[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651520":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Xiangya Hospital of Central South University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High Inflammatory Phenotype Group",null,"Septic patients displaying serum Interleukin-6 (IL-6) ≥ 400 pg\u002FmL upon ICU admission (Day 1) .",[13],"Device: EEG monitoring",{"label":15,"type":10,"description":16,"interventionNames":17},"Low Inflammatory Phenotype Group","Septic patients displaying serum Interleukin-6 (IL-6) \\\u003C 400 pg\u002FmL upon ICU admission (Day 1) .",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DEVICE","EEG monitoring","Standard sepsis bundle treatment + 72-hour quantitative continuous EEG monitoring + structured long-term cognitive follow-up.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Lina Zhang, Dr.","CONTACT","86+15874875763","zln7095@163.com",[31],{"facility":5,"status":10,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Changsha","Hunan","410008","China","CN",{"type":38,"coordinates":39},"Point",[40,41],112.97087,28.19874,{"lat":41,"lon":40},[44],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Lina Zhang, MD, PhD","Professor and Chief of the Department of Critical Care Medicine","100651520","eeg-changes-and-cognitive-profiles-in-sepsis-patients-with-different-inflammatory-phenotypes-100651520",false,"NCT07760415","EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes","Electroencephalogram Changes and Cognitive Function Profiles in Sepsis Patients With Different Inflammatory Phenotypes","Inclusion Criteria:\n\n* Age ≥18 years and ≤90 years\n* First-time admission to the Intensive Care Unit (ICU)\n* Diagnosis of sepsis according to Sepsis-3.0 criteria (documented or clinically suspected infection plus Sequential Organ Failure Assessment \\[SOFA\\] score ≥2 points)\n* Expected ICU survival time ≥24 hours\n* Written informed consent provided by the patient or legal surrogate\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Cardiopulmonary-cerebral resuscitation (CPCR) performed during the current hospital admission\n* Pre-existing primary central nervous system (CNS) diseases, including:\n\nAcute cerebrovascular disease (e.g., hemiplegia, cranial nerve palsy) Central nervous system infection (e.g., pleocytosis in cerebrospinal fluid) Organic or metabolic encephalopathy (e.g., hepatic, renal, pulmonary, pancreatic, or severe inherited metabolic disorders) Drug-related encephalopathy (e.g., antipsychotic-associated encephalopathy, serotonin syndrome, neurotoxic antibiotics) Other structural or immunological brain diseases (e.g., traumatic brain injury, intracranial neoplasm, autoimmune encephalopathy)\n\n\\- Inability to cooperate with or tolerate scalp EEG electrode placement (e.g., extensive scalp trauma or open scalp infection)","ALL","18 Years","90 Years",{"count":60,"type":61},78,"ESTIMATED","OBSERVATIONAL","To characterize the electroencephalogram (EEG) features of sepsis patients with distinct inflammatory response phenotypes, dynamically track their evolutionary trajectories, and analyze their associations with long-term changes in cognitive function.",[65,66,67,68],"Sepsis","Sepsis Associated Encephalopathy","Sepsis and Septic Shock","Sepsis at Intensive Care Unit",[65,70,71,72,73],"Sepsis-Associated Encephalopathy","Electroencephalogram","Inflammatory Phenotype","Cognitive Dysfunction","NOT_YET_RECRUITING","2026-08-08",{"date":77,"type":78},"2026-08-12","ACTUAL",{"date":80,"type":61},"2026-08-01",{"date":82,"type":61},"2027-05-01",{"name":5,"class":6},1]