7 weeks after embryo transfer",{"measure":35,"description":36,"timeFrame":37},"Incidence of ovarian hyperstimulation syndrome (OHSS)","Proportion of participants developing OHSS following controlled ovarian stimulation and oocyte retrieval, classified according to predefined diagnostic\u002Fseverity criteria.","From the day of trigger administration until 14 days after oocyte retrieval",null,{"allocation":40,"interventionModel":41,"interventionModelDescription":42,"primaryPurpose":43,"observationalModel":38,"timePerspective":38,"maskingInfo":44},"RANDOMIZED","PARALLEL","Clinical Trial comparing two parallel groups receiving different ovulation triggering options during ICSI cycle","TREATMENT",{"masking":45,"maskingDescription":38,"whoMasked":46},"SINGLE",[47],"OUTCOMES_ASSESSOR","To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.\n\n* Dual Trigger Group: Participants will receive a GnRH agonist combined with hCG.\n* hCG Trigger Group: Participants will receive hCG alone.\n\nprimary Outcomes\n\nThe following primary outcomes will be assessed:\n\n• Number of mature (MII) oocytes (assessment at denudation). Secondary Outcomes\n\nThe following secondary outcomes will be assessed:\n\n* Number of retrieved oocytes.\n* Fertilization rate.\n* Number and quality of embryos.\n* Implantation rate.\n* Clinical pregnancy rate.\n* Multiple pregnancy rate.\n* Incidence of ovarian hyperstimulation syndrome (OHSS).",[50,56],{"label":51,"type":52,"description":53,"interventionNames":54},"Dual Trigger","EXPERIMENTAL","Dual Trigger Group: Participants will receive a GnRH agonist combined with hCG",[55],"Drug: Dual trigger (human chorionic gonadotropin plus GnRH-agonist)",{"label":57,"type":58,"description":59,"interventionNames":60},"HCG Trigger","ACTIVE_COMPARATOR","HCGTrigger Group: Participants will receive hCG alone.",[61],"Drug: hCG trigger",[63,70],{"type":64,"name":65,"description":66,"armGroupLabels":67,"otherNames":68},"DRUG","Dual trigger (human chorionic gonadotropin plus GnRH-agonist)","Dual Trigger Group: Participants will receive a GnRH agonist combined with hCG for normal responders patients doing ICSI.",[51],[69],"Triptorelin acetate and human chorionic gonadotropin",{"type":64,"name":71,"description":72,"armGroupLabels":73,"otherNames":74},"hCG trigger","hCG Trigger Group: Participants will receive hCG alone the standard for normal responders doing ICSI.",[57],[75],"human chorionic gonadotropin",[77,81],{"name":78,"affiliation":79,"role":80},"Ehab HM Hasanin, Professor","Obstetrics and Gynecology Department, Al-Azhar University.","STUDY_DIRECTOR",{"name":82,"affiliation":83,"role":80},"Mohamed S. Abdelall, Professor","International Islamic Center for Population Studies and Research",[85],{"name":86,"role":87,"phone":88,"phoneExt":38,"email":89},"Ahmed MM Gebreel, MSc","CONTACT","+201092576506","agebreel@hotmail.com",[91],{"facility":92,"status":93,"city":94,"state":95,"zip":38,"country":96,"countryCode":97,"cosmosGeoPoint":98,"geoPoint":103,"contacts":104},"ART Unit, International Islamic Center for Population Studies and Research, Al-Azhar University","RECRUITING","Cairo","Cairo Governorate","Egypt","EG",{"type":99,"coordinates":100},"Point",[101,102],31.24967,30.06263,{"lat":102,"lon":101},[105,109,112,115],{"name":106,"role":87,"phone":107,"phoneExt":38,"email":108},"Administration Office","+201066634172","iicpsr_azhar2@hotmail.com",{"name":110,"role":111,"phone":38,"phoneExt":38,"email":38},"Ahmed MM Gebreel, MSc.","PRINCIPAL_INVESTIGATOR",{"name":113,"role":114,"phone":38,"phoneExt":38,"email":38},"Ehab HM Hasanin, Prof.","SUB_INVESTIGATOR",{"name":116,"role":114,"phone":38,"phoneExt":38,"email":38},"Mohamed S. Abdelall, Prof.",{"type":111,"investigatorFullName":118,"investigatorTitle":119,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"Ahmed Mohamed Mohamed Gebreel","Obstetrics and Gynecology Specialist.",[121],{"name":83,"class":6},"100659219","dual-trigger-vs-hcg-trigger-for-final-oocyte-maturation-in-normal-responders-100659219",false,"NCT07861399","Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders","Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders a Randomized Controlled Trial","DT-HCG-IVF","Inclusion Criteria:\n\n* Women aged 20-40 years.\n* Body mass index (BMI) between 18 and 30 kg\u002Fm².\n* Undergoing ICSI treatment using a GnRH antagonist protocol.\n* Normal ovarian reserve and expected normal ovarian response.\n* AMH between 1.2 - 3.5 ng\u002Fml\n* AFC 7-15 follicle.\n* First or second ICSI cycle.\n\nExclusion Criteria:\n\n* Poor ovarian response (Bologna\u002FPOSEIDON criteria)\n* High ovarian response with a risk of ovarian hyperstimulation syndrome (OHSS) AMH \\> 3.5 ng\u002Fml or AFC \\> 15 follicle.\n* Polycystic ovary syndrome (PCOS).\n* Serum E2 level \\> 3500 pg\u002Fml at day of triggering.\n* Endocrine disorders including diabetes mellitus, thyroid dysfunction, hyperprolactinemia, congenital adrenal hyperplasia, or Cushing syndrome.\n* Congenital uterine abnormalities.\n* Severe systemic diseases affecting fertility outcomes.","FEMALE","20 Years","40 Years",{"count":134,"type":135},100,"ESTIMATED","INTERVENTIONAL",[138],"NA","To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.",[141,142,143,144,145,146,147,148],"ICSI","IVF","Normal Responders","Infertility Assisted Reproductive Technology","Infertile Women Undergoing IVF or ICSI","Infertile Women Undergoing ART","Triggering Ovulation","Oocyte Maturation",[150,151,152,153,154,155,156,157],"icsi","ivf","dual trigger","hcg trigger","infertility","ART","normal responders","oocyte maturation","2026-10-05",{"date":160,"type":161},"2026-10-06","ACTUAL",{"date":163,"type":161},"2026-09-01",{"date":165,"type":135},"2028-10",{"name":5,"class":6},1]