[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638402":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":16,"centralContacts":16,"locations":36,"responsibleParty":62,"collaborators":65,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":16,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":16,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":39,"whyStopped":16,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"ibuprofen","EXPERIMENTAL","Ibuprofen. a NSAID, will be ground and formed into a paste to be placed inside the root canals of necrotic mandibular posterior teeth, to explore its effects on post-operative pain",[13],"Drug: ibuprofen",{"label":15,"type":10,"description":16,"interventionNames":17},"nitrofurantoin",null,[18],"Drug: Nitrofurantoin",{"label":20,"type":21,"description":16,"interventionNames":22},"calcium hydroxide","ACTIVE_COMPARATOR",[23],"Drug: Calcium Hydroxide",[25,28,32],{"type":26,"name":9,"description":11,"armGroupLabels":27,"otherNames":16},"DRUG",[9],{"type":26,"name":29,"description":30,"armGroupLabels":31,"otherNames":16},"Nitrofurantoin","Nitrofurantoin tablets will be formed into a paste to be placed inside the root canals of necrotic mandibular premolars during endodontic treatment.",[15],{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":16},"Calcium Hydroxide","Calcium Hydroxide intracanal medicament will be placed inside the root canals of mandibular necrotic posterior teeth during endodontic treatment.",[20],[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Faculty of Oral and Dental Medicine, Egyptian Russian University","RECRUITING","Cairo","Cairo Governorate","4450113","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.24967,30.06263,{"lat":49,"lon":48},[52,57,59],{"name":53,"role":54,"phone":55,"phoneExt":16,"email":56},"Maha Nasr, Assistant professor","CONTACT","01114367063","mahmouhaa87@gmail.com",{"name":16,"role":54,"phone":16,"phoneExt":16,"email":58},"maha-nasrmorsi@eru.edu.eg",{"name":60,"role":61,"phone":16,"phoneExt":16,"email":16},"Maha Nasr, Assistant Professor","PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"Maha Nasr","Assistant Professor",[66,69],{"name":67,"class":68},"Egyptian Russian University","NETWORK",{"name":70,"class":6},"Fayoum University","100638402","early-phase-1-the-effect-of-different-intra-canal-medications-on-postoperative-pain-100638402",false,"NCT07603934","The Effect of Different Intra-canal Medications on Postoperative Pain","Evaluation of Postoperative Pain After Using Ibuprofen, Nitrofurantoin, or Calcium Hydroxide as Intracanal Medicaments in Root Canal Treatment of Necrotic Mandibular Posterior Teeth. A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients with necrotic pulps.\n2. Adult, healthy patients, older than 18 years old\n3. Males and females.\n4. Patient with the ability to understand and use pain scales.\n5. Patient who accepts enroll to the study.\n\nExclusion Criteria:\n\n1. Patients' allergies or any other contraindication to any of the medications used.\n2. Pregnant and lactating females.\n3. Patients have been taking pain medication 12 hours earlier.\n4. Patients who have more than one symptomatic mandibular tooth in the same quadrant.\n5. Patients with contributory medical history (ASA\\>II).",true,"ALL","18 Years","40 Years",{"count":83,"type":84},111,"ESTIMATED","INTERVENTIONAL",[87],"EARLY_PHASE1","The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth\n\nResearch question\u002Fhypothesis:\n\nIn patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and\u002For severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications.\n\nThe study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.",[90],"Pulp Necrosis, Apical Periodontitis",[92],"Necrotic Pulp","2026-07-20",{"date":95,"type":96},"2026-07-21","ACTUAL",{"date":98,"type":96},"2025-12-15",{"date":100,"type":84},"2027-03-15",{"name":5,"class":6},1]