[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656780":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":30,"studyPopulation":31,"armGroups":32,"interventions":26,"overallOfficials":36,"centralContacts":41,"locations":26,"responsibleParty":47,"collaborators":26,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":26,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":26,"studyType":64,"phases":26,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":26},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"Functional neurological outcome at discharge","Score on the pediatric modified Rankin Scale at hospital discharge. The scale ranges from 0 (no symptoms) to 6 (death), with higher scores indicating worse functional outcome","Up to 30 days",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"Duration of hospital stay","Length of hospital stay in days.",{"measure":18,"description":19,"timeFrame":12},"Need for intensive care unit admission","Number of children who require intensive care unit admission",{"measure":21,"description":22,"timeFrame":12},"Need for nasogastric tube feeding at discharge","Number of children who require nasogastric tube feeding at the time of hospital discharge",{"measure":24,"description":25,"timeFrame":12},"Nosocomial infections","Number of children who develop nosocomial infections during hospitalization",null,{"allocation":26,"interventionModel":26,"interventionModelDescription":26,"primaryPurpose":26,"observationalModel":28,"timePerspective":29,"maskingInfo":26},"COHORT","PROSPECTIVE","Encephalitis in children carries a high risk of neurological sequelae. This observational study will include children aged 1 month to 12 years with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.\n\nBaseline clinical, laboratory, neuroimaging, and EEG findings will be recorded. Early neurological outcome will be assessed at hospital discharge using the pediatric modified Rankin Scale (mRS).","Children aged 1 month to 12 years admitted to Assiut University Children Hospital with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.",[33],{"label":34,"type":26,"description":35,"interventionNames":26},"Single cohort: Children with encephalitis","Children aged 1 month to 12 years with possible or probable encephalitis who will be assessed for early neurological outcome at hospital discharge using the pediatric modified Rankin Scale.",[37],{"name":38,"affiliation":39,"role":40},"Faisel A Ahmed, prof","Pediatrics Department, Assiut University Hospitals","STUDY_CHAIR",[42],{"name":43,"role":44,"phone":45,"phoneExt":26,"email":46},"Rania A Hussein","CONTACT","01280633697","Rania.18313530@med.aun.edu.eg",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Rania Ahmed Hussein","Resident Physician, Pediatrics department","100656780","early-neurological-outcome-in-pediatric-encephalitis-100656780",false,"NCT07830927","Early Neurological Outcome in Pediatric Encephalitis","Predictors of Early Neurological Outcome in Children With Encephalitis: A Prospective Study From Assiut University Children Hospital","Inclusion Criteria:\n\n* Age from 1 month to 12 years\n* Possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition\n* Written informed consent from parents or legal guardians\n\nExclusion Criteria:\n\n* Pre-existing severe neurodisability pediatric modified Rankin Scale greater than or equal to 3 before the index illness\n\n  * Primary diagnosis of traumatic brain injury or cerebral malaria\n  * Known inborn error of metabolism or neurodegenerative disorder prior to the encephalitis episode\n  * Absence of documented neurologic outcome assessment","ALL","1 Month","12 Years",{"count":62,"type":63},88,"ESTIMATED","OBSERVATIONAL","This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University Children Hospital.",[67,68,69],"Encephalitis","Brain Diseases","Neurologic Manifestations",[71,72,73,74],"Pediatric encephalitis","Assiut","Modified Rankin Scale","Neurological outcome","NOT_YET_RECRUITING","2026-09-18",{"date":78,"type":79},"2026-09-22","ACTUAL",{"date":81,"type":63},"2026-09-20",{"date":83,"type":63},"2028-02-25",{"name":5,"class":6}]