[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646455":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":60,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Southeast University, China","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Cardiac Surgery Patients",null,"Adult patients (18-80 years) admitted to the ICU after cardiac surgery (CABG, valve repair\u002Freplacement, major aortic surgery, or combined procedures) who meet all inclusion criteria and provide informed consent. All participants receive standard clinical care without any experimental interventions. They undergo multimodal monitoring (continuous frontal EEG, bilateral rScO₂, invasive arterial blood pressure) and serial delirium assessments (CAM-ICU) according to the study schedule.",[13],{"name":14,"affiliation":15,"role":16},"Jingyuan Xu, MD","Southeast University School of Medicine","STUDY_CHAIR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+8613851417209","xujingyuanmail@163.com",{"name":23,"role":19,"phone":24,"phoneExt":10,"email":25},"Wanting Lin, MD","13523253700","linwanting2022@126.com",[27],{"facility":28,"status":10,"city":29,"state":30,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Zhongda hospital Southeast University","Nanjing","Jiangsu","China","CN",{"type":34,"coordinates":35},"Point",[36,37],118.77778,32.06167,{"lat":37,"lon":36},[40,41],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},{"name":10,"role":19,"phone":10,"phoneExt":10,"email":21},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jingyuan,Xu","Associate Professor and Director, Department of Intensive Care Medicine","100646455","dynamic-multimodal-delirium-warning-after-cardiac-surgery-100646455",false,"NCT07686900","Dynamic Multimodal Delirium Warning After Cardiac Surgery","A Dynamic Early Warning System for Postoperative Delirium After Cardiac Surgery Integrating EEG, Cerebral Oxygenation, Hemodynamic Physiology, and Clinical Risk Factors","DEW-POD","Inclusion Criteria:\n\n1. Adult patients (18-80 years) admitted to the Department of Critical Care Medicine.\n2. Underwent cardiac surgery.\n3. Under multimodal monitoring (including EEG, cerebral oximetry, and invasive arterial blood pressure).\n4. Signed informed consent.\n\nExclusion Criteria:\n\n1. Pre-existing dementia, history of psychiatric disorders, or long-term use of antipsychotic medications, preventing accurate assessment of delirium.\n2. Preoperative severe hepatic or renal insufficiency (Child-Pugh Class C or eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²).\n3. Severe craniocerebral injury, intracranial space-occupying lesion, or history of epilepsy.\n4. Inability to obtain continuous EEG or cerebral oximetry signals due to technical reasons (e.g., scalp injury, abnormal probe placement site).\n5. Patients expected to die within 24 hours.\n6. Patients deemed unsuitable for the study by the investigator.","ALL","15 Years","80 Years",{"count":58,"type":59},200,"ESTIMATED","28 Days","OBSERVATIONAL","After heart surgery, up to half of all patients may develop a state of sudden confusion called postoperative delirium. This condition can lead to longer time on a breathing machine, extended stays in the intensive care unit (ICU), and a slower overall recovery. Currently, doctors have no reliable way to predict delirium early enough to take preventive action. This study aims to build a computer-based early warning system. The system will combine continuous, real-time measurements of brain waves (EEG), the oxygen level in the brain, and heart and blood pressure function. It will also include information about each patient's health status. By analyzing all of these signals together, the model is designed to give an alert 1 to 6 hours before delirium might start, giving the care team a window of time to intervene. The study will take place in the ICU at Zhongda Hospital, Southeast University. Adults between 18 and 80 years old who are admitted to the ICU after heart surgery will be invited to participate. All patients will receive the usual standard of care; the study does not test any new treatment. Participation means the investigators will continuously record the brain, oxygen, and heart signals that are already being monitored, and a researcher will regularly assess the patient's thinking and alertness with a simple bedside check.",[64,65],"Postoperative Delirium","Cardiac Surgical Procedures",[64,67,68,69,70,71,72,73,74],"Cardiac Surgery","Electroencephalography","EEG","Cerebral Oximetry","Near-Infrared Spectroscopy","Hemodynamics","Multimodal Monitoring","Early Warning System","NOT_YET_RECRUITING","2026-07-06",{"date":78,"type":79},"2026-07-08","ACTUAL",{"date":76,"type":59},{"date":82,"type":59},"2027-12-30",{"name":5,"class":6},1]