[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608958":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":24,"locations":30,"responsibleParty":48,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":11,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":11,"enrollmentInfo":62,"targetDuration":11,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":11,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Boston University Charles River Campus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"active stimulation","EXPERIMENTAL",null,[13],"Device: High definition transcranial electrical current stimulation",{"label":15,"type":16,"description":11,"interventionNames":17},"sham stimulation","SHAM_COMPARATOR",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DEVICE","High definition transcranial electrical current stimulation","Low-intensity and safe, noninvasive application of electrical current to the human scalp with the goal of gradually modulating levels of neuronal excitability.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"Robert Reinhart, PhD","CONTACT","(617) 353-9481","rmgr@bu.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"111 Cummington Mall, Boston University","RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-71.05977,42.35843,{"lat":43,"lon":42},[46],{"name":26,"role":27,"phone":47,"phoneExt":11,"email":29},"617-353-9481",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Robert Reinhart","Associate Professor","100608958","early-phase-1-restructuring-the-alpha-gamma-code-in-aging-vision-100608958",false,"NCT07208318","Restructuring the Alpha-Gamma Code in Aging Vision","Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code","Inclusion Criteria:\n\n* 18+ years of age or older\n* normal or corrected-to-normal visual acuity, color vision, and stereo vision\n\nExclusion Criteria:\n\n* not pregnant,\n* no metal implants in head,\n* no implanted electronic devices,\n* no history of neurological problems or head injury,\n* no skin sensitivity,\n* no claustrophobia,\n* no dementia (normal Mini Mental State Examination between 24-30; Montreal Cognitive Assessment \\> 25)\n* no depression (normal Beck Depression Inventory II \\\u003C13; Geriatric Depression Scale \\\u003C 10)\n* no ophthalmological diseases (e.g., strabismus, glaucoma, cataract, macular degeneration)\n* no history of psychosis\n* no cognitive deficits (MMSE score\\>24; MoCA\\>25)\n* cannot be taking any psychoactive medication.",true,"ALL","18 Years",{"count":63,"type":64},240,"ESTIMATED","INTERVENTIONAL",[67],"EARLY_PHASE1","Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred \"gamma-at-alpha-troughs\" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.",[70,71,72],"Aging","Visual Perception","Noninvasive Brain Stimulation","2026-07-14",{"date":75,"type":76},"2026-07-16","ACTUAL",{"date":78,"type":76},"2026-04-02",{"date":80,"type":64},"2030-08-31",{"name":5,"class":6},1]