[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652176":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":71,"collaborators":30,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":30,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":97,"whyStopped":30,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Riphah International University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Bioactive glass","ACTIVE_COMPARATOR","toothpaste for white spot lesions",[13],"Other: Bioactive Glass (NovaMin)",{"label":15,"type":10,"description":16,"interventionNames":17},"Resin Infiltration(ICON)","Infiltration on the tooth surface to treat white spot lesions",[18],"Other: Resin Infiltration (ICON)",{"label":20,"type":21,"description":22,"interventionNames":23},"Fluoride toothpaste","PLACEBO_COMPARATOR","Fluoride content treats the white spot lesion",[24],"Other: Fluoride Toothpaste",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Bioactive Glass (NovaMin)","A carbonated beverage (Coca Cola, Pakistan ltd) will be used for artificial white spot lesion formation. The pH of the beverage will be 4-4.5 at 37ºC. The teeth will be immersed in demineralization solution for 4 weeks before treatment. The solution will be changed every 48 hrs. to keep the pH constant.\n\nAfter demineralization specimens will be washed with distilled deionized water (DDW). The tooth will have a white spot lesion only on the buccal surface.\n\nA sufficient amount of 5% bioactive glass (Biomin F T\u002FP) was applied on the tooth surface for three minutes using a tooth brush. The toothpaste remained on the surface for an additional 30 minutes.",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Resin Infiltration (ICON)","A carbonated beverage (Coca Cola, Pakistan ltd) was used for artificial white spot lesion formation. The pH of the beverage was 4-4.5 at 37ºC. The teeth were be immersed in demineralization solution for 4 weeks before treatment. The solution was changed every 48 hrs. to keep the pH constant.\n\nAfter demineralization specimens were washed with distilled deionized water (DDW). The tooth would have a white spot lesion only on the buccal surface.\n\nResin infiltration (ICON) infiltration will be applied according to manufacture as following:\n\n* Application of Icon Etch (15% HCL gel) for 2 minutes.\n* Water rinsing and air drying for 30 sec.\n* Application of Icon-dry (ethanol) for 30 sec.\n* Air drying\n* Application of Icon Infiltrant for 3 minutes.\n* Light curing for 40 seconds.",[15],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Fluoride Toothpaste","A carbonated beverage (Coca Cola, Pakistan ltd) was used for artificial white spot lesion formation. The pH of the beverage will be 4-4.5 at 37ºC. The teeth were immersed in demineralization solution for 4 weeks before treatment. The solution was changed every 48 hrs. to keep the pH constant.\n\nAfter demineralization specimens was washed with distilled deionized water (DDW). The tooth would have a white spot lesion only on the buccal surface.\n\nThe teeth were cleaned and dried first. 5% Sodium fluoride (Enamelist) varnish was applied on tooth surface with disposable tooth brush. The varnish remained undisturbed on teeth for 4 hours.",[20],[40],{"name":41,"affiliation":5,"role":42},"Ulfat Bashir, MDS","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Imran Amjad, PhD","CONTACT","03324390125","imran.amjad@riphah.edu.pk",[50],{"facility":51,"status":30,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Islamic International Dental Hospital","Islamabad","Capital","44000","Pakistan","PK",{"type":58,"coordinates":59},"Point",[60,61],73.04329,33.72148,{"lat":61,"lon":60},[64,66,70],{"name":41,"role":46,"phone":30,"phoneExt":30,"email":65},"ulfat.bashir@riphah.edu.pk",{"name":67,"role":46,"phone":68,"phoneExt":30,"email":69},"Ayesha Islam, MDS","+92 03332921271","ayeshaislam913@gmail.com",{"name":67,"role":42,"phone":30,"phoneExt":30,"email":30},{"type":72,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100652176","effect-of-bg-versus-ri-on-the-depth-of-wsl-100652176",false,"NCT07770724","Effect of BG Versus RI on the Depth of WSL","Effect of Bioactive Glass Versus Resin Infiltration (ICON) on the Depth of White Spot Lesions: An in Vitro Study","Inclusion Criteria:\n\n* Upper and lower premolars will be collected from patients undergoing extractions.\n\n  * The teeth should be healthy with no carious lesions.\n  * The crown and root morphology of teeth should be normal.\n  * The extracted premolar teeth of patients should have no history of previous dental treatment.\n\nExclusion Criteria:\n\n* • Fractured premolars due to any cause.\n\n  * Loss of enamel due to parafunctional habits.\n  * Presence of enamel anomalies (amelogenesis imperfecta, hypoplasia etc.).\n  * Presence of stains, demineralization, decay, fluorosis and restorations",true,"ALL","15 Years","35 Years",{"count":85,"type":86},90,"ESTIMATED","INTERVENTIONAL",[89],"NA","The aim of this in vitro study is to assess the mean lesion depth improvement and hardness of artificial white spot lesions by comparing the effects of bioactive glass toothpaste and resin infiltration (ICON).",[92],"White Spot Lesions",[94,95,96,20],"white spot lesions","orthodontic brackets","resin infiltration","NOT_YET_RECRUITING","2026-08-13",{"date":100,"type":101},"2026-08-18","ACTUAL",{"date":103,"type":86},"2026-09-01",{"date":105,"type":86},"2027-03-30",{"name":5,"class":6},1]