[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493089":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":64,"collaborators":18,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":18,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":18,"enrollmentInfo":75,"targetDuration":18,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":18,"overallStatus":43,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1:1 Randomization to Milrinone","ACTIVE_COMPARATOR","Milrinone will be given as a bolus dose of 50 mcg\u002Fkg. If a maintenance milrinone infusion is felt to be necessary, it will be maintained at 0.125-0.375 mcg\u002Fkg\u002Fmin.",[13],"Drug: 1:1 Randomization to receive milrinone",{"label":15,"type":16,"description":17,"interventionNames":18},"1:1 No Intervention","NO_INTERVENTION","Subjects without evidence of cardiogenic shock will not receive Milrinone.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","1:1 Randomization to receive milrinone","Randomized to receive either inotropic agent: milrinone or no agent",[9],[26],"Milrinone",[28],{"name":29,"affiliation":5,"role":30},"Valluvan Jeevanandam, MD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"David Onsager, MD","CONTACT","7737021000","donsager1@uchgicagomedicine.org",{"name":38,"role":34,"phone":18,"phoneExt":18,"email":39},"Daniel Rodgers","drodgers3@uchgicagomedicine.org",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"The University of Chicago","RECRUITING","Chicago","Illinois","60637","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-87.65005,41.85003,{"lat":53,"lon":52},[56,60],{"name":57,"role":34,"phone":58,"phoneExt":18,"email":59},"Carlisa Dixon","773-834-4337","cdixon520@bsd.uchicago.edu",{"name":61,"role":34,"phone":62,"phoneExt":18,"email":63},"Leila Yazdanbakhsh","773-834-5087","leila.yazdanbakhsh@bsd.uchicago.edu",{"type":65,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100493089","early-phase-1-cardiac-power-output-in-cardiogenic-shock-patients-100493089",false,"NCT05700617","Cardiac Power Output in Cardiogenic Shock Patients","Myocardial Reserve in Advanced Heart Failure Patients","Inclusion Criteria:\n\n1. LVEF ≤ 40%\n2. Referred for RHC for:\n\n   1. Evaluation for advanced heart failure therapies, including LVAD, OHT, temporary or long-term inotrope therapy, or counter-pulsation (temporary or long-term with NuPulse device OR\n   2. Accurate assessment of invasive hemodynamics due to worsening clinical status, OR\n   3. Assessment of myocardial recovery for consideration of LVAD or counter-pulsation (temporary IABP or long-term with NuPulse device) decommissioning or removal OR\n   4. Assessment of cardiac function and valvular abnormalities prior to planned valvular surgery for MR or AI\n3. Estimated glomerular filtration rate (eGFR) ≥ 30 ml\u002Fmin\u002F1.73 m2\n4. Age ≥ 18 years-old\n5. Intent for admission based on RHC data\n\nExclusion Criteria:\n\n1. eGFR \\\u003C 30 ml\u002Fmin\u002F1.73 m2\n2. Severe, non-revascularized coronary artery disease\n3. Concurrent acute coronary syndrome\n4. Age \\\u003C 18 years-old\n5. History of significant ventricular arrhythmia without an ICD","ALL","18 Years",{"count":76,"type":77},5,"ESTIMATED","INTERVENTIONAL",[80],"EARLY_PHASE1","The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.",[83,84],"Heart Failure","Cardiogenic Shock","2026-08-04",{"date":87,"type":88},"2026-08-06","ACTUAL",{"date":90,"type":88},"2023-07-06",{"date":92,"type":77},"2027-12",{"name":5,"class":6},1]