[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652081":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":20,"locations":20,"responsibleParty":28,"collaborators":31,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":20,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":20,"enrollmentInfo":43,"targetDuration":20,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":53,"overallStatus":57,"whyStopped":20,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":20},{"fullName":5,"class":6},"Stanford University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: [18F]-FTC-146","EXPERIMENTAL","All participants will receive an injection of 5-10 mCi \\[18F\\]FTC-146 formulated in a sterile and pyrogen-free isotonic solution followed by PET\u002FMRI to identify sites of increased sigma-1 receptor (S1R) activity suggestive of pain generating nerve irritation or injury.\n\nEligible patients with clinical symptoms correlating to the site of abnormal uptake on \\[18F\\]FTC-146 PET\u002FMRI will then undergo cross-sectional (+\u002F- ultrasound) -guided nerve block of the S1R positive site.\n\nIf a patient notices a significant improvement in pain (≥50%), percutaneous cryoneurolysis of the S1R-positive site will then be performed within 1-4 weeks of the initial nerve block.",[13],"Drug: [18F]-FTC-146",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","[18F]-FTC-146","Participants will receive a single intravenous injection of up to 5-10 mCi of \\[18F\\] FTC-146 inside the PET\u002FMRI scanner. They will undergo up to three (3) whole-body PET\u002FMRI scans with possible additional focused scan of the painful area within 180 minutes post- injection.",[9],null,[22,26],{"name":23,"affiliation":24,"role":25},"Lynne N Martin, MD","Stanford School of Medicine, Radiology","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":24,"role":25},"Kip E Guja, MD, PhD",{"type":25,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Lynne N Martin","Clinical Assistant Professor in Radiology",[32],{"name":33,"class":6},"Society of Interventional Radiology Foundation","100652081","early-phase-1-s1r-imaging-based-cryoneurolysis-in-chronic-pain-100652081",false,"NCT07768501","S1R Imaging-Based Cryoneurolysis in Chronic Pain","Molecular Imaging-Based Cryoneurolysis: Targeting Upregulated Sigma-1 Receptor Positive Nerves in Chronic Pain","Inclusion Criteria:\n\n1. Chronic nociceptive, neuropathic, or mixed pain for ≥2 months\n2. Pain originating from a region amenable to cryoneurolysis (celiac plexus, intercostal nerves, pudendal nerve, peripheral nerve block\n3. Chronic pain ≥2 months\n4. Pain score ≥4\u002F10\n5. Pain location amenable to cryoneurolysis\n6. Willing and able to provide consent.\n\nExclusion Criteria:\n\n1. Pregnancy or nursing.\n2. Non-English speaking individuals\n3. Contraindication to MRI scanning which includes, but is not limited to, incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ.\n4. Weight \\>350 pounds or a large body habitus, which the MR scanner cannot accommodate.\n5. Claustrophobia or feeling that he or she will be unable to lie still in the scanner for a period of 2 hours or fit in the PET\u002FMR scanner due to body size.","ALL","18 Years",{"count":44,"type":45},6,"ESTIMATED","INTERVENTIONAL",[48],"EARLY_PHASE1","The goal of this clinical trial is to determine whether a sigma-1 receptor PET\u002FMRI scan can help identify the specific nerves responsible for chronic pain.\n\nResearchers will use an investigational imaging agent called \\[18F\\]FTC-146 to look for signs of pain generating nerve irritation or injury that may not be visible on convention imaging tests.\n\nParticipants whose pain-generating nerve can be identified may undergo a diagnostic nerve block and, if successful, a standard clinical procedure called cryoneurolysis will be used to temporarily interrupt pain signals.",[51,52],"Chronic Pain","Mixed Pain (Nociceptive and Neuropathic)",[54,55,56],"chronic pain","PET\u002FMRI","cryoneurolysis","NOT_YET_RECRUITING","2026-08-12",{"date":60,"type":61},"2026-08-17","ACTUAL",{"date":63,"type":45},"2026-09",{"date":65,"type":45},"2030-09",{"name":67,"class":6},"Davidzon, Guido, M.D."]