[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648198":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":21,"locations":10,"responsibleParty":27,"collaborators":10,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":10,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":10,"enrollmentInfo":40,"targetDuration":10,"studyType":43,"phases":10,"briefSummary":44,"conditions":45,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":10},{"fullName":5,"class":6},"Xijing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"L-arginine",null,"Initiation of L-arginine within 3 postoperative days",[13],"Drug: L-arginine",{"label":15,"type":10,"description":16,"interventionNames":10},"No L-arginine","No L-arginine therapy within 3 postoperative days",[18],{"type":19,"name":9,"description":11,"armGroupLabels":20,"otherNames":10},"DRUG",[9],[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Zefei Zhang","CONTACT","18811797795","zzfanita7@163.com",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chong Lei, MD & phD","Principal investigator, Head of Anesthesia Clinical Research Center, Xijing Hospital","100648198","early-postoperative-l-arginine-and-acute-kidney-injury-after-cardiac-surgery-100648198",false,"NCT07718373","Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery","Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery: a Target Trial Emulation","Inclusion Criteria:\n\n·adults admitted to the ICU after CPB-assisted cardiac surgery\n\nExclusion Criteria:\n\n* congenital heart disease,\n* surgery requiring deep hypothermic circulatory arrest,\n* a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL\u002Fmin\u002F1.73 m²,\n* AKI already present prior to ICU admission","ALL","18 Years",{"count":41,"type":42},5000,"ESTIMATED","OBSERVATIONAL","Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.",[46],"Acute Kidney Injury","NOT_YET_RECRUITING","2026-08-05",{"date":50,"type":51},"2026-08-10","ACTUAL",{"date":53,"type":42},"2026-07-20",{"date":55,"type":42},"2026-08-20",{"name":5,"class":6}]