[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649466":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":35,"responsibleParty":56,"collaborators":22,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":22,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":38,"whyStopped":22,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Riphah International University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Eccentric Training","EXPERIMENTAL","Eccentric Gastrocnemius Strengthening Exercises",[13],"Other: Eccentric Gastrocnemius Strengthening Exercises",{"label":15,"type":10,"description":15,"interventionNames":16},"Low-Load Blood Flow Restriction Training",[17],"Other: Low-Load Blood Flow Restriction Training",[19,23],{"type":6,"name":11,"description":20,"armGroupLabels":21,"otherNames":22},"Eccentric Gastrocnemius Strengthening Exercises .1. Eccentric Heel Drop 2. leg press calf lowering 3. Eccentric Stair Descent (Frequency: 3 sets 10 reps in session 1-2). 1. Eccentric Heel Drop 2. leg press calf lowering 3. Eccentric Stair Descent (Frequency: 5 sets 15 reps in session 3-4). Total duration is 3 sessions per week for 4 consecutive weeks.",[9],null,{"type":6,"name":15,"description":24,"armGroupLabels":25,"otherNames":22},"Low-load blood flow restriction training including 1-Low-intensity gastrocnemius strengthening with BFR cuff 2-Controlled exercise with intermittent vascular occlusion (inflated 50-70% for 4 weeks, 3 rep. 1. Eccentric Heel Drop 2. leg press calf lowering 3. Eccentric Stair Descent (Frequency: 3 sets 10 reps in session 1-2). 1. Eccentric Heel Drop 2. leg press calf lowering 3. Eccentric Stair Descent (Frequency: 5 sets 12 reps in session 3-4).\n\nTotal duration is 3 sessions per week for 4 consecutive weeks.",[15],[27],{"name":28,"affiliation":5,"role":29},"KINZA ANWAR, MS-OMPT","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":22,"email":34},"CONTACT","+92-3239735427","kinza.anwar@riphah.edu.pk",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Railway General Hospital, Rawalpindi","RECRUITING","Rawalpindi","Punjab Province","46000","Pakistan","PK",{"type":45,"coordinates":46},"Point",[47,48],73.0479,33.59733,{"lat":48,"lon":47},[51,52,54],{"name":28,"role":32,"phone":33,"phoneExt":22,"email":34},{"name":53,"role":32,"phone":22,"phoneExt":22,"email":22},"SEHRISH MALIK, MS-OMPT*",{"name":53,"role":55,"phone":22,"phoneExt":22,"email":22},"SUB_INVESTIGATOR",{"type":57,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100649466","eccentric-vs-low-load-blood-flow-restriction-training-in-knee-osteoarthritis-in-knee-osteoarthritis-100649466",false,"NCT07733518","Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis","Comparison of Eccentric and Low-Load Blood Flow Restriction Training on Neuromuscular Adaptations in Knee Osteoarthritis","the","Inclusion Criteria:\n\n* Age group 40-70\n* Both genders male and female\n* Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee.\n* Pain stable enough to permit exercise on Numeric Pain Rating Scale 3\u002F10.\n* Participants must demonstrate a gastrocnemius muscle strength of grade ≥3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position.\n* Participants must be able to ambulate independently and participate in supervised exercise.\n\nExclusion Criteria:\n\n* • Presence of a prosthetic knee in the affected limb.\n\n  * Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA.\n  * Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension ≥160\u002F100 mmHg).\n  * Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation).\n  * History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding\u002Fclotting disorders.\n  * Current anticoagulant therapy that increases bleeding risk (unless cleared by physician).\n  * Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).","ALL","40 Years","70 Years",{"count":70,"type":71},48,"ESTIMATED","INTERVENTIONAL",[74],"NA","The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritis",[77],"Knee Arthritis, Osteoarthritis",[79,80,81,82],"Eccentric training,","Low-load blood flow restriction training","Muscle weakness","knee Osteoarthritis","2026-08-05",{"date":85,"type":86},"2026-08-07","ACTUAL",{"date":88,"type":86},"2026-07-21",{"date":90,"type":71},"2026-12-28",{"name":5,"class":6},1]