[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100260514":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":25,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":133,"collaborators":135,"id":139,"slug":140,"hasResults":141,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":141,"sex":147,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":13,"studyType":153,"phases":13,"briefSummary":154,"conditions":155,"keywords":13,"overallStatus":115,"whyStopped":13,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Score of the predictive value of the imagery markers.","To evaluate the predictive value of imaging markers (morphological and structural connectivity imaging) for the absence of remission at 3 months in patients with PEP.","Month 3",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"CASE_ONLY","PROSPECTIVE","Recently, radiological markers demonstrated a good capacity to discriminate first episode of psychosis patients, that will show a bad response to treatment. Furthermore, automatic learning methods were recently successfully applied to neurological data, but never for the first episode psychosis patients. These powerful methods are based on multivariate analyses allowing the prediction at an individual stage. The possibility to identify more precisely the population of non-answering patients would allow the adaptation of the support in first attention for these patients, and consequently to perform appropriate cares.\n\nResearchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.","Patients suffering of schizophrenia will be included in this study. They do not have ever taken anti-psychotic treatment.",[20],{"label":21,"type":13,"description":22,"interventionNames":23},"First episode of psychosis patients","Patients with schizophrenia will be studied in this clinical trial, and that have never received anti-psychotic treatment. They will perform an MRI.",[24],"Procedure: MRI",[26],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","MRI","Magnetic Resonance Imagery will be performed on patients attempted by schizophrenia. The aim of this intervention is an early detection of the non-answering patients to the primary cares.",[21],[32],"Magnetic Resonance Imagery",[34],{"name":35,"affiliation":5,"role":36},"Eric FAKRA, MD PhD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","(0)477127885","+33","eric.fakra@chu-st-etienne.fr",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Marlène BONNEFOI, Project manager","(0)477120826","marlene.bonnefoi@chu-st-etienne.fr",[48,69,83,99,113],{"facility":49,"status":50,"city":51,"state":13,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Chu Le Vinatier","NOT_YET_RECRUITING","Bron","69500","France","FR",{"type":56,"coordinates":57},"Point",[58,59],4.91303,45.73865,{"lat":59,"lon":58},[62,65,67],{"name":63,"role":64,"phone":13,"phoneExt":13,"email":13},"Thierry DAMATO, MD","SUB_INVESTIGATOR",{"name":66,"role":64,"phone":13,"phoneExt":13,"email":13},"Frédéric HAESEBAERT, PHD",{"name":68,"role":36,"phone":13,"phoneExt":13,"email":13},"Romain REY, MD",{"facility":70,"status":50,"city":71,"state":13,"zip":72,"country":53,"countryCode":54,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Chu Clermont-Ferrand","Clermont-Ferrand","63003",{"type":56,"coordinates":74},[75,76],3.08682,45.77969,{"lat":76,"lon":75},[79,81],{"name":80,"role":64,"phone":13,"phoneExt":13,"email":13},"Isabelle CHEREAU, MD",{"name":82,"role":36,"phone":13,"phoneExt":13,"email":13},"Pierre-Michel LLORCA, MD",{"facility":84,"status":50,"city":85,"state":13,"zip":86,"country":53,"countryCode":54,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Chu Grenoble","Grenoble","38000",{"type":56,"coordinates":88},[89,90],5.71479,45.17869,{"lat":90,"lon":89},[93,95,97],{"name":94,"role":36,"phone":13,"phoneExt":13,"email":13},"Mircea POLOSAN, MD",{"name":96,"role":64,"phone":13,"phoneExt":13,"email":13},"Arnaud POUCHON, MD",{"name":98,"role":64,"phone":13,"phoneExt":13,"email":13},"Clément DONDE-COQUELET, PHD",{"facility":100,"status":50,"city":101,"state":13,"zip":102,"country":53,"countryCode":54,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"HÔPITAL Edouard Herriot","Lyon","69003",{"type":56,"coordinates":104},[105,106],4.84789,45.74906,{"lat":106,"lon":105},[109,111],{"name":110,"role":64,"phone":13,"phoneExt":13,"email":13},"Emmanuel POULET, MD",{"name":112,"role":36,"phone":13,"phoneExt":13,"email":13},"Louis SIMON, MD",{"facility":114,"status":115,"city":116,"state":13,"zip":117,"country":53,"countryCode":54,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Chu Saint Etienne","RECRUITING","Saint-Etienne","42100",{"type":56,"coordinates":119},[120,121],4.39,45.43389,{"lat":121,"lon":120},[124,125,127,129,131],{"name":35,"role":36,"phone":13,"phoneExt":13,"email":13},{"name":126,"role":64,"phone":13,"phoneExt":13,"email":13},"Maxence RIGON, MD",{"name":128,"role":36,"phone":13,"phoneExt":13,"email":13},"Maël PULCINI, MD",{"name":130,"role":64,"phone":13,"phoneExt":13,"email":13},"Colas MOREL-PRIEUR, MD",{"name":132,"role":64,"phone":13,"phoneExt":13,"email":13},"Christophe GAULD, MD",{"type":134,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR",[136],{"name":137,"class":138},"Ministry of Health, France","OTHER_GOV","100260514","early-identification-of-patients-presenting-a-first-psychotic-episode-non-answering-to-first-line-support-strategies-100260514",false,"NCT02670447","Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies","Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies: A Multicentric Study","PEPsy","Inclusion Criteria:\n\n* men and women aged 18-35 years\n* member or beneficiary of a social security scheme,\n* for women, appropriate contraception will be mandatory, as well as a negative pregnancy test,\n* patients with a diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to the DMS V\n* having never received anti-psychotic treatment,\n* followed in the hospital or outpatient,\n* having given their written informed consent,\n* that the physical examination revealed no significant clinical abnormalities\n\nExclusion Criteria:\n\n* Female patients of childbearing period without effective contraception (oral, intramuscular hormonal, intrauterine device, or surgical);\n* Patients pregnant or nursing;\n* Presenting a serious somatic or neurological disease, especially Parkinson's disease, epilepsy, debilitating tardive dyskinesia, cardiovascular disease, severe liver or kidney;\n* Featuring against-indication for an MRI; including: metallic foreign body eye or intracranial, pacemaker, heart valve, surgical clips, claustrophobia, large tattoo in the upper part of the body, not compatible with 3T MRI\n* Having a history of alcohol or drug abuse in the past year;\n* Participating in another clinical trial or being in an exclusion period of the previous protocol;\n* Patients likely to exhibit aggressive behavior self according to the judgment of the investigators.","ALL","18 Years","35 Years",{"count":151,"type":152},80,"ESTIMATED","OBSERVATIONAL","Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.",[156],"Schizophrenia","2026-09-17",{"date":159,"type":160},"2026-09-22","ACTUAL",{"date":162,"type":160},"2025-12-11",{"date":164,"type":152},"2031-04",{"name":5,"class":6},5]