[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649164":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":39,"responsibleParty":59,"collaborators":37,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":37,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":37,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":37,"overallStatus":42,"whyStopped":37,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Menoufia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Caries Group","ACTIVE_COMPARATOR","About 30 participants will subject to Fluorescent Starch Nano-particles Compared with Salivary Biomarkers to detect the initial caries .",[13],"Procedure: Fluorescent Starch Nano-particles",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B: Control Group","PLACEBO_COMPARATOR","About 30 healthy participants",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Fluorescent Starch Nano-particles","The evaluation of the diagnostic accuracy of LumiCare mouth rinse combined with salivary biomarkers for the early detection of initial enamel caries and to compare its diagnostic performance with conventional clinical diagnostic methods.",[9,15],[26],"Salivary Biomarkers",[28],{"name":29,"affiliation":30,"role":31},"Walaa Mohamed Hassan, Lecturer","conservative department, Faculty of Dentistry, Menofia University","STUDY_CHAIR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Walaa Mohamed Hassan, M.D","CONTACT","+201098246330",null,"walaamohammed700@dent.menofia.edu.eg",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":37,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Menoufia Dental Hospital","RECRUITING","Shibīn al Kawm","Menoufia","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.00904,30.55258,{"lat":51,"lon":50},[54,55],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":56,"role":35,"phone":57,"phoneExt":37,"email":58},"Mahmoud Ahmed Abdo Saeed, M.D","+201226567748","dr.mahmoudsaeed2014@gmail.com",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","walaa Mohammed","Lecturer at the conservative department, Faculty of Dentistry","100649164","early-detection-of-initial-caries-using-fluorescent-starch-nano-particles-compared-with-salivary-biomarkers-100649164",false,"NCT07732127","Early Detection of Initial Caries Using Fluorescent Starch Nano-particles Compared With Salivary Biomarkers","Inclusion Criteria:\n\n\\- Presence of at least one suspected initial enamel carious lesion.\n\nExclusion Criteria:\n\n* Cavitated carious lesions\n* Previous restorative treatment on the examined tooth\n* Antibiotic therapy during the previous month,\n* Systemic diseases affecting salivary secretion\n* Xerostomia or salivary gland disorders",true,"ALL","18 Years","40 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"NA","Dental caries is one of the most prevalent chronic oral diseases worldwide and remains a major public health concern. The disease begins with microscopic demineralization of enamel, which is reversible if diagnosed at an early stage. Therefore, early detection of carious lesions is essential to implement preventive and minimally invasive treatment strategies before irreversible tooth destruction occurs.",[81],"Initial Caries","2026-08-09",{"date":84,"type":85},"2026-08-12","ACTUAL",{"date":87,"type":85},"2026-07-01",{"date":89,"type":75},"2027-07-01",{"name":5,"class":6},1]