[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651552":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":19,"responsibleParty":30,"collaborators":32,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":19,"eligibilityCriteria":41,"healthyVolunteers":38,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":19,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":59,"whyStopped":19,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":19},{"fullName":5,"class":6},"University of Virginia","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":11},"Patients with suspected ACS","EXPERIMENTAL",[12],"Diagnostic Test: Myocardial Contrast Echo (MCE) molecular imaging with Sonazoid",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Myocardial Contrast Echo (MCE) molecular imaging with Sonazoid","Subjects will undergo point-of-care MCE molecular imaging. Final adjudication of whether subjects had ACS will be made by an expert adjudication Committee",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Jonathan Lindner, MD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Jonathan R Lindner, MD","CONTACT","4342979442","jlindner@virginia.edu",{"type":23,"investigatorFullName":22,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Professor and Vice Chief for Research (CV DIvision)",[33],{"name":34,"class":35},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100651552","early-phase-1-echocardiographic-molecular-imaging-for-poc-detection-of-ischemia-100651552",false,"NCT07762495","Echocardiographic Molecular Imaging for POC Detection of Ischemia","Inclusion Criteria:\n\n* Age ≥18 years of age\n* Patients with possible or suspected ACS based on clinical criteria (history, ECG, laboratories) and HEART score \\>3.\n\nExclusion Criteria:\n\n* Cardiogenic shock\n* Inability to obtain consent\n* Severe heart failure (NYHA class IV)\n* Mechanical complication of MI (ischemic VSD, papillary muscle rupture, ventricular free wall rupture)\n* Ongoing life-threatening arrhythmias\n* Neutropenia (\\\u003C1,500\u002Fmm3)\n* Pregnancy\n* Lactation\n* Allergy to ultrasound contrast agents or eggs\n* History of autoimmune or inflammatory disease with myocardial involvement (SLE, sarcoidosis, giant cell myocarditis, etc.)","ALL","18 Years","99 Years",{"count":46,"type":47},80,"ESTIMATED","INTERVENTIONAL",[50],"EARLY_PHASE1","Molecular imaging with myocardial contrast echocardiography (MCE) relies on the non-invasive detection of targeted microbubbles (MBs) or other acoustically active agents. The confinement of MBs to the vascular compartment makes them ideal for assessing acute inflammatory responses involving endothelial cell activation and immune cell recruitment. A construct for imaging inflammation and endothelial activation can be achieved by altering amphipathic lipid shell composition in MBs. Specifically, incorporation of phosphatidylserine (PS) into the shell of MBs promotes adhesion to activated leukocytes and endothelial cells which can be used to detect ischemia, whether active or resolved. Our first in human studies to use myocardial contrast echocardiography (MCE) to detect inflammation secondary to ischemia was performed with a PS-containing MB contrast agent (Sonazoid) where we studied patients with known acute coronary syndrome (ACS) who had just undergone acute percutaneous coronary intervention. In this study, we will conduct a proof-of-concept clinical trial where MCE molecular imaging with Sonazoid will be performed in 80 patients with suspected rather than known ACS. We will test whether MCE ischemic memory imaging with MB-PS can diagnose or exclude ACS, and assess risk based on spatial extent of signal enhancement.",[53],"Acute Coronary Syndrome",[55,56,57,58],"acute coronary syndrome","echocardiography","Microbubbles","Myocardial contrast echocardiography","NOT_YET_RECRUITING","2026-08-17",{"date":62,"type":63},"2026-08-20","ACTUAL",{"date":65,"type":47},"2026-09-30",{"date":67,"type":47},"2030-07-30",{"name":5,"class":6}]