[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646607":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":39,"responsibleParty":54,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":11,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":83,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"General Hospital of Shenyang Military Region","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dyclonine Group","EXPERIMENTAL",null,[13],"Drug: Dyclonine hydrochloride mucilage",{"label":15,"type":16,"description":11,"interventionNames":17},"Tetracaine Group","ACTIVE_COMPARATOR",[18],"Drug: Tetracaine Hydrochloride Jelly",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Dyclonine hydrochloride mucilage","Dyclonine hydrochloride mucilage (10 ml: 0.1 g) will be used. Each participant will hold 10 ml of the solution in the throat for 2 minutes before swallowing, 10-15 minutes prior to gastroscopy.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Tetracaine Hydrochloride Jelly","Tetracaine hydrochloride jelly (specification: 10 g : 0.1 g) will be administered 10-15 minutes prior to gastroscopy. A nurse will spray the jelly onto the root of the participant's tongue and then instruct the participant to swallow it.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Xingshun Qi","CONTACT","18909881019","xingshunqi@126.com",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"Haoran Jia","13730977073","2976851089@qq.com",[40],{"facility":41,"status":11,"city":42,"state":43,"zip":11,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Department of Gastroenterology,General Hospital of Northern Theater Command","Shenyang","Liaoning","China","CN",{"type":47,"coordinates":48},"Point",[49,50],123.43278,41.79222,{"lat":50,"lon":49},[53],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"type":55,"investigatorFullName":31,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Director of Department of Gastroenterology","100646607","dyclonine-vs-tetracaine-for-local-anesthesia-in-unsedated-gastroscopy-100646607",false,"NCT07691346","Dyclonine vs. Tetracaine for Local Anesthesia in Unsedated Gastroscopy","Dyclonine Hydrochloride Mucilage Versus Tetracaine Hydrochloride Jelly for Local Anesthesia in Unsedated Gastroscopy: A Non-inferiority Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-75 years, of either sex;\n* Scheduled for an unsedated gastroscopy;\n* American Society of Anesthesiologists (ASA) physical status class I or II;\n* Able to understand and cooperate with Visual Analogue Scale (VAS) comfort assessment;\n* Willing to provide written informed consent voluntarily.\n\nExclusion Criteria:\n\n* Known allergy to the study agents;\n* Severe cardiopulmonary disease or hepatic\u002Frenal insufficiency;\n* Long-term use of sedatives or analgesics, or history of alcohol abuse;\n* Pregnancy or lactation;\n* Dysphagia or trismus (limited mouth opening);\n* Contraindications to upper gastrointestinal endoscopy, including acute perforation and active massive bleeding;\n* Mental or cognitive disorders that may preclude cooperation with the procedure;\n* Scheduled for therapeutic endoscopic procedures with an anticipated procedure time exceeding 15 minutes;\n* Altered upper gastrointestinal anatomy due to prior total gastrectomy, esophagectomy, or subtotal gastrectomy.","ALL","18 Years","75 Years",{"count":68,"type":69},208,"ESTIMATED","INTERVENTIONAL",[72],"NA","Gastroscopy is a key diagnostic approach for upper gastrointestinal diseases, but pharyngeal passage of the gastroscopy often causes participants' discomfort. Topical pharyngeal anesthetics are routinely used to alleviate such discomfort. Dyclonine hydrochloride mucilage and tetracaine hydrochloride jelly are the two most commonly used topical pharyngeal anesthetics in clinical practice. Although both agents are widely used, their comparative efficacy in unsedated gastroscopy remains unclear, and high-quality evidence is scarce. This study aims to compare their anesthetic efficacy,participant comfort, and safety.",[75],"Gastrointestinal Symptoms",[77,78,79,80,81,82],"Non-inferiority Trial","Dyclonine Hydrochloride","Tetracaine Hydrochloride","Visual Analogue Scale","Topical Anesthesia","Gastroscopy","NOT_YET_RECRUITING","2026-07-02",{"date":86,"type":87},"2026-07-08","ACTUAL",{"date":89,"type":69},"2026-07-01",{"date":91,"type":69},"2028-07-01",{"name":5,"class":6},1]