[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646088":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":26,"locations":32,"responsibleParty":52,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"COPD Acute exacerbation",null,"COPD patients with Severe exacerbation which is defined according to GOLD 2024 as an exacerbation requiring hospitalization or an emergency department visit, in addition to the acute worsening of respiratory symptoms occurring within ≤14 days",[13],"Diagnostic Test: Echocardiography assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Echocardiography assessment","Echocardiography assessment with focus on pulmonary artery parameters, specially Pulmonary artery systolic pressure and tricuspid valve annular Plane Systolic Excursion",[9],[21,24],{"name":22,"affiliation":5,"role":23},"Ashraf Z Mohamed, Professor","STUDY_DIRECTOR",{"name":25,"affiliation":5,"role":23},"Lamiaa H Shaaban, Professor",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Eslam M Mahran, Resident chest physician","CONTACT","+201004668567","eslammohamedelsaeed737@gmail.com",[33],{"facility":34,"status":10,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Assuit University","Asyut","Asyut Governorate","71515","Egypt","EG",{"type":41,"coordinates":42},"Point",[43,44],31.18368,27.18096,{"lat":44,"lon":43},[47,49],{"name":48,"role":29,"phone":30,"phoneExt":10,"email":31},"Eslam M Mahran, Resident Chest Physician",{"name":22,"role":29,"phone":50,"phoneExt":10,"email":51},"+201006592600","ashrafabdin@yahoo.com",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Eslam Mohamed elsaeed Mahran Ali","Resident physician in Chest diseases department","100646088","dynamic-changes-in-right-ventricle-and-pulmonary-artery-coupling-among-copd-patients-with-acute-exacerbation-100646088",false,"NCT07694713","Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation","Inclusion Criteria:\n\n* Patients aged more than 40 years diagnosed with COPD based on pulmonary function tests and admitted to ICU with severe AECOPD. Severe exacerbation is defined according to GOLD 2024 as an exacerbation requiring hospitalization or an emergency department visit, in addition to the acute worsening of respiratory symptoms occurring within ≤14 days.\n\nExclusion Criteria:\n\n* Presence of moderate to severe aortic, mitral, tricuspid, or pulmonary valvular disease\n* A known history of left-sided heart failure before enrolment\n* refusal to participate in the study","ALL","40 Years",{"count":65,"type":66},115,"ESTIMATED","OBSERVATIONAL","Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation. Acute exacerbations of COPD (AECOPD) are major events in the course of the disease and are associated with increased hospital admissions, accelerated decline in lung function, impaired quality of life, and increased mortality. Assessment of exacerbation risk remains a key component of COPD management according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD).\n\nBeyond its respiratory manifestations, COPD may have important cardiovascular consequences. Chronic hypoxia, pulmonary vascular remodeling, inflammation, and increased pulmonary vascular resistance may contribute to elevated pulmonary artery pressures and right ventricular (RV) dysfunction. Pulmonary hypertension associated with chronic lung disease is clinically important because it may worsen symptoms, exercise tolerance, and prognosis.\n\nDuring acute exacerbations, worsening hypoxemia, hypercapnia, dynamic hyperinflation, and increased respiratory workload may further increase pulmonary vascular resistance and RV afterload. Transthoracic echocardiography provides a practical non-invasive method for evaluating right ventricular function and pulmonary hemodynamics through parameters such as tricuspid annular plane systolic excursion (TAPSE), pulmonary artery systolic pressure (PASP), and the TAPSE\u002FPASP ratio, a recognized marker of RV-pulmonary artery coupling.",[70,71],"COPD Exacerbation (AECOPD)","Pulmonary Hypertension",[73,74,75],"COPD","TAPSE","PASP","NOT_YET_RECRUITING","2026-07-05",{"date":79,"type":80},"2026-07-10","ACTUAL",{"date":82,"type":66},"2026-09-01",{"date":84,"type":66},"2028-10-01",{"name":5,"class":6},1]